Patents Assigned to ABIC Ltd.
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Patent number: 6663872Abstract: The present invention relates to a DNA sequence comprising a nucleotide sequence encoding Hemorrhagic Enteritis virus. It is well known to the man of the art that determining the complete sequence of a virus enables the isolation and identification of the different genes contained therein, and their utilisation for different purposes such as for vaccination purposes, as potential vectors for gene delivery to be used in recombinant vaccination or for gene therapy. In addition, the sequence may be employed for diagnostic purposes wherein the disclosed sequence of any part thereof be used for the development of specific primers for Polymerase Chain Reaction processes (PCR) or as probes. The invention thus also concerns with HEV proteins encoded by the sequence of the invention or functional fragments thereof and to some of the uses of said sequences and proteins.Type: GrantFiled: November 20, 2000Date of Patent: December 16, 2003Assignee: ABIC Ltd.Inventors: Jacob Pitcovski, Margalit Mualem, Ziv Rei Koren, Simcha Krispel, Esther Shmueli, Yifat Peretz, Bezalel Gutter, Gilad Gallili, Amnon Michael, Doron Goldberg
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Patent number: 5804195Abstract: Invention relates to a vaccine for the prevention of Infectious Bursal Disease in poultry comprising an effective immunizing amount of a live attenuated intermediately-pathogenic IBD virus belonging to the strain deposited at the ECACC under No. V92052301 (MB), an effective immunizing amount of a live attenuated intermediately-pathogenic IBD virus belonging to the strain deposited at the ECACC under No. V92100106 (MB-2), or an effective immunizing amount of a live attenuated intermediately-pathogenic IBD virus belonging to the strain deposited at the ECACC under No. V92102209 (MB-1).Type: GrantFiled: November 30, 1993Date of Patent: September 8, 1998Assignee: ABIC Ltd.Inventor: Bezalel Gutter
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Patent number: 4792552Abstract: The present invention relates to an adduct of nicotinic acid with 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid (Norfloxacin) in particular in a ratio of 1:1. The invention relates also to pharmaceutical compositions and to aqeuous solutions comprising said adduct.Type: GrantFiled: September 11, 1987Date of Patent: December 20, 1988Assignee: Abic Ltd.Inventor: Haim Simonovitch
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Patent number: 4566995Abstract: The present invention relates to a process for the preparation of benzothiazepine derivatives of general formula I ##STR1## wherein R stands for hydrogen and acetyl or of acid addition salts thereof in which a corresponding compound of general formula II ##STR2## in which R has the same meaning as above is reacted with 2-(dimethylamino)-ethyl chloride in a biphasic system of water and a non-combustible aliphatic polychlorinated hydrocarbon solvent in the presence of calcium hydroxide or of barium hydroxide. The process is advantageously performed at a temperature between 15.degree. and the refluxing temperature of the aliphatic polychlorinated hydrocarbon solvent. The process is optionally performed in the presence of a suitable quaternary ammonium halide.Type: GrantFiled: April 1, 1985Date of Patent: January 28, 1986Assignee: ABIC Ltd.Inventors: Chaim Simonovitch, Theodor Hoffman, Sabar Sasson
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Patent number: 4515590Abstract: The present invention relates to an automatic injection apparatus for animals, in particular for chicks, which comprises a housing, a syringe with an injection needle giving the injection through an aperture on the front wall of said housing, a two-way air double action piston being connected to said syringe and to a source of air, activating means for said piston and means for connecting the syringe to a liquid container. Said apparatus has optionally additional parts, e.g. a timer fixing the length of the period of the injection; an air regulator; means for cleaning the air; counters measuring the numbers of animals being injected and/or pre-setting the number of animals to be injected; and a disinfecting device for the needle.Type: GrantFiled: February 3, 1983Date of Patent: May 7, 1985Assignee: Abic Ltd.Inventor: Nisim Daniel
