Patents Assigned to Aastrom Bioscience, Inc.
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Patent number: 8778330Abstract: The present invention relates to methods of generating an ex vivo tissue-like system in a bioreactor system capable of supporting continuous production of, and output of cells and tissues and an ex vivo tissue system made therefrom.Type: GrantFiled: March 11, 2013Date of Patent: July 15, 2014Assignee: Aastrom Biosciences, Inc.Inventors: Lee Noll, Brian Hampson, Kristin Goltry, Samantha Snabes
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Publication number: 20140193375Abstract: The present invention provides compositions of mesenchymal stromal cells which express B7-H3, their subsequent use in tissue repair, improved methods of producing tissue repair cells and method of producing a substantially pure population of CD14+ autofluorescent macrophages.Type: ApplicationFiled: May 18, 2012Publication date: July 10, 2014Applicant: AASTROM BIOSCIENCES, INC.Inventors: Frank Zeigler, Ronnda L. Bartel
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Publication number: 20140099292Abstract: The present invention provides CD 14+ cell compositions and methods of using same in treating disorders, such as inflammatory disorders, such as atherosclerosis and cardiovascular disease.Type: ApplicationFiled: September 25, 2013Publication date: April 10, 2014Applicant: Aastrom Biosciences, Inc.Inventors: Kelly Ledford, Ronnda L. Bartel, Frank Zeigler
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Publication number: 20130295057Abstract: The present invention relates to methods of generating an ex vivo tissue-like system in a bioreactor system capable of supporting continuous production of, and output of cells and tissues and an ex vivo tissue system made therefrom.Type: ApplicationFiled: March 11, 2013Publication date: November 7, 2013Applicant: AASTROM BIOSCIENCES, INC.Inventors: Lee Noll, Brian Hampson, Kristin Goltry, Samantha Snabes
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Publication number: 20130209420Abstract: The present invention provides a fluid exchange cell culture technique and tissue repair cells (TRCs) made by these methods, as well as methods using these cells. The method includes a new wash step which increases the tissue repair properties of the TRCs of the invention. This wash step allows for the production of TRC populations with greater tissue repair and anti-inflammatory capabilities. Embodiments of the present invention include a post-culture process for cultured cells that preferably includes the steps of: a wash process for removing unwanted residual culture components, a volume reduction process, and a harvesting process to remove cultured cells. Preferably, all these steps are performed within a aseptically closed cell culture chamber by implementing a separation method that minimizes mechanical disruption of the cells and is simple to automate. The harvested cells may then be concentrated to a final volume for the intended use.Type: ApplicationFiled: March 4, 2013Publication date: August 15, 2013Applicant: Aastrom Biosciences, Inc.Inventor: Aastrom Biosciences, Inc.
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Patent number: 8394631Abstract: The present invention provides a fluid exchange cell culture technique and tissue repair cells (TRCs) made by these methods, as well as methods using these cells. The method includes a new wash step which increases the tissue repair properties of the TRCs of the invention. This wash step allows for the production of TRC populations with greater tissue repair and anti-inflammatory capabilities. Embodiments of the present invention include a post-culture process for cultured cells that preferably includes the steps of: a wash process for removing unwanted residual culture components, a volume reduction process, and a harvesting process to remove cultured cells. Preferably, all these steps are performed within a aseptically closed cell culture chamber by implementing a separation method that minimizes mechanical disruption of the cells and is simple to automate. The harvested cells may then be concentrated to a final volume for the intended use.Type: GrantFiled: December 7, 2010Date of Patent: March 12, 2013Assignee: Aastrom Biosciences, Inc.Inventors: Brian Hampson, Kristin Goltry, Douglas M. Smith, Jonathan A. Rowley, Naia Venturi
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Patent number: 8394632Abstract: The present invention relates to methods of generating an ex vivo tissue-like system in a bioreactor system capable of supporting continuous production of, and output of cells and tissues and an ex vivo tissue system made therefrom.Type: GrantFiled: November 10, 2009Date of Patent: March 12, 2013Assignee: Aastrom Biosciences, Inc.Inventors: Lee Noll, Brian Hampson, Kristin Goltry, Samantha Snabes
