Patents Assigned to AbbVie Inc.
  • Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
    Patent number: 9266877
    Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-xL protein.
    Type: Grant
    Filed: December 3, 2014
    Date of Patent: February 23, 2016
    Assignee: ABBVIE INC.
    Inventors: Le Wang, George Doherty, Xilu Wang, Zhi-Fu Tao, Milan Bruncko, Aaron R. Kunzer, Michael D. Wendt, Xiaohong Song, Robin Frey, Todd M. Hansen, Gerard M. Sullivan, Andrew Judd, Andrew Souers
  • Isolation and purification of anti-IL-13 antibodies using protein a affinity chromatography
    Patent number: 9266950
    Abstract: Disclosed herein are methods for the isolation and purification of anti-IL-13 antibodies wherein the use of an affinity chromatographic step results in an antibody composition sufficiently pure for pharmaceutical uses. The methods described herein comprise pH viral reduction/inactivation, ultrafiltration/diafiltration, affinity chromatography (e.g., Protein A affinity chromatography), ion exchange chromatography, and hydrophobic chromatography. Further, the present invention is directed toward pharmaceutical compositions comprising one or more antibodies of the present invention.
    Type: Grant
    Filed: July 9, 2013
    Date of Patent: February 23, 2016
    Assignee: AbbVie Inc.
    Inventor: Robert K. Hickman
  • Phosphine ligands for catalytic reactions
    Patent number: 9266913
    Abstract: The disclosure is directed to: (a) phosphacycle ligands; (b) methods of using such phosphacycle ligands in bond forming reactions; and (c) methods of preparing phosphacycle ligands.
    Type: Grant
    Filed: August 25, 2014
    Date of Patent: February 23, 2016
    Assignee: AbbVie Inc.
    Inventors: Shashank Shekhar, Thaddeus S. Franczyk, David M. Barnes, Travis B. Dunn, Anthony R. Haight, Vincent S. Chan
  • Synthesis of (2S,5R)-5-ethynyl-1-{N-(4-methyl-1-(4-carboxy-pyridin-2-yl)piperidin-4-yl)glycyl}pyrrolidine-2-carbonitrile
    Patent number: 9260411
    Abstract: A process for making (2S,5R)-5-ethynyl-1-{N-(4-methyl-1-(4-carboxy-pyridin-2-yl)piperidin-4-yl)glycyl}pyrrolidine-2-carbonitrile and salts thereof, and intermediates used in the process are disclosed.
    Type: Grant
    Filed: July 19, 2007
    Date of Patent: February 16, 2016
    Assignee: AbbVie Inc.
    Inventors: Todd S. McDermott, Seble H. Wagaw, Kenneth M. Engstrom, Jorge Gandarilla, Albert Kruger, Michael J. Rozema, Michael G. Fickes, Steven J. Wittenberger, Lakshmi Bhagavatula, Thomas B. Borchardt
  • Polymorph of a pharmaceutical
    Patent number: 9255092
    Abstract: A new crystalline polymorph of ritonavir and methods for its use and preparation are disclosed.
    Type: Grant
    Filed: October 14, 2013
    Date of Patent: February 9, 2016
    Assignee: AbbVie Inc.
    Inventors: John F. Bauer, Azita Saleki-Gerhardt, Bikshandarkoil A. Narayanan, Sanjay R. Chemburkar, Ketan M. Patel, Harry O. Spiwek, Philip E. Bauer, Kimberly A. Allen
  • Process for preparing antiviral compounds
    Patent number: 9255074
    Abstract: This disclosure is directed to: (a) processes for preparing compounds and salts thereof that, inter alia, are useful for inhibiting hepatitis C virus (HCV); (b) intermediates useful for the preparation of the compounds and salts; (c) pharmaceutical compositions comprising the compounds or salts; and (d) methods of use of such compositions.
    Type: Grant
    Filed: August 21, 2012
    Date of Patent: February 9, 2016
    Assignee: AbbVie Inc.
