Patents Assigned to Abaxis, Inc.
  • Patent number: 10921321
    Abstract: The invention provides compositions (e.g., peptide compositions) useful for the detection of antibodies that bind to Borrelia antigens. The peptide compositions comprise polypeptide sequences comprising variants in the IR6 domain of the Borrelia VlsE protein. The invention also provides devices, methods, and kits comprising such peptide compositions and useful for the detection of antibodies that bind to Borrelia antigens and the diagnosis of Lyme disease.
    Type: Grant
    Filed: September 10, 2018
    Date of Patent: February 16, 2021
    Assignee: Abaxis, Inc.
    Inventors: Rajesh K. Mehra, Kenneth P. Aron, Dennis M. Bleile, Jeremy Walker, Cristina Cuesico
  • Patent number: 10488409
    Abstract: The present invention relates to analyte detection devices and methods of using such devices to detect minute quantities of a target analyte in a sample. In particular, the invention provides an analyte detection device comprising a plurality of composite metallic nanostructures conjugated to analyte binding partners and a surface containing a metallic nanolayer on which a plurality of capture molecules is immobilized. Methods of preparing composite nanostructures are also described.
    Type: Grant
    Filed: August 13, 2015
    Date of Patent: November 26, 2019
    Assignee: Abaxis, Inc.
    Inventors: Rajesh K. Mehra, Vincent Chiang, Kenneth P. Aron, Asher Krell
  • Patent number: 10444231
    Abstract: The invention provides peptide compositions and mixtures useful for the detection of antibodies that bind to Ehrlichia antigens. The peptide compositions and mixtures comprise polypeptide sequences based on an immunogenic fragment of the Ehrlichia Outer Membrane Protein 1 (OMP-1) protein. The invention also provides devices, methods, and kits comprising such peptide compositions and mixtures useful for the detection of antibodies that bind to Ehrlichia antigens and the diagnosis of monocytic and/or granulocytic ehrlichiosis.
    Type: Grant
    Filed: May 30, 2017
    Date of Patent: October 15, 2019
    Assignee: Abaxis, Inc.
    Inventors: Rajesh K. Mehra, Kenneth P. Aron, Dennis M. Bleile, Timothy P. Forsyth, Jeremy D. Walker, Cristina R. Cuesico
  • Patent number: 10429383
    Abstract: The present invention relates to analyte detection devices and methods of using such devices to detect minute quantities of a target analyte in a sample. In particular, the invention provides a method of detecting a target analyte in a sample comprising mixing the sample with a first detection conjugate and a second detection conjugate in solution, wherein the first and second detection conjugates comprise metallic nanostructures coupled to binding partners that are capable of specifically binding to the target analyte if present in the sample to form a complex between the first detection conjugate, the analyte, and the second detection conjugate, wherein a change in an optical signal upon complex formation indicates the presence of the target analyte in the sample. Methods of preparing nanostructures and nanoalloys, as well as nanostructures and nanoalloys conjugated to binding partners, are also described.
    Type: Grant
    Filed: October 31, 2017
    Date of Patent: October 1, 2019
    Assignee: Abaxis, Inc.
    Inventors: Rajesh Mehra, Vincent Chiang, Kenneth Aron, Jessica Frisz
  • Patent number: 10371701
    Abstract: The present invention provides an analyte detection system for detecting target analytes in a sample. In particular, the invention provides a detection system in a rotor or disc format that utilizes a centrifugal force to move the sample through the detection system. Methods of using the rotor detection system to detect analytes in samples, particularly biological samples, and kits comprising the rotor detection system are also disclosed.
    Type: Grant
    Filed: October 13, 2017
    Date of Patent: August 6, 2019
    Assignee: abaxis, inc.
    Inventors: Rajesh K. Mehra, Kenneth P. Aron
  • Patent number: 10073095
    Abstract: The invention provides compositions (e.g., peptide compositions) useful for the detection of antibodies that bind to Borrelia antigens. The peptide compositions comprise polypeptide sequences comprising variants in the IR6 domain of the Borrelia VlsE protein. The invention also provides devices, methods, and kits comprising such peptide compositions and useful for the detection of antibodies that bind to Borrelia antigens and the diagnosis of Lyme disease.
    Type: Grant
    Filed: August 23, 2017
    Date of Patent: September 11, 2018
    Assignee: Abaxis, Inc.
    Inventors: Rajesh K. Mehra, Kenneth P. Aron, Dennis M. Bleile, Jeremy Walker, Cristina Cuesico
  • Patent number: 8846319
    Abstract: The present invention discloses analyte detection devices for detecting one or more analytes present in test samples, especially biological samples. In particular, the devices of the invention are lateral flow assay devices comprising immobilized metal nanoparticle conjugates as the detection means. Methods of using the devices and kits comprising the devices are also described.
