Patents Assigned to Abide Therapeutics, Inc.
  • Dual MAGL and FAAH inhibitors
    Patent number: 11129827
    Abstract: Provided herein are compounds and pharmaceutical compositions comprising said compounds useful as modulators of MAGL and/or FAAH. The subject compounds and compositions are useful for the treatment of pain and neurological disorders.
    Type: Grant
    Filed: June 4, 2019
    Date of Patent: September 28, 2021
    Assignee: Abide Therapeutics, Inc.
    Inventors: Cheryl A. Grice, Justin S. Cisar, Katharine K. Duncan, Yu Feng, John J. M. Wiener, Olivia D. Weber
  • Crystalline (R)-5-carbamoylpyridin-3-yl-2-methyl-4-(3-(trifluoromethoxy)benzyl)piperazine-1-carboxylate, compositions and methods of use thereof
    Patent number: 11053199
    Abstract: Provided herein are crystalline forms of (R)-5-carbamoylpyridin-3-yl-2-methyl-4-(3-(trifluoromethoxy)benzyl)piperazine-1-carboxylate. Pharmaceutical compositions comprising crystalline forms of (R)-5-carbamoylpyridin-3-yl-2-methyl-4-(3-(trifluoromethoxy)benzyl)piperazine-1-carboxylate are also disclosed.
    Type: Grant
    Filed: September 12, 2019
    Date of Patent: July 6, 2021
    Assignees: Celgene Corporation, Abide Therapeutics, Inc.
    Inventors: Lianfeng Huang, Nancy Tsou, Nicole Suzanne White, Jun Xu, Qun Zhang
  • SPIROCYCLE COMPOUNDS AND METHODS OF MAKING AND USING SAME
    Publication number: 20200022977
    Abstract: Provided herein are spirocycle compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL and/or ABHD6. Furthermore, the subject compounds and compositions are useful for the treatment of pain.
    Type: Application
    Filed: May 11, 2017
    Publication date: January 23, 2020
    Applicant: Abide Therapeutics, Inc.
    Inventors: Daniel J. BUZARD, Michael B. SHAGHAFI, Justin S. CISAR, Cheryl A. GRICE, Todd K. JONES, Olivia D. WEBER
  • Dual MAGL and FAAH inhibitors
    Patent number: 10350205
    Abstract: Provided herein are compounds and pharmaceutical compositions comprising said compounds useful as modulators of MAGL and/or FAAH. The subject compounds and compositions are useful for the treatment of pain and neurological disorders.
    Type: Grant
    Filed: March 12, 2018
    Date of Patent: July 16, 2019
    Assignee: Abide Therapeutics, Inc.
    Inventors: Cheryl A. Grice, Justin S. Cisar, Katharine K. Duncan, Yu Feng, John J. M. Wiener, Olivia D. Weber
  • Lp-PLA2 inhibitors
    Patent number: 10336709
    Abstract: Provided herein are lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitors, pharmaceutical compositions thereof, and methods of their use for the treatment of disease.
    Type: Grant
    Filed: September 29, 2016
    Date of Patent: July 2, 2019
    Assignee: ABIDE THERAPEUTICS, INC
    Inventors: Cheryl A. Grice, Micah Niphakis, Todd K. Jones
  • Pyrazole compounds and methods of making and using same
    Patent number: 10323038
    Abstract: Provided herein are pyrazole compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL and/or FAAH. Furthermore, the subject compounds and compositions are useful for the treatment of, for example, pain.
    Type: Grant
    Filed: November 18, 2016
    Date of Patent: June 18, 2019
    Assignee: ABIDE THERAPEUTICS, INC.
    Inventors: Cheryl A. Grice, Todd K. Jones, Katharine K. Duncan, Justin S. Cisar, Jeffrey E. Merit, Olivia D. Weber
  • Pyrazole MAGL inhibitors
    Patent number: 10266497
    Abstract: Provided herein are pyrazole compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of monoacylglycerol lipase (MAGL). Furthermore, the subject compounds and compositions are useful for the treatment of pain.
