Abstract: The present disclosure is directed to expression vectors, comprising a weakened SV40 promoter, and recombinant mammalian cells capable of producing high levels of a polypeptide of interest, methods of generating and using such recombinant mammalian cells.
Type:
Grant
Filed:
May 20, 2016
Date of Patent:
August 21, 2018
Assignee:
AbbView Biotherapeutics Inc.
Inventors:
Taymar E. Hartman, J. Yun Tso, Yimin He