Abstract: The present invention relates to methods for determining predisposition to a manifestation of immune system related diseases, in particular infections, associated with a mutation in the human MASP-2 gene. The invention also features oligonucleotides, polypeptides, peptide fragments and antibodies which are used in the above methods as well as for the manufacture of a medicament for treatment of a disease associated with pathological activity of the lectin-complement pathway. Moreover, the invention provides a series of gene therapy vectors and a kit for diagnosis of the disease associated with a mutation in the human MASP-2 gene.

Abstract: The present invention relates to IGF-1 treatment of an individual, such as e.g. a human being, suffering from an acute or chronic liver disease including hepatic cirrhosis. Acute and chronic liver disease according to the invention are characterized by low circulating IGF-1 and IGFBP3 levels. According to one preferred embodiment of the present invention, IGF-1 is administrered to a human being subcutaneously, preferably in the thigh or the abdominal skin, and preferably in two daily doses of about 50 microgram/kg twice a day. The present invention demonstrates that this dosis regime is able to restore normal IGF-1 levels in patients with liver cirrhosis, and the dose is well-tolerated by the patients.