Patents Assigned to Abbott Point of Care Inc.
  • Multiple hybrid immunoassay
    Patent number: 9267939
    Abstract: The invention relates to compositions and methods for the immunoassay of an analyte of interest. The analyte is detected in an immunoassay using three or more antibodies, wherein each antibody specifically binds to a different epitope on the analyte. When the analyte of interest in a clinical marker for an acute disease, the detection of the analyte by immunoassay is a diagnosis of the occurrence of the disease.
    Type: Grant
    Filed: November 15, 2013
    Date of Patent: February 23, 2016
    Assignee: Abbott Point of Care Inc.
    Inventors: John Lewis Emerson Campbell, Pamela Anne Frank, Meghan Elizabeth Hawkes, Shannon Reishma Lobin, Cary James Miller, Zhen Yang
  • METHOD AND APPARATUS FOR ANALYZING INDIVIDUAL CELLS OR PARTICULATES USING FLUORESCENT QUENCHING AND/OR BLEACHING
    Publication number: 20160047797
    Abstract: A method for analyzing a blood sample is provided that includes the steps of: providing a blood sample having one or more of each first and second constituents; admixing a colorant with the sample, which colorant is operative to cause the first constituents and second constituents to fluoresce and absorb light; illuminating at least a portion of the sample; e) imaging a portion of the sample; determining a fluorescence value for each the first constituents and second constituents; determining an optical density value for each of the first constituents and second constituents; and identifying the first constituents and the second constituents using the determined fluorescence and optical density values.
    Type: Application
    Filed: March 30, 2015
    Publication date: February 18, 2016
    Applicant: ABBOTT POINT OF CARE, INC.
    Inventors: Robert A. Levine, Stephen C. Wardlaw, Niten V. Lalpuria, Darryn W. Unfricht
  • Glutamate oxidase mutagenesis for diagnostic testing
    Patent number: 9249450
    Abstract: The described invention provides a method of generating a catalytically active oxidase enzyme preparation. The described invention also provides a means of generating reagents for a protease detection sensor which can use colorimetric, fluorescent, or electrochemical detection. Further, the invention describes a system for a protease detecting sensor.
    Type: Grant
    Filed: March 12, 2014
    Date of Patent: February 2, 2016
    Assignee: Abbott Point of Care Inc.
    Inventors: Dan Wang, G. Bruce Collier
  • Magnetic immunosensor and method of use
    Patent number: 9233370
    Abstract: The present invention provides apparatus and methods for the rapid determination of analytes in liquid samples by immunoassays incorporating magnetic capture of beads on a sensor capable of being used in the point-of-care diagnostic field.
    Type: Grant
    Filed: August 5, 2011
    Date of Patent: January 12, 2016
    Assignee: ABBOTT POINT OF CARE INC.
    Inventors: Cary James Miller, Jinghua Hu
  • Methods and devices for determining sensing device usability
    Patent number: 9224312
    Abstract: Methods and devices for determining sensing device usability, e.g., for point of care immunoassay devices. In one embodiment, the invention is to a method of determining device usability, comprising the steps of providing a device comprising a first electrical pad; a second electrical pad; and a continuous polymer layer contacting at least a portion of the first and second electrical pads; applying a potential across the first and second electrical pads; measuring an electrical property associated with the continuous polymer layer; and determining whether the measured electrical property associated with the continuous polymer layer has exceeded a threshold level associated with the device usability.
    Type: Grant
    Filed: June 29, 2012
    Date of Patent: December 29, 2015
    Assignee: Abbott Point of Care Inc.
    Inventors: Glenn Martin, Tian-Xian Zhao, Steven Breeze, Craig Jeffrey, Stephen Lee Snyder
  • Method and device for immunoassay using nucleotide conjugates
    Patent number: 9207246
    Abstract: A composition of matter for use in an immunoassay devices and method comprising a signal antibody, e.g., FAB fragment, covalently linked to a first nucleotide; and one or more signal elements, e.g., signal enzymes such as ALP or fluorescent dyes, each covalently linked to a second nucleotide, wherein the first nucleotide has one or more repeated sequences, and the second nucleotide is bound to one of the one or more repeated sequences on said first nucleotide, and wherein the ratio of the signal antibody to the signal element is controlled by the number of repeated sequences.
