Abstract: The present invention provides certain (substituted carbocyclic aryl)amidoalkyl-and (substituted heterocyclic aryl)amidoalkyl-N-Hydroxy urea compounds which inhibit lipoxygenase enzyme activity and are thus useful in the treatment of allergic and inflammatory disease states.

Abstract: R(+)-2-[4-[(tetrahydro-2-furanyl)carbonyl]-1-piperazinyl]-6,7-dimethoxy-4-q uinazolinamine hydrochloride or a pharmaceutically acceptable salt or hydratet hereof (terazosin), substantially free of the S(-)-enantiomer.

Abstract: This invention concerns certain diethyl- or dipropylacetic acid salts of sodium valproate which have physiological properties similar to those of valproic acid or sodium valproate but show highly superior stability characteristics.

Abstract: The present invention provides for novel homogeneous immunoassay systems involving complement-mediated lysis of marker-encapsulating lipid vesicles (liposomes) for detection of analyte in a fluid sample. These systems do not require the separation of unbound antigens and/or antibody conjugates yet provide highly sensitive procedures for analyte detection. Liposomes containing a marker, are coupled to antibody fragments in a way which confers the liposomes with immunological specificity yet avoids sensitizing the liposomes to complement mediated lysis in the absence of analyte. Antibody sensitized liposomes (the first reagent) are sequentially incubated with an analyte-containing sample, and optionally "dummy" liposomes, which do not contain encapsulated marker, a second antibody (the second reagent), and finally with a complement source such as plasma. Complement is activated by the liposome-antibody-antigen-second antibody complex causing liposome lysis and a concomitant release of marker.

Abstract: A catheter adapter of the type wherein compression applied to the catheter provides a retention force thereon and wherein notches are provided on the adapter for wrapping the catheter around the adapter in a manner such that a force applied to the catheter does not constitute a catheter separating force.

Abstract: The present invention relates to a process for the preparation of a compound of the formula: ##STR1## wherein R.sub.1 is selected from the group consisting of hydrogen, loweralkyl, loweralkoxy-substituted loweralkyl, lower alkenyl, lower alkynyl, cycloalkyl and cycloalkylalkyl; R.sub.2 is selected from the group consisting of hydrogen, loweralkyl, loweralkoxy-substituted loweralkyl, halogen and loweralkoxy; R.sub.3 is selected from hydrogen, loweralkyl, and halogen; R* and R** are independently selected from loweralkyl and P.sub.1 is hydrogen or an nitrogen-protecting group; or an acid addition salt thereof.

Abstract: An improved device for performing agglutination reactions is disclosed. The device has at least one chamber with a proximate zone and a distal zone in which chamber agglutination reactions can be performed. The improvement comprises utilization in the device of a layer of liquid absorbent material for controlling overall rate of liquid flow through the chamber. The layer of liquid absorbent material is selectively impregnated with a substance to form an impregnated region and a non-impregnated region wherein the non-impregnated region is liquid absorbent and the impregnated region is liquid-occlusive. A portion of the non-impregnated region is positioned within the distal zone of the chamber so that the non-impregnated region is in liquid communication with that zone.

Abstract: This invention relates to fluorescent 7-hydroxy coumarin compounds with substitutions in the 4 position having a length greater than one carbon atom. The compounds thus are related to 4-methylumbelliferone (7-hydroxy-4-methyl coumarin, or 4-MU), the detectable label used in the IM.sub.x .RTM. instrument assays (Abbott Laboratories, Abbott Park, Ill.). The substitutions in the 4 position are branched and include functional groups for coupling to biological molecules.

Abstract: A method and apparatus for maintaining the patency of a vein access device in which a dilute solution of an anticoagulant drug is slowly infused into the vein access device. The patency device includes a self-energized container and means for adding a medicament without disconnecting the patency device from the vein access device. In accordance with a preferred embodiment, a self-energized container delivers a heparin solution to the vein access device at a concentration from about 0.01 to about 0.99 international heparin units per milliliter of diluent at a flow rate from about 0.01 to about 1.0 milliliters per hour.

Abstract: A methodology is presented which relates in general to fluorescence polarization immunoassays (FPIA) and modifications of current processes wherein detection and quantification of several commonly abused or therapeutic drugs in a single biological fluid sample are determined utilizing manual or current software or related equipment to allow the sequential and simultaneous performance of more than one FPIA assay. The methodology involves combining the reagents either separately or pre-mixed, for multiple assays in a single reagent package, these reagents being used to assay quantitative amounts of each of the assay analytes in a sequential step manner. The assay being performed by mixing the sample with a combination reagent and then initiating a specific reaction for each of the separate analytes by sequentially adding a specific reagent, i.e.

