Abstract: Nitrogen oxide generating compositions are useful in the treatment of subungual infections, as NO has surprisingly been found to be able to penetrate the nail to exert an anti-fungal effect.

Abstract: A process for the production of an antigen specific antigen binding domain using a transformed host containing an expressible DNA sequence encoding the antigen specific antigen binding domain, wherein the antigen specific antigen binding domain is derived from a variable region of the immunoglobulin isotype NAR found in fish.

Abstract: An apparatus is disclosed for predicting bone fracture risk in an osteoporotic patient. The apparatus comprises a Dual X-ray Absorptiometry scanner for scanning a body area of the patient and producing a Dual X-ray Absorptiometry image of the body area, and image analysis means for analyzing pre-determined aspects of the Dual X-ray Absorptiometry image. The apparatus further comprises data comparison means comprising a database of comparative data sets from Dual X-ray Absorptiometry images of control subjects to predict the risk of bone fracture in the patient. The image analysis means preferably analyses the shape of a body past using an Achieve Shape Model or analyses the texture of a body past using Fourier Transforms and Principal Component Analysis.

Abstract: A vision exercising apparatus including a visual display device (1); a locating means (5) for locating the head of a user at a position to provide a substantially known relationship between the visual display device (1) and the field of view of the user; display position control means for actuating the visual display device (1) to display a predetermined pattern at a known display position which corresponds to a specific viewing area of the field of view of the user; user actuable response means (17) to enable a user response to be provided; further control means to control the display position control means to repeatedly display the predetermined pattern at the known display condition; and means to collate user response and to evaluate the statistical significance of the user response for that display position. A predetermined pattern can thus be displayed in the field of view of a user that requires exercising.

Abstract: Apparatus for muscular stimulation of a user includes a pressure sensor, a control unit to which pressure values sensed by the pressure sensor are fed, and a vibrational stimulator for applying vibrational stimulation. The vibrational stimulator is activated by the control unit in response to the pressure sensor sensing an applied pressure which exceeds a threshold-pressure value.

Abstract: The present invention relates to a detector module (10) for detecting ionizing radiation from an object of interest, and in particular to a computer tomography scanner utilizing a plurality of such detector modules. The detector module (10) comprises a plurality of stacked detection layers (3), wherein each layer includes a scintillator (1) capable of emitting electromagnetic radiation at optical, or near optical, wavelengths in response to interaction with the ionizing radiation (4). Each layer also includes a light sensitive solid state substrate element (2) capable of detecting the electromagnetic radiation emitted by the scintillator and of generating electrical signals thereof.

Abstract: The present invention relates to a pharmaceutical composition for the prevention of alloimmunization of a subject or the immunosuppression of a response elicited by alloimmunization of a subject or an autoimmune haemolytic disease for said composition comprising an immunologically effective epitope of a rhesus protein or an immunologically active analogue or derivative thereof.

Abstract: The present invention relates to a non-infectious nucleic acid (RNA and DNA) construct constructed to express a recombinant antibody or antibody fragment in a host cell. The antibody molecule confers protection to the host against a pathogen, allergen or toxin. The host may be any animal including a human or a fish. More specifically, the antibody may be against viral haemorrhagic septicaemia virus.

Abstract: The present invention relates to a buoyancy control system, and in particular to a buoyancy control system for controlling the buoyancy of an underwater submersible. The buoyancy control system comprises a buoyancy chamber (5) having a seawater inlet (5A) and a seawater outlet (11A), a power supply(31) used to power at least one electrical component of the system, and a hydraulic system for pumping seawater from the chamber through the outlet. The hydraulic system comprises a hydraulic pump (28) and a pressure multiplier (34), the hydraulic pump for applying pressure to the pressure multiplier, and the pressure multiplier for increasing the pressure applied thereto by the hydraulic pump, and for applying the increased pressure to seawater from the chamber to thereby pump out the seawater.

Abstract: The present invention concerns a method for reducing seepage through a leak (5) in a duct (1), the leak being defined in terms of its maximum dimension xL and its maximum width in an orthogonal direction yL and the effective size of the leak being given by formula (1): SL=(x2L+y2L)1/2. A plurality of sealing elements (3) are introduced into the duct, the sealing elements having dimensions a, b and c in mutually orthogonal directions and the effective size SE of the sealing element being given by formula (2): SE=(a2+b2+c2)1/2. The sealing elements have an effective size SE, which is less than the effective size of the leak SL, so that sealing elements (3A) are drawn to the leak locality and caused, by reason of a pressure differential at that locality and attributable to the leak, to move over the leak and reduce the seepage.

