Abstract: Hemostatic products with improved stability are prepared from crosslinked chitosan hemostatic compositions. The crosslinked chitosan hemostatic compositions have improved stability and can be prepared into a variety of medical devices in various shapes and sizes so as to be usable for inhibiting blood flow and ooze from substantially any type of bleeding site. For example, the chitosan compositions can be prepared into hemostatic gauze pads, bandages, wrappings, wound dressings, wound coverings, wound dressings, incision dressings, sealers, sheets, rolls, combinations thereof, and the like.

Abstract: A vascular closure device comprised of a sheath-delivered expandable, umbrella-like device with structural radial members with terminal and non-terminal hooks that engage the vessel wall. Unlike other vascular closure umbrella-type devices that effect closure by opening of the umbrella to cover an opening, the present invention effects closure of the aperture with closure of the umbrella. The closure can be maintained by a retainer lock that slides down the members, causing contraction, bringing the members into a compressed configuration (e.g., a parallel orientation of linear members) and the wound edges together, permitting immediate vascular closure and healing of the blood vessel. The device can be delivered and recovered by an intravascular sheath.

Abstract: A medical device system comprising a guide catheter and a leaflet fastening applicator, the guide catheter having suitable dimensions for deployment and insertion percutaneously into a human heart in a vicinity of a heart valve, the leaflet fastening applicator having a size allowing insertion through the guide catheter and being capable of holding portions of opposing heart valve leaflets, wherein the fastening applicator comprises a pair of grasping-electrodes adapted for holding and engaging the portions of opposing heart valve leaflets together and for applying energy to fasten the portions, in which heart valve leaflets can be captured and securely fastened, thereby improving coaptation of the leaflets and improving competence of the valve.

Abstract: A generally U-shaped surgical staple comprises a base 10 and a pair of generally “L”-shaped legs 12 extending substantially perpendicularly from opposite ends of the base respectively. The legs 12 in use of the staple are bent through approximately 90° relative to the base. To effect a greater compression of the stapled tissue the legs include a penetrative portion 16 adjacent the tip and a compressive structure 30 which, due to its increased height relative to that of the penetrative portion, spreads the compressive forces of the staple further along the length of the incision being closed. The compressive portion also provides a depth stop to avoid the tip penetrating too deeply into the tissue in which it is deployed.

Abstract: A clip for closing a puncture hole in a blood vessel comprises a ring having a resiliently expandable circumference and a plurality of barbed prongs extending at least approximately in the same direction from one edge of the ring. A device for deploying such a clip is also described.

Abstract: In certain exemplary embodiments, a generally U-shaped surgical staple is provided having a base and a pair of legs extending substantially perpendicularly from opposite ends of the base respectively. The legs in use of the staple are bent through approximately 90° relative to the base. To effect a greater compression of the stapled tissue, the legs can include a penetrative portion adjacent the tip and a compressive structure which, due to its increased height relative to that of the penetrative portion, spreads the compressive forces of the staple further along the length of the incision being closed. The compressive portion also provides a depth stop to avoid the tip penetrating too deeply into the tissue in which it is deployed.

Abstract: A generally U-shaped surgical staple comprises a base 10 and a pair of generally “L”-shaped legs 12 extending substantially perpendicularly from opposite ends of the base respectively. The legs 12 in use of the staple are bent through approximately 90° relative to the base. To effect a greater compression of the stapled tissue the legs include a penetrative portion 16 adjacent the tip and a compressive structure 30 which, due to its increased height relative to that of the penetrative portion, spreads the compressive forces of the staple further along the length of the incision being closed. The compressive portion also provides a depth stop to avoid the tip penetrating too deeply into the tissue in which it is deployed.

Abstract: In certain exemplary embodiments, a generally U-shaped surgical staple is provided having a base and a pair of legs extending substantially perpendicularly from opposite ends of the base respectively. The legs in use of the staple are bent through approximately 90° relative to the base. To effect a greater compression of the stapled tissue, the legs can include a penetrative portion adjacent the tip and a compressive structure which, due to its increased height relative to that of the penetrative portion, spreads the compressive forces of the staple further along the length of the incision being closed. The compressive portion also provides a depth stop to avoid the tip penetrating too deeply into the tissue in which it is deployed.

Abstract: A clip for closing a puncture hole in a blood vessel comprises a ring 12 having a resiliently expandable circumference and a plurality of barbed prongs 14 extending at least approximately in the same direction from one edge of the ring. A device for deploying such a clip is also described.