    Inventors: Shashank Shekhar, Thaddeus S. Franczyk, David M. Barnes, Travis B. Dunn, Anthony R. Haight, Vincent S. Chan
  • Neutralizing monoclonal antibodies against the Nogo-66 receptor (NgR) and uses thereof
    Patent number: 9255146
    Abstract: The subject invention relates to isolated proteins, particularly monoclonal antibodies, which bind to the Nogo-66 receptor. Specifically, these antibodies have the ability to inhibit the binding of the natural ligand of the Nogo-66 receptor and neutralize the Nogo-66 receptor. These antibodies or portions thereof of the invention are useful for detecting NgR and for inhibiting NgR activity, for example in a human suffering from a disorder in which NgR or Nogo-66 activity is detrimental.
    Type: Grant
    Filed: August 29, 2013
    Date of Patent: February 9, 2016
    Assignees: ABBVIE INC., ABBVIE DEUTSCHLAND GMBH & CO. KG
    Inventors: Mario Mezler, Achim Moeller, Reinhold Mueller, Bernhard K. Mueller, Tariq Ghayur, Eve H. Barlow, Martin Schmidt, Axel Meyer, Nicole Teusch
  • Methods for controlling the galactosylation profile of recombinantly-expressed proteins
    Patent number: 9255143
    Abstract: The present invention relates to methods for modulating the glycosylation profile of recombinantly-expressed proteins. In particular, the present invention relates to methods of controlling the galactosylation profile of recombinantly-expressed proteins by supplementing production medium, e.g., a hydrolysate-based or a chemically defined medium, with manganese and/or D-galactose.
    Type: Grant
    Filed: February 11, 2015
    Date of Patent: February 9, 2016
    Assignee: AbbVie Inc.
    Inventors: Cornelia Bengea, Lisa M. Rives, Patrick Hossler
  • Nampt and Rock Inhibitors
    Publication number: 20160031880
    Abstract: Disclosed are compounds which inhibit the activity of NAMPT, compositions containing the compounds and methods of treating diseases during which NAMPT is expressed. Disclosed are compounds which inhibit the activity of ROCK, compositions containing the compounds and methods of treating diseases during which ROCK is expressed.
    Type: Application
    Filed: October 12, 2015
    Publication date: February 4, 2016
    Applicant: ABBVIE INC.
    Inventors: Rick F. Clark, Michael L. Curtain, Todd M. Hansen, Howard R. Heyman, Helmut Mack, Michael Michaelides, Marina A. Pliushchev, Omar J. Shah, Bryan K. Sorensen, Ramzi Sweis, Chris Tse, Anil Vasudevan, Kevin R. Woller
  • Purification of antibodies using hydrophobic interaction chromatography
    Patent number: 9249182
    Abstract: Disclosed herein are compositions and methods for purifying antibody products from a sample matrix. In particular, the present invention relates to compositions and methods for purifying antibody products employing hydrophobic interaction chromatography media. In certain embodiments, the invention provides a method for reducing process-related impurities (e.g., host cell proteins), as well as product-related substances, including molecular weight variants (e.g., aggregates and fragments of the antibody product).
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: February 2, 2016
    Assignee: AbbVie, Inc.
    Inventors: Matthew Omon Herigstad, Linda E. Rich, Stephen Ming-teh Lu, Natarajan Ramasubramanyan
  • Formulations of phenyl uracil compounds
    Patent number: 9248193
    Abstract: A pharmaceutical product comprising at least one phenyl uracil-based pharmaceutically active agent or an agent of related structural type and processes for obtaining such product.
    Type: Grant
    Filed: March 16, 2012
    Date of Patent: February 2, 2016
    Assignee: AbbVie Inc.
    Inventors: Huailiang Wu, Hao Hou, Adivaraha Jayasankar, Ameesha Patel, David Beno, Eric A. Schmitt, Geoff G. Zhang
  • Anti-viral compounds
    Patent number: 9249138
    Abstract: Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.
    Type: Grant
    Filed: September 4, 2013
    Date of Patent: February 2, 2016
    Assignee: ABBVIE INC.
    Inventors: David A. Degoey, Pamela L. Donner, Warren M. Kati, Charles W. Hutchins, Allan C. Krueger, John T. Randolph, Christopher E. Motter, Preethi Krishnan, Neeta C. Mistry, Tami J. Pilot-Matias, Sachin V. Patel, Xiaoyan Li, Todd N. Soltwedel, Lissa T. Nelson
  • Medicine container, method of assembling the container, and method of dispensing the medicine from the container
    Patent number: 9241873
    Abstract: A child-resistant medication container assembly and method of dispensing the medication from the container assembly. The medication container assembly includes a blister pack with a plurality of compartments, each of which supports a medication. The container also includes a puck and a box. The blister pack compartments are aligned with openings on the puck, and the box is configured to receive and secure the puck and the blister pack such that each of the plurality of compartments is aligned with a complementary opening in the box.
