Abstract: Disclosed are methods of providing nutrition to infants, as well as sterilized liquid protein supplements including extensively hydrolyzed casein for use with human milk and other infant feeding formulas. The sterilized liquid protein supplements have a low pH, thereby inhibiting protein denaturation and reducing microbial growth.
Type:
Application
Filed:
September 19, 2018
Publication date:
January 17, 2019
Applicant:
ABBOTT LABORATORIES
Inventors:
CATHERINE S. LAMB, STEVEN T. LUEBBERS, KANDICE T. TUCKER, PAUL W. JOHNS, BRIDGET BARRETT-REIS
Abstract: Disclosed embodiments provide nutritional compositions and methods of enhancing maturation of an infant's brain. The methods include the step of administering to the infant a nutritional composition comprising a protein with a degree of hydrolysis of 10% to 75% in combination with at least one of a monoglyceride, a free fatty acid, a salt of a free fatty acid, a phospholipid, and cholesterol.
Type:
Application
Filed:
December 27, 2016
Publication date:
January 17, 2019
Applicant:
ABBOTT LABORATORIES
Inventors:
TAPAS DAS, MUSTAFA VURMA, CHRON-SI LAI, PAUL JOHNS
Abstract: Abstract: A method of preparing a protein hydrolysate using extrusion technology is provided. An intact protein source and a protease component are added to an extruder and mixed therein to form a slurry including a protein hydrolysate having a degree of hydrolysis of 5% to 30%. The slurry has a total protein content of at least 30% based on the weight of solids in the slurry. A protein hydrolysate accordingly produced is also claimed.
Abstract: Disclosed embodiments provide a method of enhancing maturation of a lung, brain, or both, in an infant. The method includes the step of administering to the infant a nutritional composition comprising a protein with a degree of hydrolysis of 10% to 75%. Also disclosed are methods for reducing the incidence of necrotizing enterocolitis in an individual. In addition, the disclosed embodiments provide a method for the prevention, delay of progression, or the treatment of a circulatory disorder characterized by inadequate blood flow to the brain or lung.
Type:
Application
Filed:
December 27, 2016
Publication date:
January 3, 2019
Applicant:
ABBOTT LABORATORIES
Inventors:
TAPAS DAS, MUSTAFA VURMA, CHRON-SI LAI, PAUL JOHNS
Abstract: Provided herein are assays and kits useful for avoiding “prozone phenomenon” or “hook effect” and which expand the range of accurately measurable analyte concentrations.
Type:
Application
Filed:
August 8, 2018
Publication date:
January 3, 2019
Applicant:
ABBOTT LABORATORIES
Inventors:
Barry L. DOWELL, Susan GAYDA, Qiaoqiao RUAN, Joseph P. SKINNER, Sergey Y. TETIN
Abstract: Stent delivery system having a contracted delivery configuration and an expanded deployed configuration is provided. The stent delivery system includes a stent having a plurality of expandable elements and a plurality of interstices disposed between adjacent expandable elements, and a delivery catheter having an inflatable balloon including creases extending non-uniformly within the interstices of the stent in the contracted delivery configuration. Each crease defines a maximum radial height within a corresponding interstice, and the maximum radial heights of the creases vary. A method for stenting at a target site within a patient's vessel including providing a stent delivery system is also provided.
Abstract: A reagent manager for a diagnostic analyzer system includes a reagent manager housing, a high-speed reagent bottle spinning device, a processor, and a memory. The reagent manager housing is for housing reagent bottles. The high-speed reagent bottle spinning device is disposed within the reagent manager housing for spinning at least one of the reagent bottles. The processor is in electronic communication with the high-speed reagent bottle spinning device. The memory is in electronic communication with the processor. The memory includes programming code for execution by the processor. The programming code is configured to spin the high-speed reagent bottle spinning device to spin the at least one reagent bottle to remove microparticles from a bottom surface of a septum of the at least one reagent bottle.
Abstract: A centrifuge to which sample tubes can be introduced while the centrifuge is in motion. The centrifuge comprises a carousel having an upper portion and a lower portion. The upper portion of the carousel has a plurality of positions for sample tubes for a centrifugation operation, a plurality of drive mechanisms attached to the upper portion of the carousel, a movable element mounted upon each drive mechanism, the movable element capable of traversing the length of the drive mechanism when the drive mechanism is actuated, a sample tube-holding assembly comprising a sample tube holder and a bearing attached to each movable element, and at least one balancing element capable of contributing to a force vector that cancels an imbalance vector generated by rotation of the centrifuge.