    Type: Grant
    Filed: April 18, 2013
    Date of Patent: December 8, 2015
    Assignee: Abbott Point of Care Inc.
    Inventors: G. Bruce Collier, Cary James Miller
  • Methods and devices for determining sensing device usability
    Patent number: 9201034
    Abstract: Methods and devices for determining sensing device usability, e.g., for self-monitoring and point of care devices. In one embodiment, the invention is to a method of determining device usability, comprising the steps of providing a device comprising a first electrical pad; a second electrical pad; and a humidity-responsive polymer layer contacting at least a portion of the first and second electrical pads; applying a potential across the first and second electrical pads; measuring an electrical property associated with the humidity-responsive polymer layer; and determining whether the measured electrical property associated with the humidity-responsive polymer layer has exceeded a humidity threshold level associated with the device usability.
    Type: Grant
    Filed: June 29, 2012
    Date of Patent: December 1, 2015
    Assignee: Abbott Point of Care Inc.
    Inventors: Glenn Martin, Yi Wang, Simon Tonks, Benjamin J. Feldman
  • Biologic fluid sample analysis cartridge with sample collection port
    Patent number: 9199236
    Abstract: A biological fluid sample analysis cartridge is provided that includes a collection port and a body. The body has one or more internal channels in selective fluid communication with the collection port. The collection port includes a collection bowl, and a slide valve assembly operable to be selectively positioned in an open position and a closed position. In the open position, the collection bowl is accessible for sample deposition, and in the closed position the collection bowl is inaccessible for sample deposition.
    Type: Grant
    Filed: December 31, 2012
    Date of Patent: December 1, 2015
    Assignee: Abbott Point of Care, Inc.
    Inventors: Igor Nikonorov, John Blum, Douglas R. Olson, Marek Turewicz
  • TSH antibodies for point-of-care immunoassay formats
    Patent number: 9199234
    Abstract: The invention relates to antibody characteristics used to design a whole blood Point of Care Thyroid Stimulating Hormone (TSH) immunoassay using an ELISA sandwich assay lacking one or more wash steps between the antigen capture, detection antibody addition and substrate introduction steps. This invention exhibits low cross reactivity with biologically similar interfering cross reacting species, such as Follicle Stimulating Hormone (FSH), Luteinizing Hormone (LH) and Chorionic Gonadotropin (CG).
    Type: Grant
    Filed: November 29, 2011
    Date of Patent: December 1, 2015
    Assignee: Abbott Point of Care Inc.
    Inventors: Dan Wang, Gordon Bruce Collier, Joseph P. Skinner, Qiaoqiao Ruan, Sergey Y. Tetin
  • Biologic fluid analysis cartridge with deflecting top panel
    Patent number: 9199233
    Abstract: A cartridge for analyzing a biologic fluid sample is provided that includes a base plate, a sample inlet port, a first chamber wall, a second chamber wall, and an optically transparent cover panel disposed in contact with the first and second chamber walls. The base plate has a body with a chamber surface, a body passage, and a chamber entry passage. The body passage is in fluid communication with the chamber entry passage, and the chamber entry passage extends through to the chamber surface. The sample inlet port has an inlet passage in fluid communication with the body passage. The first and second chamber walls each have a height extending outwardly from the chamber surface, and the two walls are spaced apart from one another. The cover panel is sufficiently flexible to deflect and contact a central region of the chamber surface.
    Type: Grant
    Filed: March 31, 2011
    Date of Patent: December 1, 2015
    Assignee: ABBOTT POINT OF CARE, INC.
