Patents Assigned to Aarhus Universitet
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Patent number: 9679378Abstract: The present invention relates to a method for generating a risk map indicating predicted voxel-by-voxel probability of tissue infarction for a set of voxels, the method comprising the steps of, receiving for each voxel a first value (x) corresponding to a set of tissue marker values and generating the risk map, using a statistical model based on data from a group of subjects, and a stochastic variable, wherein the statistical model also comprises a second value (zi), being based on the stochastic variable, such as the second value modelling non-measured values. The invention may be seen as advantageous since it acknowledges subject variability in probability of tissue infarction on a voxel-by-voxel basis by taking non-measured values into account, which in turn may enable providing more reliable estimates of probability of infarction.Type: GrantFiled: September 19, 2013Date of Patent: June 13, 2017Assignee: Aarhus UniversitetInventors: Kim Mouridsen, Kartheeban Nagenthiraja, Mikkel Bo Hansen
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Patent number: 9540633Abstract: The present invention provides mutant cereal plants and mature grain thereof, characterised by enhanced levels of the enzyme phytase in the grain, and methods for inducing, detecting and selecting the mutant cereal plants. The invention further relates to animal feed comprising said grain having enhanced amounts of phytase.Type: GrantFiled: April 25, 2012Date of Patent: January 10, 2017Assignee: AARHUS UNIVERSITETInventors: Henrik Brinch-Pedersen, Claus K Madsen, Giuseppe Dionisio, Preben Bach Holm
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Patent number: 9534209Abstract: The present invention concerns 3D-crystals of complexes of ribosomal S6 kinase (RSK) and mitogen- and stress-activated protein kinase (MSK) proteins and their ligands, as well as methods for crystallization, three-dimensional structure determination and structure assisted methods for identifying ligands of said proteins.Type: GrantFiled: September 30, 2013Date of Patent: January 3, 2017Assignees: Aarhus Universitet, Region MidtjyllandInventors: Jacob Lauwring Andersen, Borbala Gesser, Poul Nissen, Lars Iversen
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Patent number: 9387232Abstract: The present invention relates to SorCS1-like agents, including SorCS1, nucleic acid molecule encoding expression of SorCS1 and fragments thereof, as well as vectors containing said nucleic acid and to cells expressing SorCS1 and said fragments, for the treatment of obesity.Type: GrantFiled: December 15, 2011Date of Patent: July 12, 2016Assignee: Aarhus UniversitetInventors: Karen-Marie Pedersen, Anders Nykjaer, Mads Fuglsang Kjolby
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Publication number: 20160189418Abstract: An image processing apparatus includes a memory configured to store a data structure in which gather rays generated by performing gather ray tracing from a rendering viewpoint are clustered hierarchically, the gather rays including a first gather ray and a second gather ray associated with the first gather ray in the data structure, and a processor configured to merge a photon gathering result associated with the second gather ray with a photon gathering result associated with the first gather ray in response to the photon gathering result associated with the first gather ray not satisfying a first condition.Type: ApplicationFiled: December 22, 2015Publication date: June 30, 2016Applicants: SAMSUNG ELECTRONICS CO., LTD., AARHUS UNIVERSITETInventors: Inwoo Ha, Minsu Ahn, Hyong Euk Lee, Jacob Toft Pedersen, Hachisuka Toshiya
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Patent number: 9314438Abstract: The present invention relates to the use of isosteviol, steviol, and related compounds for elevating the plasma HDL-cholesterol level. The invention furthermore relates to the use of these compounds for reducing the body weight of a subject and/or lowering the plasma triglyceride level of a subject, including a concomitant elevation of the plasma HDL-cholesterol level. Preferably the compounds used are isosteviol and/or steviol, or pharmaceutically acceptable salts, solvates or prodrugs thereof. The compounds may furthermore be administered in combination with one or more further active compounds, such as e.g. LDL-cholesterol lowering agents. The invention furthermore relates to a method for elevating the plasma HDL-cholesterol level in a subject by administering to a subject in need of such treatment a plasma HDL-cholesterol level elevating amount of the compounds, described herein.Type: GrantFiled: December 5, 2008Date of Patent: April 19, 2016Assignees: Aarhus Universitet, Region MidtjyllandInventors: Kjeld Hermansen, Per Bendix Jeppesen
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Publication number: 20160074424Abstract: The present invention relates to compositions comprising a steviol glycoside for use in restoring muscle glycogen by increasing the rate of glycogen re-synthesis in muscles that are depleted in glycogen due to exhaustive exercise and/or for use in treatment of muscle mass by increasing the rate of protein synthesis in muscles that are depleted in protein mass.Type: ApplicationFiled: April 22, 2014Publication date: March 17, 2016Applicant: AARHUS UNIVERSITETInventors: Per Bendix JEPPESEN, Søren LAVRSEN
