Patents Assigned to Ab Studio Inc.
  • Heteromultimeric proteins and methods of use thereof
    Patent number: 12606622
    Abstract: The present application provides heteromultimeric proteins, such as bispecific antibodies, comprising a first antibody heavy chain constant domain 3 (CH3)-containing polypeptide having a substitution relative to a wildtype CH3 domain at amino acid position 354 with a bulky hydrophobic amino acid, and/or a second CH3-containing polypeptide comprising a substitution relative to a wildtype CH3 domain at ammo acid position 347 with a negatively charged amino acid residue. Also provided are polypeptides, nucleic acids and vectors encoding such polypeptides, pharmaceutical compositions, methods of preparation and methods of treatment using the heteromultimeric proteins.
    Type: Grant
    Filed: March 27, 2020
    Date of Patent: April 21, 2026
    Assignee: AB Studio Inc.
    Inventors: Yue Liu, Jianbo Dong, Bo Wang
  • Catabodies and methods of use thereof
    Patent number: 12372534
    Abstract: The present application provides methods, compositions and kits for determining SHD catabody levels in a biological sample, and for treating or preventing a protein aggregation disease (PAD) in an individual. Also provided are catabodies specifically recognizing amyloid beta (A?) peptides and methods of use thereof.
    Type: Grant
    Filed: October 7, 2022
    Date of Patent: July 29, 2025
    Assignee: AB Studio Inc.
    Inventor: Yue Liu
  • Catabodies and methods of use thereof
    Patent number: 12259395
    Abstract: The present application provides methods, compositions and kits for determining SHD catabody levels in a biological sample, and for treating or preventing a protein aggregation disease (PAD) in an individual. Also provided are catabodies specifically recognizing amyloid beta (A?) peptides and methods of use thereof.
    Type: Grant
    Filed: August 16, 2019
    Date of Patent: March 25, 2025
    Assignee: AB Studio Inc.
    Inventor: Yue Liu
  • Bispecific antibodies and uses thereof
    Patent number: 12049517
    Abstract: This disclosure relates to bispecific antibodies or antigen-binding fragments thereof, wherein the bispecific antibodies or antigen-binding fragments thereof specifically bind to two different antigens with different binding affinities.
    Type: Grant
    Filed: August 1, 2018
    Date of Patent: July 30, 2024
    Assignee: Ab Studio Inc.
    Inventors: Yue Liu, Wenyan Cai, Jiadong Shi
  • Bispecific antibodies and uses thereof
    Patent number: 11566083
    Abstract: This disclosure relates to bispecific antibodies or antigen-binding fragments thereof, wherein the bispecific antibodies or antigen-binding fragments thereof specifically bind to two different antigens with different binding affinities.
    Type: Grant
    Filed: August 10, 2021
    Date of Patent: January 31, 2023
    Assignee: Ab Studio Inc.
    Inventors: Yue Liu, Wenyan Cai, Jiadong Shi
  • Bispecific antibodies and uses thereof
    Patent number: 11440972
    Abstract: This disclosure relates to bispecific antibodies or antigen-binding fragments thereof, wherein the bispecific antibodies or antigen-binding fragments thereof specifically bind to two different antigens with different binding affinities.
    Type: Grant
    Filed: August 10, 2021
    Date of Patent: September 13, 2022
    Assignee: Ab Studio Inc.
    Inventors: Yue Liu, Wenyan Cai, Jiadong Shi