Patents Assigned to Abraxis BioScience
  • Combinations and modes of administration of therapeutic agents and combination therapy
    Patent number: 8034375
    Abstract: The present invention provides combination therapy methods of treating proliferative diseases (such as cancer) comprising a first therapy comprising administering to an individual an effective amount of a taxane in a nanoparticle composition, and a second therapy which may include, for example, radiation, surgery, administration of chemotherapeutic agents, or combinations thereof. Also provided are methods of administering to an individual a drug taxane in a nanoparticle composition based on a metronomic dosing regime.
    Type: Grant
    Filed: February 21, 2006
    Date of Patent: October 11, 2011
    Assignee: Abraxis Bioscience, LLC
    Inventors: Neil P. Desai, Patrick Soon-Shiong
  • Compositions and methods for preparation of poorly water soluble drugs with increased stability
    Patent number: 8034765
    Abstract: The present invention provides stable pharmaceutical compositions of poorly water soluble pharmaceutical agents and stabilizing agents which function to increase stability of the compositions. The use of stabilizing agents provide extended stability of nanoparticle suspensions and other formulations of poorly water soluble pharmaceutical agents such as docetaxel under certain conditions, for example upon dilution for administration.
    Type: Grant
    Filed: August 30, 2006
    Date of Patent: October 11, 2011
    Assignee: Abraxis BioScience, LLC
    Inventors: Tapas De, Neil P. Desai, Andrew Yang, Zachary Yim, Patrick Soon-Shiong
  • Compositions, methods of use and preparation of 2,6-diisopropyl phenol and analogs for ischemic injury
    Patent number: 8026275
    Abstract: The present invention provides novel 2,6-diisopropyl phenol2,6-diisopropyl phenol analogs and sterile, stable pharmaceutical compositions of 2,6-diisopropyl phenol 2,6-diisopropyl phenol and analogs thereof useful as an antioxidant in the treatment of ischemic injury including stroke and other cerebral injury. 2,6-diisopropyl phenol or its analogs are administered in a dosage effective to produce blood levels and brain levels of the drug that can prevent free radical damage associated with ischemic injury.
    Type: Grant
    Filed: February 17, 2006
    Date of Patent: September 27, 2011
    Assignee: Abraxis BioScience, LLC
    Inventors: Neil P. Desai, Chunlin Tao, Cheng Zhi Yu, Vuong Trieu, Patrick Soon-Shiong
  • COMPOSITIONS AND METHODS FOR PREPARATION OF POORLY WATER SOLUBLE DRUGS WITH INCREASED STABILITY
    Publication number: 20110196026
    Abstract: The present invention provides stable pharmaceutical compositions of poorly water soluble pharmaceutical agents and stabilizing agents which function to increase stability of the compositions. The use of stabilizing agents provide extended stability of nanoparticle suspensions and other formulations of poorly water soluble pharmaceutical agents such as docetaxel under certain conditions, for example upon dilution for administration.
    Type: Application
    Filed: September 2, 2010
    Publication date: August 11, 2011
    Applicant: Abraxis BioScience, Inc.
    Inventors: Tapas De, Neil P. Desai, Andrew Yang, Zachary Yim, Patrick Soon-Shiong
  • Compositions and methods for preparation of poorly water soluble drugs with increased stability
    Patent number: 7981445
    Abstract: The present invention provides stable pharmaceutical compositions of poorly water soluble pharmaceutical agents and stabilizing agents which function to increase stability of the compositions. The use of stabilizing agents provide extended stability of nanoparticle suspensions and other formulations of poorly water soluble pharmaceutical agents such as docetaxel under certain conditions, for example upon dilution for administration.
    Type: Grant
    Filed: March 11, 2009
    Date of Patent: July 19, 2011
    Assignee: Abraxis Bioscience, LLC
    Inventors: Tapas De, Neil P. Desai, Andrew Yang, Zachary Yim, Patrick Soon-Shiong
  • TRIAZINE DERIVATIVES AND THEIR THERAPEUTICAL APPLICATIONS
    Publication number: 20110150763
    Abstract: The invention provides for Triazine derivatives and their use to modulate protein kinase activity in a variety of conditions and diseases.
    Type: Application
    Filed: December 17, 2010
    Publication date: June 23, 2011
    Applicant: ABRAXIS BIOSCIENCE, LLC
    Inventors: Chunlin Tao, Qinwei Wang, Neil P. Desai, Patrick Soon-Shiong
  • Compositions and methods of delivery of pharmacological agents
    Patent number: 7923536
    Abstract: The present invention relates to a pharmaceutical composition comprising a pharmaceutical agent and a pharmaceutically acceptable carrier, which carrier comprises a protein, for example, human serum albumin and/or deferoxamine. The human serum albumin is present in an amount effective to reduce one or more side effects associated with administration of the pharmaceutical composition. The invention also provides methods for reducing one or more side effects of administration of the pharmaceutical composition, methods for inhibiting microbial growth and oxidation in the pharmaceutical composition, and methods for enhancing transport and binding of a pharmaceutical agent to a cell.