Abstract: The present invention provides a dosage form for the treatment of bacterial, viral or fungal conditions which comprises, a pharmaceutically acceptable acidifying agent in an amount sufficient to reduce the pH at an environment of use to below pH4, and a pharmaceutically acceptable source of nitrite ions or a nitrate precursor therefor; wherein said acidifying agent and said source of nitrite ions or nitrate precursor are separately disposed in respective pharmaceutically acceptable carriers for admixture at the intended environment of use to release NO or NO2 ions.

Abstract: The present invention provides a dosage form for the treatment of bacterial, viral or fungal conditions which comprises, a pharmaceutically acceptable acidifying agent in an amount sufficient to reduce the pH at an environment of use to below pH4, and a pharmaceutically acceptable source of nitrite ions or a nitrate precursor therefor; wherein said acidifying agent and said source of nitrite ions or nitrate precursor are separately disposed in respective pharmaceutically acceptable carriers for admixture at the intended environment of use to release NO or NO2 ions. The invention also provides delivery systems for the topical medicament.

Abstract: The present invention provides a dosage form for the treatment of bacterial, viral or fungal conditions which comprises, a pharmaceutically acceptable acidifying agent in an amount sufficient to reduce the pH at an environment of use to below pH4, and a pharmaceutically acceptable source of nitrite ions or a nitrate precursor therefor; wherein said acidifying agent and said source of nitrite ions or nitrate precursor are separately disposed in respective pharmaceutically acceptable carriers for admixture at the intended environment of use to release NO or NO2 ions.

Abstract: A ground anchorage testing arrangement having an impulse imparting apparatus connectable to a ground anchorage tendon (20) or element thereof to be tested, the impulse imparting apparatus comprising an attachment means (22) for attachment to the ground anchorage tendon (20), a movable mass (31), a guide (28, 34) for guiding movement of the mass in the direction substantially aligned with the axis 0 of the ground anchorage to be tested and a drive means for imparting a driving force to move the mass in said direction (not shown). A method of assessing the integrity of ground anchorages, the method comprising the steps of (a) imparting a load impulse to a ground anchorage tendon to be tested, (b) monitoring the vibrational response signal of the anchorage to the imparted load impulse, (c) conditioning the vibrational response signal and (d) applying the conditioned vibrational response signal to an artificial neural network.

Abstract: The present invention relates to a method for evaluating biological effects in a substance which method comprises sampling the substance, subjecting the sample to an assay in the presence of a biosensor engineered with a gene which expresses a light emitting protein and noting the light output; characterized in that the biosensor is eukaryotic and the substance is assayable over any pH between pH1 and pH12. Such a eukaryotic sensor may be derived from Saccharomyces cerevisiae and is useful in assaying potable waters.

Abstract: The invention provides a process for protecting whole eukaryotes or parts thereof from an invasive attack from an invasive agent which comprises, selecting a prokaryotic bacterium which is capable of forming an L-form association with a host eukaryote and introducing an L-form bacteria into said host, wherein the bacteria is also selected to be antagonistic to the invasive agent. This process allows the protection of plants and plant parts against invasive organisms with which they have not already had contact.

Abstract: The present invention provides an immortalized insulin producing human &bgr;-cell which may be rendered glucose responsive by suitable bioengineering methods. The invention also provides a method for producing an immortalized glucose responsive insulin producing human &bgr;-cell comprising the steps of selecting an unregulated immortalized human insulin secreting &bgr;-cell, transecting said selected cell line with elements for the genetic control of glucose responsiveness and proliferating said transfected &bgr;-cell accordingly.

Abstract: The invention provides a ground sensing system (10) comprising: sensing means (19) located, in use, on a projectile being driven through ground by means of apparatus having a self adjustment between a vibration mode and a vibro-impact mode according to encountered ground resistance, the sensing means sensing the dynamic resistance of the ground that the projectile is passing through; signal processing means for processing the output of said sensing means to provide a dynamic resistance waveform (106); and waveform recognition means (108) for correlating said dynamic resistance waveform with stored dynamic waveforms for identifying a ground characteristic. The waveform recognition means may comprise a neural network system.

Abstract: An ophthalmoscope is disclosed comprising mirrors to generate a raster scan of laser light, and detect reflections of such light from the fundus of a patient's eye. The laser light originates from sources of at least three distinct wavelengths and is mixed to provide a single beam that, for each resolvable picture element of the raster scan, assumes in sequence each of the wavelengths. The reflected light is used to generate a multi-colored image of the fundus.

Abstract: A moling apparatus comprises a housing having a head for penetrating ground, an anvil in the housing connected to the head, and a hammer in the housing and spaced therefrom by a spring. A vibrator unit is spaced from the hammer and arranged to transfer vibration to the housing and the hammer. In a first mode of the apparatus, vibration transmitted to the housing causes fluidization of the surrounding ground to allow progressive penetration of the apparatus. In a second mode, the braking effect of the ground on the head causes the hammer to move against the spring and impact the anvil thereby driving the head through the ground, the apparatus being operable at or between each mode.