    Type: Grant
    Filed: May 22, 2018
    Date of Patent: April 23, 2019
    Assignee: ABIDE THERAPEUTICS, INC.
    Inventors: Cheryl A. Grice, John J. M. Wiener, Olivia D. Weber, Katharine K. Duncan
  • Pyrazole compounds and methods of making and using same
    Patent number: 10093630
    Abstract: Provided herein are pyrazole compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of one or more of MAGL, ABHD6, and FAAH. Furthermore, the subject compounds and compositions are useful for the treatment of, for example, pain, solid tumors and/or obesity.
    Type: Grant
    Filed: May 20, 2015
    Date of Patent: October 9, 2018
    Assignees: ABIDE THERAPEUTICS, INC., THE SCRIPPS RESEARCH INSTITUTE
    Inventors: Dale L. Boger, Katerina Otrubova, Justin S. Cisar, Cheryl A. Grice, Todd K. Jones
  • MAGL inhibitors
    Patent number: 10093635
    Abstract: Provided herein are piperazine carbamates and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL. Furthermore, the subject compounds and compositions are useful for the treatment of pain.
    Type: Grant
    Filed: November 15, 2017
    Date of Patent: October 9, 2018
    Assignee: ABIDE THERAPEUTICS, INC.
    Inventors: Cheryl A. Grice, Daniel J. Buzard, Michael B. Shaghafi
  • Spirocycle compounds and methods of making and using same
    Patent number: 10030020
    Abstract: Provided herein are spirocycle compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL and/or ABHD6. Furthermore, the subject compounds and compositions are useful for the treatment of pain.
    Type: Grant
    Filed: May 11, 2017
    Date of Patent: July 24, 2018
    Assignee: ABIDE THERAPEUTICS, INC.
    Inventors: Justin S. Cisar, Cheryl A. Grice, Todd K. Jones, Olivia D. Weber, Daniel J. Buzard, Michael B. Shaghafi
  • Piperazine carbamates and methods of making and using same
    Patent number: 9994537
    Abstract: Provided herein are piperazine carbamates and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL and/or ABHD6. Furthermore, the subject compounds and compositions are useful for the treatment of pain.
    Type: Grant
    Filed: August 8, 2017
    Date of Patent: June 12, 2018
    Assignee: ABIDE THERAPEUTICS, INC.
    Inventors: Justin S. Cisar, Cheryl A. Grice, Todd K. Jones, Olivia D. Weber, Dong-Hui Wang
  • N-hydroxy bicyclic hydantoin carbamates as tools for identification of serine hydrolase targets
    Patent number: 9981972
    Abstract: Provided herein are N-hydroxy bicyclic hydantoin carbamates and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of serine hydrolases. Furthermore, the subject compounds and compositions are useful for the treatment of one or more of cancer, pain, diabetes, obesity/metabolic syndrome, epilepsy, traumatic brain injury, and inflammation.
    Type: Grant
    Filed: May 20, 2015
    Date of Patent: May 29, 2018
    Assignees: ABIDE THERAPEUTICS, INC., THE SCRIPPS RESEARCH INSTITUTE
    Inventors: Benjamin F. Cravatt, Armand B. Cognetta, Jonathan J. Hulce, Micah J. Niphakis, Todd K. Jones, Cheryl A. Grice
  • MAGL inhibitors
    Patent number: 9981930
    Abstract: Provided herein are piperazine carbamates and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL. Furthermore, the subject compounds and compositions are useful for the treatment of pain.
    Type: Grant
    Filed: November 15, 2017
    Date of Patent: May 29, 2018
    Assignee: ABIDE THERAPEUTICS, INC.
    Inventors: Cheryl A. Grice, Donald L. Hertzog, Daniel J. Buzard, Nicole S. White
  • Carbamate compounds and methods of making and using same
    Patent number: 9957242
    Abstract: This disclosure provides compounds and compositions which may be modulators of MAGL and/or ABHD6 and their use as medicinal agents, processes for their preparation, and pharmaceutical compositions that include disclosed compounds as at least one active agent. The disclosure also provides for method of treating a patient in need thereof, where the patient is suffering from indications such as pain, solid tumor cancer and/or obesity comprising administering a disclosed compound or composition.