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Patent number: 4470978Abstract: A composition is prepared of trimethoprim, an antibacterial sulfa drug or a pharmaceutically acceptable salt thereof, and phenoxyethanol in synergistically effective and antibacterial effective amounts thereof. Preferably the ratio of trimethoprim to sulfa drug to phenoxyethanol is between about 1:3-10:0.1-0.6.Type: GrantFiled: September 28, 1982Date of Patent: September 11, 1984Assignee: Abic Ltd.Inventor: Maurice E. Stolar
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Patent number: 4426522Abstract: The invention provides new hexahydro-1,2,4-triazine-3,5-dione derivatives having anticoccidiastatic activity, to the production thereof and to their use as part of a feed and/or pre-feed mixture.Type: GrantFiled: February 9, 1982Date of Patent: January 17, 1984Assignee: ABIC Ltd.Inventor: Chaim Simonovitch
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Patent number: 4402945Abstract: The invention provides new glycoside derivatives of 6-ethoxy-1,2-dihydro-2,2,4-trimethylquinoline, to the production thereof and to their use as biological antioxidants, to protect vitamin E-deficient animals and as growth promoting agents.Type: GrantFiled: May 6, 1981Date of Patent: September 6, 1983Assignee: Abic Ltd.Inventors: Emil Menachemoff, Oded Awerbuch, Raphael R. G. Haber
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Patent number: 4317824Abstract: The present invention deals with derivatives of quinoxaline-1,4-dioxides, processes for their preparation and their utility, inter alia, as pharmaceutical compositions for the treatment of infectious diseases as well as their use as antiseptic agents. Moreover said compounds show a good growth promoting effect in animals.Type: GrantFiled: June 13, 1977Date of Patent: March 2, 1982Assignee: Abic, Ltd.Inventor: Chaim Simonovitch
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Patent number: 4311711Abstract: Biocidal compositions are provided comprising a mixture of o-phenylphenol and 2,2'-methylene bis(4-chlorophenol). Said compositions advantageously include a surface active agent which is stable under basic conditions. There are also provided aqueous solutions comprising the above biocidal compositions.Type: GrantFiled: April 18, 1980Date of Patent: January 19, 1982Assignee: Abic Ltd.Inventor: Arye Doron
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Patent number: 4305932Abstract: The present invention deals with derivatives of 6-ethoxy-1,2,-dihydro-2,2,4-trimethylquinoline (called "Ethoxyquin"), processes for their preparation and their utility inter alia, as active ingredient of a pharmaceutical composition. Said compounds have, inter alia, under biological conditions anti-oxidant properties, may be used to protect Vitamin-E-deficient animals, and act as growth promoting agents.Type: GrantFiled: January 23, 1978Date of Patent: December 15, 1981Assignee: Abic Ltd.Inventors: Emil Menachemoff, Oded Awerbuch, Raphael R. G. Haber
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Patent number: 4212814Abstract: The present invention relates to a new process for the preparation of N.sup.1 -(2'-furanidyl)-5-fluoro-uracil, also called Ftorafur, which is a very important anti-cancer compound. Said process comprises reacting 2,3-dihydrofuran with water in the presence of a catalytic amount of an acidic catalyst at a pH below 2.5, removing excess of unreacted starting materials and reacting the mixture obtained with silylated-5-fluoro-uracil is in the presence of a Friedel Crafts type catalyst uracil in an inert organic solvent. The new process has many advantages in comparison with those used so far.Type: GrantFiled: April 30, 1979Date of Patent: July 15, 1980Assignee: Abic, Ltd.Inventors: Eva Schonberger, Zabar Sasson, Uri Michael
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Patent number: 4195087Abstract: The present invention deals with derivatives of naphthyridine, process for their preparation and their utility, inter alia, as anti-bacterides and as feed-additives.Type: GrantFiled: December 6, 1977Date of Patent: March 25, 1980Assignee: Abic, Ltd.Inventor: Chaim Simonovitch
