Patents Assigned to ABALOS THERAPEUTICS GMBH
  • Method of enhancing innate immune responses against a tumor comprising administering lymphocytic choriomeningitis virus (LCMV)
    Patent number: 11801294
    Abstract: The invention relates to arenaviruses for use in the treatment and/or prevention of tumors and also a method for preparing arenaviruses with (improved) tumor-regressive properties.
    Type: Grant
    Filed: February 4, 2019
    Date of Patent: October 31, 2023
    Assignee: ABALOS THERAPEUTICS GMBH
    Inventors: Karl Sebastian Lang, Halime Kalkavan
  • NEW VIRUS PARTICLES FOR THERAPEUTIC PURPOSES
    Publication number: 20220273741
    Abstract: The invention relates to a virus particle comprising a lymphocytic choriomeningitis virus (LCMV) S segment and an LCMV L segment, wherein the S segment comprises an open reading frame encoding a glycoprotein derived from LCMV strain WE, and wherein the L segment comprises an open reading frame encoding an L protein derived from LCMV strain Clone13. The invention also relates to related host cells, methods of producing such virus particles, pharmaceutical compositions comprising such virus particles, and medical uses of such virus particles.
    Type: Application
    Filed: February 25, 2022
    Publication date: September 1, 2022
    Applicant: Abalos Therapeutics GmbH
    Inventors: Jorg VOLLMER, Marcus KOSTKA, Philipp LANG, Haifeng XU
  • METHOD FOR PRODUCING AN ANTITUMORAL ARENAVIRUS AS WELL AS ARENAVIRUS MUTANTS
    Publication number: 20220033445
    Abstract: The invention relates to a mutant of an arenavirus having improved antitumoral properties. The invention also relates to a method of generating such an arenavirus mutant, related pharmaceutical compositions, medical uses, methods of treatment, and isolated proteins and nucleic acids.
    Type: Application
    Filed: September 12, 2019
    Publication date: February 3, 2022
    Applicant: ABALOS THERAPEUTICS GMBH
    Inventors: Karl LANG, Cornelia HARDT, Michael BERGERHAUSEN, Hilal BHAT