    Type: Grant
    Filed: September 21, 2016
    Date of Patent: May 1, 2018
    Assignees: THE SCRIPPS RESEARCH INSTITUTE, ABIDE THERAPEUTICS, INC.
    Inventors: Justin S. Cisar, Cheryl A. Grice, Todd K. Jones, Micah J. Niphakis, Jae Won Chang, Kenneth M Lum, Benjamin F. Cravatt
  • Pyrrolo-pyrrole carbamate and related organic compounds, pharmaceutical compositions, and medical uses thereof
    Patent number: 9828379
    Abstract: The invention provides pyrrolo-pyrrole carbamate and related organic compounds, compositions containing such compounds, medical kits, and methods for using such compounds and compositions to treat medical disorders, e.g., solid tumor cancer, obesity, Down's syndrome, Alzheimer's disease, or pain, in a patient. The octahydropyrrolo pyrrole carbamates could be derived from hexafluoroisopropanol, N,N-disuccinimide and such. The activity of carbamates in MAGL, FAAH, and ABHD6 assays are also described.
    Type: Grant
    Filed: July 1, 2014
    Date of Patent: November 28, 2017
    Assignee: ABIDE THERAPEUTICS, INC.
    Inventors: Todd K. Jones, Justin S. Cisar, Cheryl A. Grice, Dong-Hui Wang, Olivia D. Weber
  • Piperazine carbamates and methods of making and using same
    Patent number: 9771341
    Abstract: Provided herein are piperazine carbamates and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL and/or ABHD6. Furthermore, the subject compounds and compositions are useful for the treatment of pain.
    Type: Grant
    Filed: March 16, 2016
    Date of Patent: September 26, 2017
    Assignee: ABIDE THERAPEUTICS, INC.
    Inventors: Justin S. Cisar, Cheryl A. Grice, Todd K. Jones, Olivia D. Weber, Dong-Hui Wang
  • Carbamate compounds and of making and using same
    Patent number: 9567302
    Abstract: Provided herein are carbamate compounds which may be useful in the treatment of for example, pain, solid tumors and/or obesity.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: February 14, 2017
    Assignees: Abide Therapeutics, Inc., The Scripps Research Institute
    Inventors: Justin S. Cisar, Cheryl A. Grice, Todd K. Jones, Dong-Hui Wang, Olivia Weber, Benjamin F. Cravatt, Micah J. Niphakis, Armand Cognetta, Jae Won Chang
  • Carbamate compounds and of making and using same
    Patent number: 9133148
    Abstract: This disclosure provides piperazine carbamates and compositions which may be modulators of MAGL and/or ABHD6 and their use as medicinal agents, processes for their preparation, and pharmaceutical compositions that include disclosed piperazine carbamates as at least one active agent. The disclosure also provides for method of treating a patient in need thereof, where the patient is suffering from indications such as pain, solid tumor cancer and/or obesity comprising administering a disclosed compound or composition.
    Type: Grant
    Filed: January 16, 2015
    Date of Patent: September 15, 2015
    Assignees: The Scripps Research Institute, Abide Therapeutics, Inc.
    Inventors: Justin S. Cisar, Cheryl A. Grice, Todd K. Jones, Micah J. Niphakis, Jae Won Chang, Kenneth M. Lum, Benjamin F. Cravatt
  • CARBAMATE COMPOUNDS AND OF MAKING AND USING SAME
    Publication number: 20150080364
    Abstract: Provided herein are carbamate compounds which may be useful in the treatment of for example, pain, solid tumors and/or obesity.
    Type: Application
    Filed: March 15, 2013
    Publication date: March 19, 2015
    Applicants: Abide Therapeutics, Inc., The Scripps Research Insititute
    Inventors: Justin S. Cisar, Cheryl A. Grice, Todd K. Jones, Dong-Hui Wang, Olivia Weber, Benjamin F. Cravatt, Micah J. Niphakis, Armand Cognetta, Jae Won Chang