    Inventor: Stephen C. Wardlaw
  • TSH immunoassays and processes for performing TSH immunoassays in the presence of endogenous contaminants in restricted wash formats
    Patent number: 9201078
    Abstract: The invention relates to low wash Thyroid Stimulating Hormone (TSH) immunoassays using an ELISA sandwich assay having limited or no wash step between the antigen capture, detection antibody addition and substrate introduction steps. This invention exhibits low cross reactivity with biologically similar interfering cross reacting species, such as Follicle Stimulating Hormone (FSH), Luteinizing Hormone (LH) and Chorionic Gonadotropin (CG).
    Type: Grant
    Filed: November 29, 2011
    Date of Patent: December 1, 2015
    Assignee: Abbott Point of Care Inc.
    Inventors: Dan Wang, Gordon Bruce Collier, Joseph P. Skinner, Qiaoqiao Ruan, Sergey Y. Tetin
  • Reader devices for optical and electrochemical test devices
    Patent number: 9194859
    Abstract: This invention relates generally to devices and methods for performing optical and electrochemical assays and, more particularly, to devices having optical and electrochemical detectors and to methods of performing optical and electrochemical assays using such devices. The present invention is particularly useful for performing immunoassays and/or electrochemical assays at the point-of-care.
    Type: Grant
    Filed: December 21, 2012
    Date of Patent: November 24, 2015
    Assignee: Abbott Point of Care Inc.
    Inventors: Pierre Emeric, Graham Davis, Thomas Ewart, Sergey Gershtein
  • FORMATION OF IMMOBILIZED BIOLOGICAL LAYERS FOR SENSING
    Publication number: 20150275261
    Abstract: The invention is directed to enzyme immobilization compositions comprising: one or more enzymes, a humectant, an acrylic-based monomer, a water-soluble organic photo-initiator and a water-soluble acrylic-based cross-linker in a substantially homogeneous aqueous mixture. The invention is also directed to methods for forming sensors comprising such compositions and to apparati for forming arrays of immobilized layers on an array of sensors by dispensing such compositions onto a substrate.
    Type: Application
    Filed: November 21, 2014
    Publication date: October 1, 2015
    Applicant: ABBOTT POINT OF CARE INC.
    Inventors: Gordon Bruce Collier, Jason Andrew Macleod, Anjulia Wong, Attila Csaba Nemeth
  • Integrated test device for optical detection of microarrays
    Patent number: 9140693
    Abstract: This invention relates generally to devices and methods for performing optical and electrochemical assays and, more particularly, to testing devices having an optically readable microspot array and/or an electrochemical detector and to methods of performing microspot arrays and electrochemical assays using such devices. The present invention is particularly useful for performing immunoassays and/or electrochemical assays at the point-of-care.
    Type: Grant
    Filed: December 21, 2012
    Date of Patent: September 22, 2015
    Assignee: Abbott Point of Care Inc.
    Inventors: Thomas Ewart, Graham Davis, Pierre Emeric, Sergey Gershtein, Smitha Sutrala, Katrina Di Tullio
  • Sample Metering Device and Assay Device with Integrated Sample Dilution
    Publication number: 20150258546
    Abstract: In one embodiment, the invention is to a sample metering device, comprising a sample holding chamber oriented between a sample entry port and a sample extraction unit, wherein a portion of said extraction unit defines a metered volume of a sample. A diluent may be transported over and/or through the extraction unit to form a diluted sample for sample analysis. In another embodiment, the invention is to an apparatus and method for rapid determination of analytes in liquid samples by various assays including immunoassays incorporating a sample dilution feature, capable of being used in the point-of-care diagnostic field is provided. The devices and methods of the invention preferably are well-suited for high range sample dilution.
    Type: Application
    Filed: May 28, 2015
    Publication date: September 17, 2015
    Applicant: Abbott Point of Care Inc.
