Abstract: The present disclosure provides isolated binding proteins such as humanized antibodies and antigen-binding fragments thereof that target alpha-synuclein, including multispecific isolated binding proteins that target both alpha-synuclein and insulin-like growth factor 1 receptor. Also provided are methods of using the binding proteins to treat alpha-synucleinopathies.
Type:
Application
Filed:
November 6, 2024
Publication date:
February 20, 2025
Applicant:
ABL BIO INCORPORATED
Inventors:
Sungwon AN, Dongin KIM, Jung-Won SHIN, Donghwan KIM, Hyesu YUN, Jinhyung AHN, Byungje SUNG, Yong-Gyu SON, Jinwon JUNG, Bora LEE, Daehae SONG, Youngdon PAK, Kyungjin PARK, Juhee KIM
Abstract: The present disclosure provides isolated binding proteins such as humanized antibodies and antigen-binding fragments thereof that target alpha-synuclein, including multispecific isolated binding proteins that target both alpha-synuclein and insulin-like growth factor 1 receptor. Also provided are methods of using the binding proteins to treat alpha-synucleinopathies.
Type:
Application
Filed:
May 12, 2022
Publication date:
December 1, 2022
Applicant:
ABL BIO INCORPORATED
Inventors:
Jinhyung AHN, Sungwon AN, Dongin KIM, Eunsil SUNG, Jaehyun EOM, Sang Hoon LEE, Seung-Jae LEE, Tae Kyung KIM, Min Sun CHOI, Weonkyoo YOU, Jaeho JUNG, Juhee KIM, Jinwon JUNG, Yeunju KIM, Yonggyu SON, Byungje SUNG