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Publication number: 20120100108Abstract: The present invention provides methods for treating critical limb ischemia (CLI), including increasing wound healing, decreasing wound size, increasing survival-free amputation, preventing amputation, preventing or delaying de novo gangrene, increasing survival probability, and preventing or delaying death, in subjects who prevent a vascular occlusion that cannot be resolved by using a standard method of revascularization, i.e. a subject with “no-option” CLI.Type: ApplicationFiled: June 10, 2011Publication date: April 26, 2012Applicant: Aastrom Biosciences, Inc.Inventors: Ronnda Bartel, Sharon Watling
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Patent number: 8158122Abstract: The present invention provides a fluid exchange cell culture technique and tissue repair cells (TRCs) made by these methods, as well as methods using these cells. The method includes a new wash step which increases the tissue repair properties of the TRCs of the invention. This wash step allows for the production of TRC populations with greater tissue repair and anti-inflammatory capabilities. Embodiments of the present invention include a post-culture process for cultured cells that preferably includes the steps of: a wash process for removing unwanted residual culture components, a volume reduction process, and a harvesting process to remove cultured cells. Preferably, all these steps are performed within a aseptically closed cell culture chamber by implementing a separation method that minimizes mechanical disruption of the cells and is simple to automate. The harvested cells may then be concentrated to a final volume for the intended use.Type: GrantFiled: December 7, 2010Date of Patent: April 17, 2012Assignee: Aastrom Biosciences Inc.Inventors: Brian Hampson, Kristin Goltry, Douglas M. Smith, Jonathan A. Rowley, Naia Venturi
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Publication number: 20110124105Abstract: The present invention provides a fluid exchange cell culture technique and tissue repair cells (TRCs) made by these methods, as well as methods using these cells. The method includes a new wash step which increases the tissue repair properties of the TRCs of the invention. This wash step allows for the production of TRC populations with greater tissue repair and anti-inflammatory capabilities. Embodiments of the present invention include a post-culture process for cultured cells that preferably includes the steps of: a wash process for removing unwanted residual culture components, a volume reduction process, and a harvesting process to remove cultured cells. Preferably, all these steps are performed within a aseptically closed cell culture chamber by implementing a separation method that minimizes mechanical disruption of the cells and is simple to automate. The harvested cells may then be concentrated to a final volume for the intended use.Type: ApplicationFiled: December 7, 2010Publication date: May 26, 2011Applicant: Aastrom Biosciences, Inc.Inventors: Brian Hampson, Kristin Goltry, Doug Smith, Jonathan A. Rowley, Naia Venturi
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Publication number: 20110076294Abstract: The present invention provides a fluid exchange cell culture technique and tissue repair cells (TRCs) made by these methods, as well as methods using these cells. The method includes a new wash step which increases the tissue repair properties of the TRCs of the invention. This wash step allows for the production of TRC populations with greater tissue repair and anti-inflammatory capabilities. Embodiments of the present invention include a post-culture process for cultured cells that preferably includes the steps of: a wash process for removing unwanted residual culture components, a volume reduction process, and a harvesting process to remove cultured cells. Preferably, all these steps are performed within a aseptically closed cell culture chamber by implementing a separation method that minimizes mechanical disruption of the cells and is simple to automate. The harvested cells may then be concentrated to a final volume for the intended use.Type: ApplicationFiled: December 7, 2010Publication date: March 31, 2011Applicant: Aastrom Biosciences, Inc.Inventors: Brian Hampson, Kristin Goltry, Doug Smith, Jonathan A. Rowley, Naia Venturi
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Patent number: 7871605Abstract: The present invention provides a fluid exchange cell culture technique and tissue repair cells (TRCs) made by these methods, as well as methods using these cells. The method includes a new wash step which increases the tissue repair properties of the TRCs of the invention. This wash step allows for the production of TRC populations with greater tissue repair and anti -inflammatory capabilities. Embodiments of the present invention include a post-culture process for cultured cells that preferably includes the steps of: a wash process for removing unwanted residual culture components, a volume reduction process, and a harvesting process to remove cultured cells. Preferably, all these steps are performed within a aseptically closed cell culture chamber by implementing a separation method that minimizes mechanical disruption of the cells and is simple to automate. The harvested cells may then be concentrated to a final volume for the intended use.Type: GrantFiled: November 5, 2007Date of Patent: January 18, 2011Assignee: Aastrom Bioscience, Inc.Inventors: Brian Hampson, Kristin Goltry, Doug Smith, Jonathan A. Rowley, Naia Venturi