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Publication number: 20150369820Abstract: The invention relates to the use of soluble CD206 as a general health/disease marker, and a specific marker for liver disorders, sepsis, and pneumonia.Type: ApplicationFiled: January 24, 2014Publication date: December 24, 2015Applicants: Aarhus Universitet, Region MidtjyllandInventors: Holger Jon Møller, Sidsel Rødgaard-Hansen
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Publication number: 20150299702Abstract: The present invention relates to inhibition of microRNAs (miRNA), other types of RNA and RNA-binding proteins. In particular the present invention relates to nucleic acid sequences that are circular and allow inhibition of the interactions between microRNAs and their RNA target and being resistant to degradation by exonucleases. Also, the present invention relates to nucleic acid sequence that are circular and acts as an RNA blocker or protein decoy.Type: ApplicationFiled: November 29, 2013Publication date: October 22, 2015Applicant: Aarhus UniversitetInventors: Peter Samuel WULFF, Mogens TERGÅRD DUCH, Shervin BAHRAMI, Jørgen KJEMS, Hansen Thomas BIRKBALLE
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Patent number: 9101117Abstract: The present invention relates to SorCS1-like agents, including SorCS1, nucleic acid molecule encoding expression of SorCS1 and fragments thereof, as well as vectors containing said nucleic acid and to cells expressing SorCS1 and said fragments, for use in the treatment of insulin resistance.Type: GrantFiled: June 10, 2010Date of Patent: August 11, 2015Assignee: Aarhus UniversitetInventors: Karen-Marie Pedersen, Anders Nykjaer
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Patent number: 9036878Abstract: The present invention relates to a method for estimating a measure of a penumbra size of a penumbra in biological tissue wherein first and second images obtained respectively by perfusion weighted imaging (PWI) and diffusion weighted imaging (DWI) are analyzed, and wherein the analysis of the first image includes application of a level set method, and the analysis of the second image includes application of a grayscale morphological operation. In a further embodiment of the invention, a connected component labeling algorithm maybe applied on any one of the first and second image. The invention further relates to a system, a computer program product and use of a corresponding method.Type: GrantFiled: December 16, 2011Date of Patent: May 19, 2015Assignees: Aarhus Universitet, Region MidtjyllandInventors: Kartheeban Nagenthiraja, Kim Mouridsen, Lars Riisgaard Ribe
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Publication number: 20150110847Abstract: A method is provided for administering an active drug agent to cells adhering and/or adjacent to a substrate, said substrate comprising one or more immobilized enzymes, which are capable of converting an inert prodrug into an active drug agent, said method comprising providing at least one inactive prodrug to said substrate. Also a kit is provided which comprise a substrate comprising one or more immobilized enzymes capable of converting an inert prodrug into an active drug agent, and at least one inert prodrug. A stent is also provided, which comprise a substrate comprising one or more immobilized enzymes capable of converting an inert prodrug into an active drug agent.Type: ApplicationFiled: May 21, 2013Publication date: April 23, 2015Applicant: Aarhus UniversitetInventors: Alexander Zelikin, Betina Fejerskov Kristensen
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Publication number: 20150050507Abstract: The present invention relates to a method of joining a metal part 1 and a non-liquid polymer part 2. The first step of the method is to attach a primer 4 to a metal surface 3 of the metal part 1. The primer 4 is then polymerized so that the metal surface 3 is at least partly covered with surface immobilized polymer brushes 5. Then the metal surface 3 with the polymer brushes 5 is brought into contact with a polymer surface of the polymer part 2, so that an interface is obtained comprising the metal surface 3, the primer 4, the polymer brushes 5 and the polymer surface. Finally, the interface is heated by use of laser welding until the polymer brushes 5 and a part of the polymer part 2 melt or soften and mix to such an extent that the metal part 1 and the polymer part 2 remain joined after cooling. The welding may e.g. be performed so that so that welding seams are obtained along equidistant lines across the surface.Type: ApplicationFiled: March 18, 2013Publication date: February 19, 2015Applicants: Aarhus Universitet, Force TechnologyInventors: Mogens Hinge, Jens Klæstrup Kristensen, Kim Daasbjerg, Steen Uttrup Pedersen, Marianne Strange, Steen-Erik Nielsen