    Type: Grant
    Filed: December 3, 2009
    Date of Patent: September 30, 2014
    Assignee: Abaxis, Inc.
    Inventors: Rajesh K. Mehra, Kenneth P. Aron
  • Patent number: 8828675
    Abstract: The invention provides compositions (e.g., peptide compositions) useful for the detection of antibodies that bind to Ehrlichia antigens. The peptide compositions comprise polypeptide sequences based on an immunogenic fragment of the Ehrlichia Outer Membrane Protein 1 (OMP-1) protein. The invention also provides devices, methods, and kits comprising such peptide compositions and useful for the detection of antibodies that bind to Ehrlichia antigens and the diagnosis of monocytic ehrlichiosis.
    Type: Grant
    Filed: November 19, 2010
    Date of Patent: September 9, 2014
    Assignee: Abaxis, Inc.
    Inventors: Rajesh K. Mehra, Kenneth P. Aron, Dennis M. Bleile
  • Patent number: 8758772
    Abstract: The invention provides compositions (e.g., peptide compositions) useful for the detection of antibodies that bind to Borrelia antigens. The peptide compositions comprise polypeptide sequences comprising variants in the IR6 domain of the Borrelia VlsE protein. The invention also provides devices, methods, and kits comprising such peptide compositions and useful for the detection of antibodies that bind to Borrelia antigens and the diagnosis of Lyme disease.
    Type: Grant
    Filed: November 2, 2012
    Date of Patent: June 24, 2014
    Assignee: Abaxis, Inc.
    Inventors: Rajesh K. Mehra, Kenneth P. Aron, Dennis M. Bleile, Jeremy Walker, Cristina Cuesico
  • Patent number: 8673576
    Abstract: The present invention discloses methods for detecting the presence of a complex between a first reagent and a second reagent in solution. In particular, the invention provides methods for qualitative or quantitative detection of an analyte or its specific binding partner in complex biological samples. The invention further discloses algorithms using summary rate changes at selected wavelengths in the absorbance spectra of colloidal metal-labeled analytes or specific binding partners to identify intermolecular interactions between the analyte and its binding partner.
    Type: Grant
    Filed: March 19, 2012
    Date of Patent: March 18, 2014
    Assignee: Abaxis, Inc.
    Inventors: Vincent Chiang, Rajesh K. Mehra
  • Patent number: 8568989
    Abstract: The invention provides compositions (e.g., peptide compositions) useful for the detection of antibodies that bind to Borrelia antigens. The peptide compositions comprise polypeptide sequences comprising variants in the IR6 domain of the Borrelia VlsE protein. The invention also provides devices, methods, and kits comprising such peptide compositions and useful for the detection of antibodies that bind to Borrelia antigens and the diagnosis of Lyme disease.
    Type: Grant
    Filed: November 17, 2010
    Date of Patent: October 29, 2013
    Assignee: Abaxis, Inc.
    Inventors: Rajesh K. Mehra, Kenneth P. Aron, Dennis M. Bleile
  • Patent number: 8530152
    Abstract: The present invention discloses methods of reducing non-specific interactions of interfering species present in a sample in metallic nanoparticle-based assays, thereby increasing the sensitivity of these assays. In particular, the methods entail neutralizing the chemical reactivity of functional groups present in interfering species by addition of a neutralizing agent, such as an alkylating agent or heavy metal ion. The methods are especially useful in assays for the detection of analytes in biological samples. Reagent kits and assay mixtures for the practice of the described methods are also disclosed.
    Type: Grant
    Filed: July 9, 2009
    Date of Patent: September 10, 2013
    Assignee: Abaxis, Inc.
    Inventors: Rajesh K. Mehra, Vincent Chiang, Kenneth Aron
  • Patent number: 8377643
    Abstract: The present invention provides an analyte detection system for detecting a target analyte in a sample. In particular, the invention provides a detection system capable of one-step amplification of the detection signal by incorporating a secondary flow path that can deliver reagents to a reaction zone. Methods of using the detection system to detect analytes in samples, particularly biological samples, and kits comprising the detection system are also disclosed.
    Type: Grant
    Filed: March 11, 2010
    Date of Patent: February 19, 2013
    Assignee: Abaxis, Inc.
    Inventors: Rajesh Mehra, Kenneth P. Aron, Madeline Netto
  • Publication number: 20120252005
    Abstract: The present invention discloses methods for detecting the presence of a complex between a first reagent and a second reagent in solution. In particular, the invention provides methods for qualitative or quantitative detection of an analyte or its specific binding partner in complex biological samples. The invention further discloses algorithms using summary rate changes at selected wavelengths in the absorbance spectra of colloidal metal-labeled analytes or specific binding partners to identify intermolecular interactions between the analyte and its binding partner.