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Patent number: 4174446Abstract: The present invention relates to a new process for the preparation of N.sup.1 -(2'-furanidyl)-5-fluoro-uracil, also called Ftorafur, which is a very important anti-cancer compound. Said process comprises reacting 2,3-dihydrofuran with water in the presence of a catalytic amount of an acidic catalyst at a pH below 2.5, removing excess of unreacted starting materials and reacting the mixture obtained with silylated-5-fluoro-uracil is in the presence of a Friedel Crafts type catalyst uracil in an inert organic solvent. The new process has many advantages in comparison with those used so far.Type: GrantFiled: October 11, 1977Date of Patent: November 13, 1979Assignee: ABIC Ltd.Inventors: Eva Schonberger, Zabar Sasson, Uri Michael
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Patent number: 4070469Abstract: Compositions for the treatment of bovine mastitis are provided. Said compositions comprise as active compound [2-carboxy-4-/2'-(5'-nitrofuryl)]quinoline N-oxide. The method is performed in such a manner that the composition is administered to the animal, preferably by way of intramamary infusion.Type: GrantFiled: June 28, 1976Date of Patent: January 24, 1978Assignee: Abic Ltd.Inventors: Raphael Ralph G. Haber, Eva Schoenberger, Morris E. Stolar
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Patent number: 4062940Abstract: There are disclosed water-soluble compositions comprising sulfadimidine sulfate, polyvinylpyrrolidine (PVP) and a physiologically acceptable water-soluble salt of pyrimethamine. Said compositions may comprise also a filler substance. There are also disclosed aqueous suspensions comprising the above composition and a method for the treatment of animals suffering from bacterial infections.Type: GrantFiled: April 8, 1977Date of Patent: December 13, 1977Assignee: Abic Ltd.Inventor: Morris E. Stolar
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Patent number: 4041160Abstract: There are disclosed water-suspendable compositions comprising a 1,3-bis-[(p-chlorobenzylidene)-amino]-guanidine (called Robenidine) or one of its salts. Said compositions comprise also N-methyl-2-pyrrolidone, a protective colloid water and, if required, a buffer yielding to the composition a pH of 7-9.5. Said composition may comprise additional substances, e.g., a potentiated or unpotentiated sulfa drug. There are also disclosed aqueous suspensions comprising the above composition and a method for the treatment of animals being infected with Cocciodiosis with said aqueous suspension.Type: GrantFiled: December 30, 1975Date of Patent: August 9, 1977Assignee: Abic Ltd.Inventor: Morris E. Stolar
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Patent number: 3978072Abstract: This invention relates to anti-inflammatory pyridone derivatives, particularly 2,6-dimethyl-1,4-dihydro-4-oxo-3,5 pyridine-dicarboxylates and derivatives thereof which have an anti-inflammatory action, as well as compositions therewith, use of these compounds for their anti-inflammatory effect, and production thereof. These 4-oxo pyridines of the present invention, refer to in the literature as 4-(1H)-pyridones are suitably prepared by reacting a 2,6-dimethyl-4-oxo 3,5 pyrone-dicarboxylate with an aniline in an acidic medium such as acetic acid.Type: GrantFiled: May 31, 1974Date of Patent: August 31, 1976Assignee: Abic Ltd.Inventors: Raphael Ralph G. Haber, Chaim Simonovitch
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Patent number: 3954996Abstract: There are disclosed water-soluble compositions comprising a 1,3-bis-[(p-chlorobenzylidene)-amino]-guanidine (called Robenidine) salt, particularly the hydrochloride. Said compositions comprise also a suitable water-soluble organic solvent and a suitable water-soluble solubilizer; the solvent and the solubilizer being miscible with each other. There are also disclosed aqueous solutions comprising the above composition and a method for the treatment of animals being infected with Cocciodiosis with said aqueous solution.Type: GrantFiled: July 15, 1974Date of Patent: May 4, 1976Assignee: ABIC Ltd.Inventors: Chaim Simonovitch, Morris E. Stolar