    Inventor: Cary James Miller
  • Sample Metering Device and Assay Device with Integrated Sample Dilution
    Publication number: 20150247840
    Abstract: In one embodiment, the invention is to a sample metering device, comprising a sample holding chamber oriented between a sample entry port and a sample isolation unit and having a diluent introduction port disposed therebetween for introduction of a diluent into the sample holding chamber. The volume within the sample holding chamber between the diluent introduction port and the sample isolation unit defines a metered volume of a sample for analysis. In another embodiment, the invention is to an apparatus and method for rapid determination of analytes in liquid samples by various assays including immunoassays incorporating a sample dilution feature, preferably suitable for low range sample dilution, and preferably capable of being used in the point-of-care diagnostic field.
    Type: Application
    Filed: May 14, 2015
    Publication date: September 3, 2015
    Applicant: ABBOTT POINT OF CARE INC.
    Inventor: Cary James Miller
  • Method and apparatus for automated platelet identification within a whole blood sample from microscopy images
    Patent number: 9082166
    Abstract: A method and apparatus for identifying platelets within a whole blood sample. The method includes the steps of: a) adding at least one colorant to the whole blood sample, which colorant is operable to tag platelets; b) disposing the blood sample into a chamber defined by at least one transparent panel; c) imaging at least a portion of the sample quiescently residing within the chamber to create one or more images; and d) identifying one or more platelets within the sample using an analyzer adapted to identify the platelets based on quantitatively determinable features within the image using a analyzer, which quantitatively determinable features include intensity differences.
    Type: Grant
    Filed: December 28, 2012
    Date of Patent: July 14, 2015
    Assignee: Abbott Point of Care, Inc.
    Inventors: Changhua Yu, Min Xie, Yiming Wu
  • TSH immunoassays employing scavenging reagents for cross-reacting endocrine glycoprotein hormone analogues
    Patent number: 9068994
    Abstract: Thyroid Stimulating Hormone (TSH) immunoassays are performed using an ELISA sandwich assay that employs scavenging or sacrificial beads for reducing interference caused by cross-reacting endocrine glycoprotein hormone analogs such as Follicle Stimulating Hormone (FSH), Luteinizing Hormone (LH) and Chorionic Gonadotropin (CG).
    Type: Grant
    Filed: November 22, 2013
    Date of Patent: June 30, 2015
    Assignee: ABBOTT POINT OF CARE INC.
    Inventors: G. Bruce Collier, John Emegbero Omakor
  • Method and apparatus for compressing imaging data of whole blood sample analyses
    Patent number: 9064301
    Abstract: A method and apparatus for analyzing white blood cells (WBCs) within a whole blood sample quiescently residing within a chamber is provided. The chamber is defined by at least one transparent panel, and the whole blood sample includes at least one colorant operable to differentially identify at least one WBC type from another WBC type within the sample. The method includes the steps of: a) creating at least one image of the sample quiescently residing within the chamber; b) identifying portions of the sample image, with each portion representing a single WBC; c) compressing the sample image portions using a first compression algorithm; and d) one of compressing a remainder of the sample image not included in the portions using a second compression algorithm, or discarding the remainder.
    Type: Grant
    Filed: April 14, 2011
    Date of Patent: June 23, 2015
    Assignee: Abbott Point of Care, Inc.
    Inventors: Min Xie, Zhizhou Wang
  • Sample metering device and assay device with integrated sample dilution
    Patent number: 9061283
    Abstract: In one embodiment, the invention is to a sample metering device, comprising a sample holding chamber oriented between a sample entry port and a sample extraction unit, wherein a portion of said extraction unit defines a metered volume of a sample. A diluent may be transported over and/or through the extraction unit to form a diluted sample for sample analysis. In another embodiment, the invention is to an apparatus and method for rapid determination of analytes in liquid samples by various assays including immunoassays incorporating a sample dilution feature, capable of being used in the point-of-care diagnostic field is provided. The devices and methods of the invention preferably are well-suited for high range sample dilution.
    Type: Grant
    Filed: December 1, 2011
    Date of Patent: June 23, 2015
    Assignee: Abbott Point of Care Inc.
    Inventor: Cary James Miller