    Type: Application
    Filed: March 19, 2012
    Publication date: October 4, 2012
    Applicant: Abaxis, Inc.
    Inventors: Vincent CHIANG, Rajesh K. Mehra
  • Patent number: 8137920
    Abstract: The present invention discloses methods for detecting the presence of a complex between a first reagent and a second reagent in solution. In particular, the invention provides methods for qualitative or quantitative detection of an analyte or its specific binding partner in complex biological samples. The invention further discloses algorithms using summary rate changes at selected wavelengths in the absorbance spectra of colloidal metal-labeled analytes or specific binding partners to identify intermolecular interactions between the analyte and its binding partner.
    Type: Grant
    Filed: March 18, 2009
    Date of Patent: March 20, 2012
    Assignee: Abaxis, Inc.
    Inventors: Vincent Chiang, Rajesh K. Mehra
  • Publication number: 20110276342
    Abstract: Methods for determining the validity or accuracy of a clinical test result are provided. The methods entail obtaining patient analyte concentration data for two or more analytes with a concentration relationship; calculating a likelihood distribution for the concentration relationship between the two or more analytes; obtaining a clinical test result comprising measured concentration values for the two or more analytes; and determining the validity or accuracy of the clinical test result based on whether the clinical test result falls within the boundaries of the likelihood distribution. Analyte pairs that can be analyzed by the methods of the invention include albumin/calcium, sodium/chloride, BUN/creatinine, AST/ALT, total protein/albumin, potassium/total CO2, calcium/phosphorus, calcium/magnesium, potassium/creatinine, magnesium/potassium, Anion gap/potassium, sodium/potassium, chloride/potassium, magnesium/phosphate, ALT/GGT, ALT/ALP, CK/LDH and chloride/total CO2.
    Type: Application
    Filed: May 6, 2011
    Publication date: November 10, 2011
    Applicant: Abaxis, Inc.
    Inventor: Steven C. KAZMIERCZAK
  • Publication number: 20110151435
    Abstract: The present invention provides methods of detecting analytes using particles having different physico-chemical properties, such as buoyancy, size, density, spectral characteristics, and/or binding properties, in solution-based sandwich assays and solution-based competition assays. The methods can be performed using rotors and bench-top centrifuges and provide for rapid, qualitative and quantitative detection of analytes. The present invention also provides kits that can be used to perform the methods, and mixtures containing particles suitable for the methods.
    Type: Application
    Filed: December 17, 2010
    Publication date: June 23, 2011
    Applicant: Abaxis, Inc.
    Inventors: Rajesh K. MEHRA, Kenneth P. ARON
  • Publication number: 20110124125
    Abstract: The invention provides compositions (e.g., peptide compositions) useful for the detection of antibodies that bind to Ehrlichia antigens. The peptide compositions comprise polypeptide sequences based on an immunogenic fragment of the Ehrlichia Outer Membrane Protein 1 (OMP-1) protein. The invention also provides devices, methods, and kits comprising such peptide compositions and useful for the detection of antibodies that bind to Ehrlichia antigens and the diagnosis of monocytic ehrlichiosis.
    Type: Application
    Filed: November 19, 2010
    Publication date: May 26, 2011
    Applicant: Abaxis, Inc.
    Inventors: Rajesh K. MEHRA, Kenneth P. ARON, Dennis M. BLEILE
  • Publication number: 20100233708
    Abstract: The present invention provides an analyte detection system for detecting a target analyte in a sample. In particular, the invention provides a detection system capable of one-step amplification of the detection signal by incorporating a secondary flow path that can deliver reagents to a reaction zone. Methods of using the detection system to detect analytes in samples, particularly biological samples, and kits comprising the detection system are also disclosed.
    Type: Application
    Filed: March 11, 2010
    Publication date: September 16, 2010
    Applicant: Abaxis, Inc.
    Inventors: Rajesh MEHRA, Kenneth P. Aron, Madeline Netto
  • Patent number: 7765069
    Abstract: Methods and systems are provided for detecting the accidental use of short and long samples in the clinical analysis of a sample, specimen, or assay. The systems can include a clinical analyzer for determining one or more values for one or more measurable characteristics of a sample. These values are used in combination with reference data stored in a data module to generate a probability that the sample tested is a short sample, a long sample, or an acceptable sample. This probability and/or the status of the sample as a short sample, a long sample, or an acceptable sample are output to a user.
    Type: Grant
    Filed: August 4, 2005
    Date of Patent: July 27, 2010
    Assignee: Abaxis, Inc.
    Inventors: Vladimir E. Ostoich, Kenneth Aron, Dennis M. Bleile