Abstract: Compounds having the formula (I) are useful for inhibiting protein kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
Type:
Grant
Filed:
March 3, 2004
Date of Patent:
January 22, 2008
Assignee:
Abbott Labortories
Inventors:
Yunsong Tong, Akiyo K. Claiborne, Gaoquan Li, Nan-Horng Lin, Hing L. Sham, Thomas J. Sowin, Zhi-Fu Tao
Abstract: A compound of the formula (I): or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, a method of antagonizing endothelin, methods for the inhibition of bone metastases, methods for the prevention of growth of new metastases, methods for the inhibition of bone turnover, and methods for the prevention of bone loss in patients, including cancer patients, using an endothelin ET-A receptor antagonist.
Type:
Grant
Filed:
August 31, 2000
Date of Patent:
April 24, 2007
Assignee:
Abbott Labortories
Inventors:
Martin Winn, Steven A. Boyd, Charles W. Hutchins, Hwan-Soo Jae, Andrew S. Tasker, Thomas W. von Geldern, Jeffrey A. Kester, Bryan K. Sorensen, Bruce G. Szczepankiewicz, Kenneth J. Henry, Gang Liu, Steven J. Wittenberger, Steven A. King, Todd J. Janus, Robert J. Padley
Abstract: Abstract of the Disclosure The present invention provides a stent comprising a tubular flexible body having a wall with a web structure that is expandable from a contracted delivery configuration to deployed configuration. The web structure comprises a plurality of neighboring web patterns, where each web patterns is composed of adjoining webs, and the web patterns are interconnected. Each adjoining web comprises a central section interposed between two lateral sections to form concave or convex configurations.
Abstract: A method for determining the concentration of an analyte in tissues. The method involves compensating for a change in the value of an optical property of the tissues, such as, for example, the scattering coefficient, resulting from a change in the hydration status of the tissues.
Type:
Grant
Filed:
July 28, 2000
Date of Patent:
October 21, 2003
Assignee:
Abbott Labortories
Inventors:
Omar S. Khalil, Johannes Sake Kanger, Reneā² Alexander Bolt, Frits Frans Maria de Mul
Abstract: A method for the treatment of obesity in a human in need of such treatment which comprises administration to the human of a therapeutically effective amount of a compound of formula I
including enantiomers and pharmaceutically acceptable salts thereof, in which R1 and R2 are independently H or methyl, and a therapeutically effective amount of a compound of formula II
wherein the compound of formula I and the compound of formula II are administered simultaneously, separately or sequentially.
Type:
Grant
Filed:
December 16, 1998
Date of Patent:
June 11, 2002
Assignee:
Abbott Labortories
Inventors:
David John Heal, Helen Christine Jackson