Patents Assigned to Abbott Research B.V.
  • Antibodies Against Nerve Growth Factor (NGF) With Enhanced In Vivo Stability
    Publication number: 20130295112
    Abstract: The present invention provides anti-nerve growth factor (NGF) antibodies that contain an IgG4 constant region comprising a stabilizing hinge region mutation and wherein the antibodies exhibit an unexpectedly long serum half life in cynomolgus monkeys. Pharmaceutical compositions comprising the anti-NGF antibodies, nucleic acids encoding the NGF antibodies, host cells for expressing the NGF antibodies and methods of using the antibodies for treating NGF-related diseases or conditions are also provided.
    Type: Application
    Filed: May 2, 2013
    Publication date: November 7, 2013
    Applicant: Abbott Research B.V.
    Inventor: Abbott Research B.V.
  • Antibodies against nerve growth factor (NGF) with enhanced in vivo stability
    Patent number: 8435523
    Abstract: The present invention provides anti-nerve growth factor (NGF) antibodies that contain an IgG4 constant region comprising a stabilizing hinge region mutation and wherein the antibodies exhibit an unexpectedly long serum half life in cynomolgus monkeys. Pharmaceutical compositions comprising the anti-NGF antibodies, nucleic acids encoding the NGF antibodies, host cells for expressing the NGF antibodies and methods of using the antibodies for treating NGF-related diseases or conditions are also provided.
    Type: Grant
    Filed: May 4, 2010
    Date of Patent: May 7, 2013
    Assignee: Abbott Research B.V.
    Inventors: John Powell, Duncan Casson, Mark Maginn, Wei Liu, Sandeep Dutta, Andrea Best, Jerry A. Hall
  • Humanized anti-nerve growth factor antibodies
    Patent number: 8246956
    Abstract: Method for the humanization of the VH and VL variable regions of an animal antibody of known sequence, humanized animal antibody obtainable according to the method, in particular anti-NGF and anti-TrkA humanized animal antibodies.
    Type: Grant
    Filed: July 16, 2010
    Date of Patent: August 21, 2012
    Assignee: Abbott Research B.V.
    Inventors: Antonino Cattaneo, Doriano Lamba, Sonia Covaceuszach