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Patent number: 7682822Abstract: The present invention relates to methods of generating an ex vivo tissue-like system in a bioreactor system capable of supporting continuous production of, and output of cells and tissues and an ex vivo tissue system made therefrom.Type: GrantFiled: March 31, 2006Date of Patent: March 23, 2010Assignee: Aastrom Biosciences, Inc.Inventors: Lee Noll, Brian Hampson, Kristin Goltry, Samantha Snabes
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Publication number: 20100055792Abstract: The present invention relates to methods of generating an ex vivo tissue-like system in a bioreactor system capable of supporting continuous production of, and output of cells and tissues and an ex vivo tissue system made therefrom.Type: ApplicationFiled: November 10, 2009Publication date: March 4, 2010Applicant: AASTROM BIOSCIENCES, INC.Inventors: Lee NOLL, Brian Hampson, Kristin Goltry, Samantha Snabes
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Publication number: 20070231305Abstract: The present invention relates to methods of generating an ex vivo tissue-like system in a bioreactor system capable of supporting continuous production of, and output of cells and tissues and an ex vivo tissue system made therefrom.Type: ApplicationFiled: March 31, 2006Publication date: October 4, 2007Applicant: AASTROM BIOSCIENCES, INC.Inventors: Lee Noll, Brian Hampson, Kristin Goltry, Samantha Snabes
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Publication number: 20060093581Abstract: A method for obtaining lineage committed human cells imbued with enhanced proliferative potential, biological function, or both, comprising culturing lineage committed human cells under physiologically acceptable liquid culture conditions, where the liquid culture medium is replaced at a rate and for a time sufficient to obtain the human lineage committed cells imbued with enhanced proliferative potential, biological function, or both; and isolating the cultured cells.Type: ApplicationFiled: December 7, 2005Publication date: May 4, 2006Applicant: AASTROM BIOSCIENCES, INC.Inventors: Alan Smith, Douglas Smith, Ramkumar Mandalam
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Patent number: 6835566Abstract: A method for obtaining lineage committed human cells imbued with enhanced proliferative potential, biological function, or both, comprising culturing lineage committed human cells under physiologically acceptable liquid culture conditions, where the liquid culture medium is replaced at a rate and for a time sufficient to obtain the human lineage committed cells imbued with enhanced proliferative potential, biological function, or both; and isolating the cultured cells.Type: GrantFiled: June 29, 2001Date of Patent: December 28, 2004Assignee: Aastrom Biosciences, Inc.Inventors: Alan K. Smith, Douglas M. Smith, Ramkumar K. Mandalam
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Publication number: 20040185557Abstract: A method for obtaining lineage committed human cells imbued with enhanced proliferative potential, biological function, or both, comprising culturing lineage committed human cells under physiologically acceptable liquid culture conditions, where the liquid culture medium is replaced at a rate and for a time sufficient to obtain the human lineage committed cells imbued with enhanced proliferative potential, biological function, or both; and isolating the cultured cells.Type: ApplicationFiled: April 2, 2004Publication date: September 23, 2004Applicant: AASTROM BIOSCIENCES, INC.Inventors: Alan K. Smith, Douglas M. Smith, Ramkumar K. Mandalam
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Publication number: 20040062755Abstract: A method for obtaining lineage committed human cells imbued with enhanced proliferative potential, biological function, or both, comprising culturing lineage committed human cells under physiologically acceptable liquid culture conditions, where the liquid culture medium is replaced at a rate and for a time sufficient to obtain the human lineage committed cells imbued with enhanced proliferative potential, biological function, or both; and isolating the cultured cells.Type: ApplicationFiled: September 24, 2003Publication date: April 1, 2004Applicant: AASTROM BIOSCIENCES, INC.Inventors: Alan K. Smith, Douglas M. Smith, Ramkumar K. Mandalam
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Publication number: 20020031498Abstract: A method for obtaining lineage committed human cells imbued with enhanced proliferative potential, biological function, or both, comprising culturing lineage committed human cells under physiologically acceptable liquid culture conditions, where the liquid culture medium is replaced at a rate and for a time sufficient to obtain the human lineage committed cells imbued with enhanced proliferative potential, biological function, or both; and isolating the cultured cells.Type: ApplicationFiled: June 29, 2001Publication date: March 14, 2002Applicant: AASTROM BIOSCIENCES, INC.Inventors: Alan K. Smith, Douglas M. Smith, Ramkumar K. Mandalam