Abstract: An introducer sheath is described. The introducer sheath may include a tubular body. The tubular body may extend from a distal end toward a proximal end. The tubular body may include a lumen. The lumen may at least partially be defined by a wall. A channel may be disposed within the wall. The channel may be configured to receive a guidewire. The tubular body may include an expandable portion expandable to increase a cross-sectional area of the lumen.

Abstract: An introducer sheath is disclosed. The introducer sheath may include a tubular portion extending between a proximal end and a distal end. The tubular portion may include an inner portion forming a lumen and an outer portion disposed partially around the inner portion. The inner portion and the outer portion may extend between the proximal end and the distal end. At least a portion of the inner portion may be exposed between the proximal end and the distal end. A method for manufacturing an introducer sheath is disclosed. A method for performing a medical procedure is disclosed.

Abstract: The present disclosure includes vessel closure devices, systems, and methods. A closure device configured to close an opening in a body lumen may include an elongate member having a distal end and a proximal end. An anchor member may be disposed on the elongate member proximate the distal end of the elongate member. A cap member may also be disposed on the elongate member a distance from the distal end of the elongate member. The anchor member and the cap member cooperate to close the opening in the body lumen.

Abstract: The present disclosure includes vessel closure devices, systems, and methods. A closure system configured to close a body lumen opening may include a handle member. A tube set configured to deliver and/or deploy a closure element may be coupled to the handle member. The closure system may also include an inner lumen with an anchor member at least partially disposed in the inner lumen. A plunger member may be movably coupled to the handle member.

Abstract: An anchor for using a closure device includes a body being configured to move from a pre-deployed state to a deployed state. In the pre-deployed state, the body has a first width aspect relative to a direction of deployment and a second width aspect in the deployed state relative to the direction of deployment, the second width aspect being greater than the first width aspect and wherein the body is formed from a rapidly eroding material configured to erode through dissolution within a body lumen.

Abstract: A closure device configured for closing an opening in a body lumen. The closure device may include a delivery sheath, a cleat, and one or more anchors. The cleat may be disposed within and move longitudinally with respect to the delivery sheath. The one or more anchors may be configured to engage tissue surrounding the body lumen opening and selectively couple to the cleat to obstruct and/or close the body lumen opening.

Abstract: A closure system is provided that may include a plurality of needle carriers each having a distal end and a proximal end and a plurality of detachable needles in which at least one of the detachable needles is detachably coupled to the distal end of one of the needle carriers. The detachable needle may be configured to resist proximal movement when deployed in a vessel wall. The closure system may further include at least one suture secured to each of the detachable needles and a guide member having a plurality of first lumens defined therein that extend distally from a proximal end of the guide member toward a distal end of the guide member in which each of the first lumens is sized to receive one of the needle carriers and one of the detachable needles coupled to the needle carrier. The first lumens may be further configured to direct the needle carrier and the detachable needle radially outward and distally away from the guide member.

Abstract: The present disclosure includes anchor members configured to locate and/or anchor tissue surrounding a body lumen opening comprising. In one implementation, the anchor member can include an elongate portion configured to be manipulated by a user and an anchor portion. In a further implementation, the anchor portion can have one or more contracted configurations capable of passing through a body lumen opening and one or more expanded configurations capable of anchoring tissue surrounding a body lumen opening.

Abstract: An introducer sheath and methods of making the introducer sheath are described. The introducer sheath may include a hub portion and a tubular portion. The tubular portion may extend from the hub portion. A lumen may extend between a proximal end and a distal end of the tubular portion. At least a portion of an inner surface and/or outer surface of the tubular member may be irregular.

Abstract: An introducer sheath and methods of making the introducer sheath are described. The introducer sheath may include a hub portion and a tubular portion. The hub portion may include a substantially non-planar valve portion in a relaxed state. The valve portion may include an aperture configured to receive a medical device. A hub portion may be formed using a forming device. An aperture may be formed through a distal surface of the valve portion. A valve portion may be formed in a cap defining a cavity sized to elastically receive a proximal end of the hub portion.

Abstract: A tissue closure device including a tissue eversion apparatus, and a first and a second, redundant closure element that are placed on the external surface of a tissue puncture wound to enhance the efficacy of closure. The first closure element and the second closure element closure are left resident on the external surface of or in proximity to the tissue puncture wound in order to provide redundancy of closure.