Abstract: A method for closing a tissue puncture, where the method includes tensioning a suture loop disposed within a vascular tissue of a patient, the suture loop having two free ends and a knot disposed on one of the free end. Those two free ends are disposed through a suture snare comprising a snare. Following detachment of the suture snare from the two free ends, the knot is advanced to close the suture loop and a cutting member is advance towards the knot and the two free ends are cut.
Type:
Grant
Filed:
April 25, 2016
Date of Patent:
December 4, 2018
Assignee:
ABBOTT LABORATORIES
Inventors:
Mike S. Dana, Rob M. George, T. Daniel Gross, Maurice Marthaler, Dawn Ma, Jim Swett
Abstract: A nutritional supplement powder and method of supplementing the nutritional value of a food or beverage is provided. The nutritional supplement powder includes a protein system, vitamins, minerals, and fiber. The protein system has a water solubility of at least about 70% at room temperature. The nutritional supplement powder is essentially free of divalent ions of copper, iron, and zinc, and is also essentially free of vitamin C. When added to a food or beverage, the nutritional supplement powder does not substantially change the organoleptic properties of the food or beverage.
Abstract: The present disclosure provides methods, kits, and compositions for detecting subject anti-HCV antibodies in a sample using NS3 capture peptides. In certain embodiments, at least two NS3 helicase (NS3h) capture peptides and at least two conjugate peptides (e.g., NS3h conjugate peptides) are employed together, which allows for a broad dynamic range of subject antibody detection in a one-step type assay. In other embodiments, methods are provided of detecting NS3-specific subject antibodies without the use of a reducing agent. In some embodiments, NS3-specific subject antibodies are detected with a ‘double shot’ of NS3 conjugate peptide (e.g., conjugate peptide added to a sample both before and after washing).
Type:
Grant
Filed:
October 28, 2015
Date of Patent:
October 2, 2018
Assignee:
Abbott Laboratories
Inventors:
Anthony S. Muerhoff, John Prostko, Chris Marohnic
Abstract: A method for delivering a closure element to an opening formed in a wall of a body lumen. The method includes inserting a distal end region of an apparatus into the opening in the wall of the body lumen, moving a third grasping portion toward the first grasping portion to limit movement of the distal end of the apparatus relative to the opening in the wall of the body lumen, and moving a second grasping portion toward the first grasping portion to advance the closure element distally. The second grasping portion and third grasping portion are movable toward the first grasping portion.
Type:
Grant
Filed:
June 8, 2015
Date of Patent:
October 2, 2018
Assignee:
ABBOTT LABORATORIES
Inventors:
Erik K. Walberg, Timothy C. Reynolds, Brian A. Ellingwood, Kai Yenkai Jair, Anthony J. Pantages
Abstract: Methods for improving the visual processing of a healthy infant by administering a composition comprising RRR-alpha-tocopherol to the infant are disclosed. Methods for improving the visual acuity of a healthy infant by administering a composition comprising RRR-alpha-tocopherol to the infant are also disclosed. Methods for improving the development of the visual processing, visual acuity, or both, of an infant by administering a composition comprising RRR-alpha-tocopherol to the infant are also disclosed.
Type:
Application
Filed:
May 11, 2018
Publication date:
September 13, 2018
Applicant:
ABBOTT LABORATORIES
Inventors:
MATTHEW KUCHAN, CHRON-SI LAI, JACQUELINE BOFF
Abstract: Provided herein are assays and kits useful for avoiding “prozone phenomenon” or “hook effect” and which expand the range of accurately measurable analyte concentrations.
Type:
Grant
Filed:
September 2, 2015
Date of Patent:
September 11, 2018
Assignee:
ABBOTT LABORATORIES
Inventors:
Barry L. Dowell, Susan Gayda, Qiaoqiao Ruan, Joseph P. Skinner, Sergey Y. Tetin
Abstract: Liquid nutritional compositions that include functional ingredients such as beta-hydroxy-beta-methylbutyrate, docosahexaenoic acid, and lutein are disclosed. The nutritional compositions are useful to promote at least one of physical performance (e.g., body composition, muscle mass, muscle strength) and cognitive function (e.g., focus, attention, alertness, executive function) in an individual. The functional ingredients are incorporated into the nutritional composition in such a way that they do not adversely affect the desirable properties of the nutritional composition such as, for example, nutritional value, stability, solubility, taste, and mouthfeel.