Abstract: A method of rapidly evaluating the susceptibility of a strain of bacteria to a cell wall synthesis inhibiting antibiotic based on an assessment of cell enlargement in response to doses of the cell wall synthesis inhibiting antibiotic which are correlated to breakpoints of bacterial susceptibility.
Type:
Application
Filed:
April 25, 2022
Publication date:
August 4, 2022
Applicant:
ABM TECHNOLOGIES, LLC
Inventors:
José Luis FERNÁNDEZ GARCÍA, Jaime GOSÁLVEZ BERENGUER, Rebeca SANTISO BRANDARIZ, Maria TAMAYO NOVAS, Germán BOU ARÉVALO
Abstract: A method of rapidly evaluating the susceptibility of a strain of bacteria to a cell wall synthesis inhibiting antibiotic based on an assessment of cell enlargement in response to doses of the cell wall synthesis inhibiting antibiotic which are correlated to breakpoints of bacterial susceptibility.
Type:
Grant
Filed:
July 2, 2014
Date of Patent:
May 3, 2022
Assignee:
ABM Technologies, LLC
Inventors:
Jose Luis Fernandez Garcia, Jaime Gosalvez Berenguer, Rebeca Santiso Brandariz, Maria Tamayo Novas, German Bou Arevalo
Abstract: The present invention relates to a method for the rapid evaluation of bacterial susceptibility or non-susceptibility of bacteria to antibiotics that inhibit protein synthesis. The rationale is to identify bacterial responses that depend or are influenced by protein synthesis. If this response is prevented or reduced by the antibiotic that inhibits the protein synthesis, the bacteria are susceptible to this antibiotic. Otherwise, if the response keeps similar despite the incubation with the antibiotic, the bacteria are not susceptible or resistant to this antibiotic. These responses could be determined at the DNA lev-el, cell wall level, morphological level or any other experimental approach, including metabolic, bio-chemical, physiological or genetic processes.
Type:
Grant
Filed:
January 19, 2016
Date of Patent:
November 12, 2019
Assignee:
ABM Technologies, LLC
Inventors:
José Luis Fernández García, Jaime Gosálvez Berenguer, Germán Bou Arévalo, Maria Tamayo Novas, Rebeca Santiso Brandariz, Fátima María Otero Fariña
Abstract: The present invention relates to am method for the rapid evaluation of bacterial susceptibility or non-susceptibility of bacteria to antibiotics that inhibit protein synthesis. The rationale is to identify bacterial responses that depend or are influenced by protein synthesis. If this response is prevented or reduced by the antibiotic that inhibits the protein synthesis, the bacteria are susceptible to this antibiotic. Otherwise, if the response keeps similar despite the incubation with the antibiotic, the bacteria are no susceptible or resistant to this antibiotic.
Type:
Application
Filed:
January 19, 2016
Publication date:
July 21, 2016
Applicant:
ABM TECHNOLOGIES, LLC
Inventors:
José Luis FERNÁNDEZ GARCÍA, Jaime GOSÁLVEZ BERENGUER, Germán BOU ARÉVALO, Maria TAMAYO NOVAS, Rebeca SANTISO BRANDARIZ, Fátima María OTERO FARIÑA
Abstract: A method of rapidly evaluating the susceptibility of a strain of bacteria to a cell wall synthesis inhibiting antibiotic based on an assessment of cell enlargement in response to doses of the cell wall synthesis inhibiting antibiotic which are correlated to breakpoints of bacterial susceptibility.
Type:
Application
Filed:
July 2, 2014
Publication date:
January 8, 2015
Applicant:
ABM TECHNOLOGIES, LLC
Inventors:
Jose Luis Fernandez Garcia, Jaime Gosalvez Berenguer, Rebeca Santiso Brandariz, Maria Tamayo Novas, German Bou Arevalo