Patents Assigned to AAL Scientifics, Inc.
  • C-KIT-POSITIVE BONE MARROW CELLS AND USES THEREOF
    Publication number: 20230256022
    Abstract: Disclosed herein are compositions comprising myogenic bone marrow cells that are c-kit positive. Such compositions are useful for treating cardiac diseases or disorders. Also disclosed herein are methods of producing myogenic bone marrow cells are c-kit positive. Further disclosed are cardiopoietic genes having enhanced expression in c-kit positive myogenic bone marrow cells.
    Type: Application
    Filed: December 19, 2022
    Publication date: August 17, 2023
    Applicant: AAL SCIENTIFICS, INC.
    Inventors: Piero ANVERSA, Annarosa LERI
  • Pancreatic stem cells and uses thereof
    Patent number: 11534466
    Abstract: The disclosure relates to stem cells and their therapeutic use in the treatment and/or prevention of pancreatic diseases or disorders. Provided herein are compositions comprising c-kit positive pancreatic stem cells and methods of preparing and using c-kit positive pancreatic stem cells for the treatment and/or prevention of pancreatic diseases or disorders.
    Type: Grant
    Filed: March 7, 2017
    Date of Patent: December 27, 2022
    Assignee: AAL SCIENTIFICS, INC.
    Inventor: Piero Anversa
  • Treatment of heart disease
    Patent number: 10568912
    Abstract: Disclosed herein are methods, compositions and kits for treating cardiac stem cells to be administered to a subject in need thereof, e.g., with a damaged myocardium. The methods, composition and kits of the invention can be used to treat cardiovascular diseases such as heart failure, myocardial infarction and an age-related cardiomyopathy.
    Type: Grant
    Filed: November 6, 2017
    Date of Patent: February 25, 2020
    Assignee: AAL Scientifics, Inc.
    Inventors: Piero Anversa, Annarosa Leri
  • NON-MESENCHYMAL HUMAN LUNG STEM CELLS AND METHODS OF THEIR USE FOR TREATING RESPIRATORY DISEASES
    Publication number: 20200054684
    Abstract: Embodiments of the invention relate to human, non-mesenchymal c-kit positive lung stem cells negative for the CD44, CD73 and CD105 markers of the mesenchymal stromal cell lineage (non-mhLSCs) and their therapeutic use in the treatment and/or prevention of lung diseases or disorders. Provided herein are compositions comprising non-mhLSCs and methods of preparing and using non-mhLSCs for the treatment and/or prevention of lung diseases or disorders.
    Type: Application
    Filed: November 2, 2017
    Publication date: February 20, 2020
    Applicant: AAL SCIENTIFICS, INC.
    Inventors: Piero ANVERSA, Annarosa LERI
  • CARDIAC PROGENITOR CELLS HAVING ENHANCED p53 EXPRESSION AND USES THEREOF
    Publication number: 20190365822
    Abstract: Disclosed herein are compositions comprising cardiac progenitor cells that express exogenous p53 protein. Such compositions are useful for treating cardiac diseases or disorders. Also disclosed herein are methods of producing cardiac progenitor cells that express exogenous p53.
    Type: Application
    Filed: February 1, 2018
    Publication date: December 5, 2019
    Applicant: AAL SCIENTIFICS, INC.
    Inventors: Piero ANVERSA, Annarosa LERI
  • C-KIT-POSITIVE BONE MARROW CELLS AND USES THEREOF
    Publication number: 20190343888
    Abstract: Disclosed herein are compositions comprising myogenic bone marrow cells that are c-kit positive. Such compositions are useful for treating cardiac diseases or disorders. Also disclosed herein are methods of producing myogenic bone marrow cells are c-kit positive. Further disclosed are cardiopoietic genes having enhanced expression in c-kit positive myogenic bone marrow cells.
    Type: Application
    Filed: February 1, 2018
    Publication date: November 14, 2019
    Applicant: AAL SCIENTIFICS, INC.
    Inventors: Piero ANVERSA, Annarosa LERI
  • Treatment of heart disease
    Patent number: 9808489
    Abstract: Disclosed herein are methods, compositions and kits for treating cardiac stem cells to be administered to a subject in need thereof, e.g., with a damaged myocardium. The methods, composition and kits of the invention can be used to treat cardiovascular diseases such as heart failure, myocardial infarction and an age-related cardiomyopathy.
    Type: Grant
    Filed: April 22, 2016
    Date of Patent: November 7, 2017
    Assignee: AAL Scientifics, Inc.
    Inventors: Piero Anversa, Annarosa Leri
  • HUMAN LUNG STEM CELLS AND USES THEREOF
    Publication number: 20170165301
    Abstract: Embodiments of the invention relate to human stem cells and their therapeutic use in the treatment and/or prevention of lung diseases. Provided herein are compositions comprising c-kit positive human lung stem cells and methods of preparing and using c-kit positive human lung stem cells for the treatment and/or prevention of lung diseases.
    Type: Application
    Filed: November 23, 2016
    Publication date: June 15, 2017
    Applicant: AAL Scientifics, Inc.
    Inventors: Piero ANVERSA, Annarosa LERI
  • Human lung stem cells and uses thereof
    Patent number: 9534204
    Abstract: Embodiments of the invention relate to human stem cells and their therapeutic use in the treatment and/or prevention of lung diseases. Provided herein are compositions comprising c-kit positive human lung stem cells and methods of preparing and using c-kit positive human lung stem cells for the treatment and/or prevention of lung diseases.
    Type: Grant
    Filed: October 5, 2011
    Date of Patent: January 3, 2017
    Assignee: AAL Scientifics, Inc.
    Inventors: Piero Anversa, Annarosa Leri