Abstract: N-(2-((4-Hydroxyphenyl)amino)pyridin-3-yl)-4-methoxybenzenesulfonamide Crystalline Form 1, ways to make it, compositions containing it and methods of treatment of diseases using it are disclosed.
Type:
Grant
Filed:
January 13, 2006
Date of Patent:
November 11, 2008
Assignee:
Abbott Laboratories Inc.
Inventors:
Eric A. Schmitt, Ira S. Buckner, Geoff G. Z. Zhang, Rodger F. Henry
Abstract: The present invention relates to a stable liquid calibrator or control for use in ligand-binding assays wherein the calibrator or control comprises at least one human synthetic natriuretic peptide and has a pH of from about 4.0 to about 6.5 and remains stable when stored at temperatures of from about 2 to about 8°C. for a period of about twelve months.
Type:
Grant
Filed:
July 16, 2003
Date of Patent:
November 4, 2008
Assignee:
Abbott Laboratories, Inc.
Inventors:
Judith A. Friese, Matthew S. Matias, Ray A. Weigand
Abstract: N-((2Z)-2-((4-Hydroxyphenyl)imino)-1,2-dihydro-3-pyridinyl)-4-methoxybenzenesulfonamide Crystalline Form 2, ways to make it, compositions containing it and methods of treatment of diseases using it are disclosed.
Type:
Grant
Filed:
January 13, 2006
Date of Patent:
November 4, 2008
Assignee:
Abbott Laboratories Inc.
Inventors:
Eric A. Schmitt, Ira S. Buckner, Geoff G. Z. Zhang, Rodger F. Henry
Abstract: Parenteral formulations of peptides which are useful for sustained release are disclosed. Also disclosed are methods of preparation for the formulations.
Type:
Grant
Filed:
June 6, 2003
Date of Patent:
October 7, 2008
Assignee:
Abbott Laboratories Inc.
Inventors:
Fortuna Haviv, Bryan K. Erickson, Jack Henkin, Luk C. Li, Fanfeng Ma, Friedrich W. Richter, Yi Shi, Jingfeng Song, Siriporn Toongsuwan
Abstract: The present invention relates to compounds of formula (I-VII) or a pharmaceutically acceptable salt or prodrug thereof, in which A, L, R6, R7 and R8 are defined herein. The present invention also relates to methods of treating pain using these compounds and pharmaceutical compositions including these compounds.
Type:
Grant
Filed:
September 15, 2006
Date of Patent:
March 25, 2008
Assignee:
Abbott Laboratories Inc.
Inventors:
Guo Zhu Zheng, Brian S. Brown, Sean C. Turner, Tammie K. White, Robert G. Schmidt, John R. Koenig, Chih-Hung Lee
Abstract: Systems and compositions comprising zotarolimus that are safer, more effective and produce less inflammation than rapamycin and paclitaxel systems are disclosed. Medical devices comprising supporting structures capable of containing or supporting a pharmaceutically acceptable carrier or excipient, which carrier or excipient can contain one or more therapeutic agents or substances, with the carrier including a coating on the surface thereof, and the coating having the therapeutic compounds, including, for example, drugs. Supporting structures for the medical devices that are suitable for use in this invention include coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature.
Type:
Application
Filed:
March 22, 2006
Publication date:
September 7, 2006
Applicant:
Abbott Laboratories, Inc.
Inventors:
John Toner, Sandra Burke, Keith Cromack
Abstract: The invention relates to a method for detecting specific target-cells in a simple and time saving way, using paramagnetic particles, antibodies recognizing the Fc portions of target-cell associating antibodies and target-cell associating antibodies directed to specific antigen determinants in the target-cell membranes. Incubation of the cell suspension with a mild detergent and/or second set of antibodies or antibody fragments, prelabeled or not with fluorescent agents, metallocolloids, radioisotopes, biotincomplexes or certain enzymes allowing visualization, with dramatically increase the specificity of the method. The method can further be used for isolation of the target-cells by magnetic field application and kit for performing the method according to the invention is described.