    Type: Grant
    Filed: July 3, 2014
    Date of Patent: January 26, 2016
    Assignee: AbbVie Inc.
    Inventors: Guy Upchurch, John G. Finch
  • Processes for the preparation of an apoptosis-inducing agent
    Patent number: 9238652
    Abstract: Provided herein is a process for the preparation of an apoptosis-inducing agent, and chemical intermediates thereof. Also provided herein are novel chemical intermediates related to the process provided herein.
    Type: Grant
    Filed: March 4, 2015
    Date of Patent: January 19, 2016
    Assignee: AbbVie Inc.
    Inventors: Jufang Barkalow, Jean-Christophe Califano, Vincent S. Chan, Alan C. Christesen, Timothy A. Grieme, Yi-Yin Ku, Mathew M. Mulhern, Yu-Ming M. Pu
  • Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy
    Patent number: 9238619
    Abstract: The present invention relates to phenalkylamine derivatives of the formula (I) or a physiologically tolerated salt thereof. The invention relates to pharmaceutical compositions comprising such phenalkylamine derivatives, and the use of such phenalkylamine derivatives for therapeutic purposes. The phenalkylamine derivatives are GlyT1 inhibitors.
    Type: Grant
    Filed: May 20, 2014
    Date of Patent: January 19, 2016
    Assignees: AbbVie Deutschland GmbH & Co. KG, AbbVie Inc.
    Inventors: Frauke Pohlki, Udo Lange, Wilhelm Amberg, Michael Ochse, Berthold Behl, Wilfried Hornberger, Mario Mezler, Charles W. Hutchins, Sean Turner
  • Salts and crystalline forms of 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl piperazin-1-yl)-N-({3-nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide
    Patent number: 9238649
    Abstract: Salts and crystalline forms of 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({3-nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}-sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide are suitable active pharmaceutical ingredients for pharmaceutical compositions useful in treatment of a disease characterized by overexpression of one or more anti-apoptotic Bcl-2 family proteins, for example cancer.
    Type: Grant
    Filed: March 27, 2014
    Date of Patent: January 19, 2016
    Assignee: AbbVie Inc.
    Inventors: Nathaniel Catron, Shuang Chen, Yuchuan Gong, Geoff G. Zhang
  • Fed-batch methods for producing adalimumab
    Patent number: 9234032
    Abstract: The invention describes improved methods and compositions for producing a recombinant protein, e.g., an antibody, in mammalian cell culture. In addition, the invention provides improved cell culture media, including improved production media, feed solutions, and combination feeds, which may be used to improve protein productivity in mammalian cell culture.
    Type: Grant
    Filed: January 16, 2014
    Date of Patent: January 12, 2016
    Assignee: AbbVie Inc.
    Inventors: Itzcoatl A. Pla, Joseph G. Matuck, John C. Fann, Christof Schulz, Nichole A. Roy, David F. Bruton, James McIntire, Yu-hsiang D. Chang, Thomas Seewoester
  • Template for a prescription medicine container
    Patent number: D747091
    Type: Grant
    Filed: June 11, 2015
    Date of Patent: January 12, 2016
    Assignee: AbbVie Inc.
    Inventors: Guy Upchurch, John G. Finch, Lewis H. Sita, Lori K. Kim, Alexandra C. Breban-Lopez, Bhimaprasad Medhal
  • Template for a prescription medicine container
    Patent number: D747602
    Type: Grant
    Filed: June 9, 2015
    Date of Patent: January 19, 2016
    Assignee: AbbVie Inc.
    Inventors: Guy Upchurch, John G. Finch, Lewis H. Sita, Lori K. Kim, Alexandra C. Breban-Lopez
  • Template for a prescription medicine container
    Patent number: D748392
    Type: Grant
    Filed: June 11, 2015
    Date of Patent: February 2, 2016
    Assignee: AbbVie Inc.
    Inventors: Guy Upchurch, John G. Finch, Lewis H. Sita, Lori K. Kim, Alexandra C. Breban-Lopez