Abstract: The present invention provides for methods of using guide wires adapted for passage across a heart valve. The guide wires have an increased diameter and a shorter, relatively floppy distal tip; the increased diameter providing improved pushability to facilitate positioning in a blood jet and passage through a heart valve. The distal tip comprises a section of rectangular cross-section that, in conjunction with the decreased tip length, causes the distal tip to vibrate, or “dance”, when positioned within a blood jet at the outlet of a heart valve. This vibratory motion may be used to position the distal tip within the blood jet, thus facilitating passage through the valve without damage to leaflets of the valve or emboli generation.

Abstract: A stent comprises a tubular flexible body composed of a web structure that is expandable from a contracted delivery configuration to a deployed configuration and that comprises neighboring web patterns of alternating concavities extending circumferentially and adjoined by X-shaped transition sections. The web pattern may comprise either arcuate struts interconnected by bends, or a plurality of substantially straight sections with the transition sections formed by the junctions between pairs of adjacent bends of opposite curvatures.

Abstract: Apparatus and methods for stenting are provided comprising a stent attached to a porous biocompatible material that is permeable to endothelial cell ingrowth, but impermeable to release of emboli of predetermined size. Preferred stent designs are provided, as well as preferred manufacturing techniques. Apparatus and methods are also provided for use at a vessel branching. Moreover, embodiments of the present invention may comprise a coating configured for localized delivery of therapeutic agents. Embodiments of the present invention are expected to provide enhanced embolic protection, improved force distribution, and improved recrossability, while reducing a risk of restenosis and thrombus formation.

Abstract: Apparatus and methods for stenting are provided comprising a stent attached to a porous biocompatible material that is permeable to endothelial cell ingrowth, but impermeable to release of emboli of predetermined size. Preferred stent designs are provided, as well as preferred manufacturing techniques. Apparatus and methods are also provided for use at a vessel branching. Moreover, embodiments of the present invention may comprise a coating configured for localized delivery of therapeutic agents. Embodiments of the present invention are expected to provide enhanced embolic protection, improved force distribution, and improved recrossability, while reducing a risk of restenosis and thrombus formation.

Abstract: The present invention refers to medical devices comprising a modified polyamide or to modified polyamides or modified polyamide elastomers with the polyamides having high flexibility and high stress resistance, especially tensile strength or tear resistance, in addition to the good physical characteristics of the known polyamide elastomers.

Abstract: A stent is configured having a tubular, flexible body. The body of the stent has a wall which is formed by a web structure. The stent further contains a portion with radiopaque material. This radiopaque material is integrated in the material of the body of the stent.

Abstract: The present invention provides a stent comprising a tubular flexible body having a wall with a web structure that is expandable from a contracted delivery configuration to deployed configuration. The web structure comprises a plurality of neighboring web patterns, where each web patterns is composed of adjoining webs, and the web patterns are interconnected by connection elements. Each adjoining web comprises a central section interposed between two lateral sections to form concave or convex configurations.

Abstract: A stent comprises a tubular flexible body composed of a web structure that is expandable from a contracted delivery configuration to a deployed configuration and that comprises neighboring web patterns of alternating concavities extending circumferentially and adjoined by X-shaped transition sections. The web pattern may comprise either arcuate struts interconnected by bends, or a plurality of substantially straight sections with the transition sections formed by the junctions between pairs of adjacent bends of opposite curvatures.

Abstract: The present invention involves porous polymer membranes, suitable for use in medical implants, having controlled pore sizes, pore densities and mechanical properties. Methods of manufacturing such porous membranes are described in which a continuous fiber of polymer is extruded through a reciprocating extrusion head and deposited onto a substrate in a predetermined pattern. When cured, the polymeric material forms a stable, porous membrane suitable for a variety of applications, including reducing emboli release during and after stent delivery, and providing a source for release of bioactive substances to a vessel or organ and surrounding tissue.

Abstract: Apparatus for delivering and deploying an expandable stent having a protection sheath within a blood vessel is provided. The apparatus comprises a fluid pressure device that is coupled with a retraction device for the protection sheath, wherein the stent is automatically deployed by the fluid pressure device after retraction of the protection sheath.