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Publication number: 20150045284Abstract: The present invention relates to crystals of a type IB P-type ATPase having the space group P1 and methods for purification and growing said crystals. The invention also presents methods for identifying an inhibitor of a type IB P-type ATPase for example by determining binding interactions between an inhibitor and a set of binding interaction sites in said type IB P-type ATPase.Type: ApplicationFiled: January 20, 2012Publication date: February 12, 2015Applicant: Aarhus UniversitetInventors: Poul Nissen, Pontus Gourdon, Xiang Liu, Bjorn Panyella Pedersen, Daniel Mattle
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Patent number: 8945828Abstract: The present application relates to methods for identification of foetal cells and generation and isolation of binding members recognizing foetal cells. The methods of the invention may further be used for other purposes relating to characterization of biological samples and biological antigens. The methods are characterized by the applicability in situations where the interesting objects are present in a limited amount, or where the interesting objects are intermixed with other material, thus the methods are suitable for use in situations where the ratio of the interesting material compared to other material is low.Type: GrantFiled: June 27, 2011Date of Patent: February 3, 2015Assignee: Aarhus UniversitetInventors: Sten Kolvraa, Britta Christensen, Palle Schelde, Morten Draeby Sorensen, Peter Kristensen
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Publication number: 20150031739Abstract: The present invention relates to uses and methods involving Panobinostat and HIV-1. In particular relates the present invention to Panobinostat for use in the treatment of HIV-1 and especially latent HIV-1. This is done using a low dosage of Panobinostat which is highly effective in depleting the HIV-1 reservoir.Type: ApplicationFiled: January 25, 2013Publication date: January 29, 2015Applicants: Aarhus Universitet, Region MidtjyllandInventors: Martin Tolstrup, Thomas Aagaard Rasmussen, Lars Østergaard, Ole Schmeltz Søgaard, Christel Rothe Brinkmann
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Publication number: 20150017093Abstract: The present invention relates in one aspect to radiolabeled compounds comprising the structure of Formula 1. The radiolabeled compounds are preferably bile acids or bile acid derivatives. Further aspects of the invention relates to use of the compounds comprising the structure of Formula 1 in imaging methods such as for example PET, imaging method using a compound comprising the structure of Formula 1, administering said compound to an individual and making a radiographic image of a region of interest from said individual.Type: ApplicationFiled: January 29, 2013Publication date: January 15, 2015Applicants: Aarhus Universitet, Region MidtjyllandInventors: Susanne Keiding, Peter Ott, Michael Sorensen, Kim Frisch, Alan Hofmann
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Publication number: 20150004632Abstract: The present Invention relates to a diagnostic and/or prognostic method comprising measurements of proMBP-complexes (major basic protein, PRG2). In particular the Invention relates to a diagnostic and/or prognostic method comprising measurements of the concentration of two or more proMBP-complexes. Further, the Invention relates to a method for determining the redox state In a pregnant female. Additionally, the Invention relates to a reaction kit comprising detection means for detecting two or more proMBP complexes, as well as to various uses of the reaction kit. Further, the invention relates to a method of diagnosis of preeclampsia by determining the ratio between proMBP protein in complex with PAPP-A and proMBP protein in complex with angiotensinogen (ATG).Type: ApplicationFiled: October 12, 2012Publication date: January 1, 2015Applicant: AARHUS UNIVERSITETInventors: Claus Oxvig, Soren Kloverpris
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Publication number: 20140336538Abstract: The invention relates to a method for determining stretch values and movement of body parts, e.g. a foot, by analysing stretch data from a stretch sensor. By analysing data from the stretch sensor it is possible to determine stretch samples which are associated with particular motion phases. Thereby the stretch values determined from the stretch samples have a particular physical meaning since they are associated with particular motion phases.Type: ApplicationFiled: September 11, 2012Publication date: November 13, 2014Applicants: INGENIØRHØJSKOLEN AARHUS UNIVERSITET, REGION NORDJYLLAND, AALBORG SYGEHUSInventors: Ole Simonsen, Henrik Karstoft, Simon Lind Kappel, Dan Hermann, Michael Skovdal Rathleff, Peter Ahrendt
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Publication number: 20140333624Abstract: Provided is an image processing apparatus for performing photon mapping, and the image processing apparatus may perform ray tracing for photon mapping, sample a ray space based on a result of the ray tracing, and perform pseudo photon mapping using the sampled ray space.Type: ApplicationFiled: May 5, 2014Publication date: November 13, 2014Applicants: SAMSUNG ELECTRONICS CO., LTD., Aarhus UniversitetInventors: In Woo HA, Yong Beom LEE, Jacob Toft Pedersen, Toshiya Hachisuka, Do Kyoon KIM, Min Su AHN, Hyong Euk LEE