Abstract: The present invention is directed to antagonists of CS1 that bind to and neutralize at least one biological activity of CS1. The invention also includes a pharmaceutical composition comprising such antibodies or antigen-binding fragments thereof. The present invention also provides for a method of preventing or treating disease states, including autoimmune disorders and cancer, in a subject in need thereof, comprising administering into said subject an effective amount of such antagonists.
Type:
Grant
Filed:
June 30, 2011
Date of Patent:
May 21, 2013
Assignee:
AbbVie Biotherapeutics Inc.
Inventors:
Marna Williams, J. Yun Tso, Nicholas F. Landolfi, Gao Liu
Abstract: The present invention is directed to antagonists of CS1 that bind to and neutralize at least one biological activity of CS1. The invention also includes a pharmaceutical composition comprising such antibodies or antigen-binding fragments thereof. The present invention also provides for a method of preventing or treating disease states, including autoimmune disorders and cancer, in a subject in need thereof, comprising administering into said subject an effective amount of such antagonists.
Type:
Grant
Filed:
July 1, 2011
Date of Patent:
May 7, 2013
Assignee:
AbbVie Biotherapeutics Inc.
Inventors:
Marna Williams, J. Yun Tso, Nicholas F. Landolfi, David B. Powers, Gao Liu