Abstract: The present invention provides a stent comprising a tubular flexible body having a wall with a web structure that is expandable from a contracted delivery configuration to deployed configuration. The web structure comprises a plurality of neighboring web patterns, where each web patterns is composed of adjoining webs, and the web patterns are interconnected. Each adjoining web comprises a central section interposed between two lateral sections to form concave or convex configurations.

Abstract: The present invention relates to a catheter having a soft distal tip that can be manufactured at lower cost than catheters in the prior art. In one embodiment, the catheter is produced by coupling a soft sleeve to the distal end of a catheter tube. The sleeve may affixed to the catheter tube under temperature and pressure conditions that cause the proximal end of the sleeve to taper against the outer surface of the catheter tube, avoiding or minimizing discontinuities in the insertion profile of the catheter, and that also cause the inner wall of the sleeve to taper against the distal end of the catheter tube, avoiding or minimizing discontinuities in the lumen of the catheter.

Abstract: A method for connecting a catheter balloon with a catheter shaft of a balloon catheter that improves the welding quality of a weld between the catheter balloon and the catheter shaft of the balloon catheter. Preferably, a welding energy absorbing device is arranged, preferably in the form of a coloured tubing, in the area of a fixation site after attaching a pre-fixation and then to irradiate this welding energy absorbing device with the radiation energy to carry out the welding. After the welding the pre-fixation and the welding energy absorbing device are removed.

Abstract: The present invention relates to an endoprosthesis having a plurality of web rings coupled by connectors, which include two or more essentially parallel struts and a foot extension protruding from one of the struts. An endoprosthesis constructed according to the principles of the present invention provides an elevated degree of scaffolding to a body lumen while retaining an acceptable degree of flexibility.

Abstract: A stent delivery system delivers a self-expanding stent to a predetermined location in a body lumen. The delivery system has a catheter body, a retractable outer sheath and a proximal retraction handle connected to a proximal end of the catheter body. The catheter body carries the stent near a distal end of the catheter body for transporting the stent for deployment. The sheath surrounds and contains the stent in a delivery configuration where the stent has a reduced radius along its entire axial length. The sheath has an outer tube a separate inner tube. The outer tube has a distal end portion surrounding the stent along its entire length and a proximal end portion connected to the retraction handle. The inner tube is disposed concentrically within the outer tube and has a distal end portion surrounding the stent only along a part of its entire length.

Abstract: The present invention provides a drug-coated stent comprising a tubular flexible body having a wall with a web structure that is expandable from a contracted delivery configuration to deployed configuration. The web structure comprises a plurality of neighboring web patterns, where each web patterns is composed of adjoining webs, and the web patterns are interconnected by transition sections. Each adjoining web comprises a central section interposed between two lateral sections to form concave or convex configurations.

Abstract: The apparatus is provided for sealing a vascular puncture tract by forming the autologous plug within the puncture tract, and extruding that plug into the puncture tract. The apparatus of the present invention forms an autologous blood plug by drawing blood into the apparatus from a vessel, mixing a blood congealing agent with the drawn blood, and ejecting a plug formed from the clotted blood within the puncture tract. Also provided are various closure elements to isolate the drawn blood from the vessel during mixture with the blood congealing agent, and to facilitate placement of the apparatus relative to the vessel.

Abstract: The present invention refers to medical devices comprising a modified Co-Polymer or to the modified Co-Polymer itself having high flexibility and high stress resistance, especially tensile strength or tear resistance, in addition to the good physical characteristics of a Block-Co-Polymers of a polyamide and a polycarbonate, either polycarbonate diol or polycarbonate diamine.

Abstract: The present invention provides a stent comprising a tubular flexible body having a wall with a web structure that is expandable from a contracted delivery configuration to deployed configuration. The web structure comprises a plurality of neighboring web patterns, where each web patterns is composed of adjoining webs, and the web patterns are interconnected by transition sections. Each adjoining web comprises a central section interposed between two lateral sections to form concave or convex configurations. A delivery system for the stent is also provided.

Abstract: The present invention provides a stent comprising a tubular flexible body having a wall with a web structure that is expandable from a contracted delivery configuration to deployed configuration. The web structure comprises a plurality of neighboring web patterns, where each web patterns is composed of adjoining webs, and the web patterns are interconnected by connection elements. Each adjoining web comprises a central section interposed between two lateral sections to form concave or convex configurations. A delivery system for the stent is also provided.