Abstract: A terminal reservoir capping device according to the present invention includes a hollow member having first and second open ends. A first plug seals the first open end such that the plug is inwardly displaceable into the hollow member. A second plug seals the second open end. A chamber is defined by the hollow member and the first and second plugs. A reservoir of disinfecting fluid or therapeutic drug is provided in the chamber. Axially extending from the first end of the hollow member is a mechanism for engaging and advancing the tube connector into the chamber so as to inwardly displace the first plug into the chamber. The plug self-releases and allows dispersal of the reservoir fluid into the tube connector.

Abstract: The present invention is directed to a fluorescence polarization assay for benzoyl ecgonine and substituted benzoyl ecgonine compounds in biological fluids, and to a method of making reagents therefor. Specifically, tracers, immunogens and antibodies are disclosed. The tracers and the immunogens are made from substituted benzoyl ecgonine compounds. A fluorescein moiety is included in the tracer, while a poly(amino acid) forms a part of the immunogen. The assay is conducted by measuring the degree of polarization retention of plane polarized light that has been passed through a sample containing antiserum and tracer.

Abstract: A catheter assembly with a reciprocable obturator is disclosed which facilitates patency maintenance during intravenous therapy. The assembly includes a catheter having an elongated tubular portion defining a lumen, and an obturator assembly mounted on the catheter. The obturator assembly includes a reciprocable obturator member including an elongated obturator rod telescopically disposed within the catheter lumen. The rod is configured to cooperate with the lumen to inhibit liquid flow into the free end of the catheter. The device can be employed in conjunction with a high molecular weight, viscous fluid, in order to further inhibit ingress of liquid into the catheter.

Abstract: A non-destructive, spoilage detection device has a conveyor with a top surface, an upper edge, a lower edge, a first end, a second end, a container ingress area, a first container egress area and a second container egress area. The conveyor's top surface is inclined downwardly from the upper edge to the lower edge so that containers introduced onto the conveyor will roll from the upper edge towards the lower edge as they move toward the first end of the conveyor. Containers of non-spoiled liquid food product exit the conveyor at a first container egress area located along the lower edge of the conveyor, while containers of spoiled liquid food product exit the conveyor at a second container egress area located along the first end of the conveyor. There is also disclosed a method for utilizing the device of this invention for the non-destructive detection of spoilage of liquid food products in sealed containers.

Abstract: An improved chromatographic device and method for quantitating the activity of an enzyme utilizes a bibulous test strip as the stationary phase, an aqueous solution as the mobile phase, and a chromophore as the indicator. The enzyme activity is quantitated by transforming a substantially depletable amount of a chromogenic substrate from soluble chromogen to insoluble chromophore as the mobile phase advances, whereupon the insoluble chromophore becomes immobilized on the test strip to produce a column of color. The length and/or the intensity of the column of color are related to the activity of the enzyme. The present invention is useful for the direct determination of enzyme-analytes and for the indirect determination of analytes which can be coupled to an enzyme.

Abstract: A contact lens cleaning system has a soft tip applicator affixed to a container of lens cleaning solution and is used to apply the solution to the lenses. A supply of sterile replacement soft tip applicators are provided as a part of the system.

Abstract: An article is disclosed which comprises fibrous material which has been chemically modified such that the material's cutability using ultrasonic energy becomes facile and the material can be cut into a predetermined shape using ultrasonic energy. The article may additionally comprise fibrous material disposed between first and second fusible materials, wherein at least one of the fusible materials includes means for defining a selected line of cut, and ultrasonic energy directed through the materials along the means for defining a selected line of cut will effect cutting of the fibrous material and fusion of the fusible materials.

Abstract: A method for performing a microparticle diagnostic assay in a device having a shallow sample well for receiving a sample and reagents for forming a reaction mixture, a read well positioned adjacent to said sample well and separated from said sample well by a wall which is constructed and arranged such that when wash fluid is injected into said sample well, sample and reaction mixtures are washed from said shallow sample well, over the wall and into said read well. The steps of the method comprise forming microparticle analyte complexes in said shallow sample well; washing said microparticle analyte complexes from said shallow sample well over the wall and into said read well where a fibrous matrix retains and immobilizes said microparticle analyte complexes; adding to said read well an indicator substance capable of forming an assay signal when said microparticle analyte complexes are present; and detecting said assay signal produced by said indicator substance.