    Type: Grant
    Filed: April 12, 2010
    Date of Patent: April 12, 2011
    Assignee: Abraxis BioScience, LLC
    Inventors: Neil P. Desai, Patrick Soon-Shiong, Vuong Trieu
  • LENS ARRAYS AND METHODS OF MAKING THE SAME
    Publication number: 20110076456
    Abstract: In general, in a first aspect, the invention features a method that includes depositing a first material on a surface of an article to form a layer including the first material. The surface of the article includes a plurality of protrusions and the layer including the first material forms a plurality of lenses. Each lens corresponds to a protrusion on the substrate surface.
    Type: Application
    Filed: August 5, 2010
    Publication date: March 31, 2011
    Applicant: Abraxis Bioscience LLC
    Inventor: Jian Jim Wang
  • Q3 SPARC DELETION MUTANT AND USES THEREOF
    Publication number: 20110009337
    Abstract: The invention provides for SPARC polypeptides with a mutation corresponding to a deletion of the third glutamine in the mature fault of the human SPARC protein, nucleic acids encoding such polypeptides, antibodies against such polypeptides, and methods of the use of such polypeptides, nucleic acids, and antibodies.
    Type: Application
    Filed: September 10, 2010
    Publication date: January 13, 2011
    Applicant: Abraxis BioScience, LLC
    Inventors: Vuong Trieu, Neil P. Desai, Patrick Soon-Shiong
  • Triazine derivatives and their therapeutical applications
    Patent number: 7858782
    Abstract: The invention provides for Triazine derivatives and their use to modulate protein kinase activity in a variety of conditions and diseases.
    Type: Grant
    Filed: December 14, 2007
    Date of Patent: December 28, 2010
    Assignee: Abraxis BioScience, LLC
    Inventors: Chunlin Tao, Qinwei Wang, Neil P. Desai, Patrick Soon-Shiong
  • USE OF 2 ANTI-SPARC ANTIBODIES TO PREDICT RESPONSE TO CHEMOTHERAPY
    Publication number: 20100310507
    Abstract: The invention provides anti-SPARC antibody-based techniques for predicting a response to chemotherapy.
    Type: Application
    Filed: May 28, 2010
    Publication date: December 9, 2010
    Applicant: Abraxis BioScience, LLC
    Inventors: Vuong Trieu, Neil Desai, Daniel Knauer
  • DI-ESTER PRODRUGS OF CAMPTOTHECIN, PROCESS FOR THEIR PREPARATION AND THEIR THERAPEUTICAL APPLICATIONS
    Publication number: 20100305148
    Abstract: The present invention is related to 10,20-di-O ester derivatives of camptothecin and pharmaceutical formulations thereof. The compounds and pharmaceutical formulations of the present invention possess increased biological life span and bioavailability and reduced toxicity, while maintaining anti-cancer activity.
    Type: Application
    Filed: April 13, 2010
    Publication date: December 2, 2010
    Applicant: Abraxis BioScience, LLC
    Inventors: Patrick Soon-Shiong, Neil P. Desai, Chunlin Tao, Cheng Zhi Yu
  • DICARBONYL DERIVATIVES AND METHODS OF USE
    Publication number: 20100279963
    Abstract: Derivatives of dicarbonyl compounds having antitumor and antibiotic activity which can be used as anticancer agents.
    Type: Application
    Filed: July 1, 2010
    Publication date: November 4, 2010
    Applicant: Abraxis BioScience, LLC
    Inventors: Chunlin Tao, Qinwei Wang, Vuong Trieu, Neil Desai, Patrick Soon-Shiong
  • Compositions and methods of delivery of pharmacological agents
    Patent number: 7820788
    Abstract: The present invention relates to a pharmaceutical composition comprising a pharmaceutical agent and a pharmaceutically acceptable carrier, which carrier comprises a protein, for example, human serum albumin and/or deferoxamine. The human serum albumin is present in an amount effective to reduce one or more side effects associated with administration of the pharmaceutical composition. The invention also provides methods for reducing one or more side effects of administration of the pharmaceutical composition, methods for inhibiting microbial growth and oxidation in the pharmaceutical composition, and methods for enhancing transport and binding of a pharmaceutical agent to a cell.
    Type: Grant
    Filed: October 26, 2006
    Date of Patent: October 26, 2010
    Assignee: Abraxis Bioscience, LLC
    Inventors: Neil P. Desai, Patrick Soon-Shiong, Vuong Trieu
  • Analogs of ansamycin and pharmaceutical compositions thereof
    Patent number: 7816346
    Abstract: Analogs of geldanamycin (an ansamycin), pharmaceutical formulations comprising such analogs, and methods of use (e.g., treating tumors).
    Type: Grant
    Filed: November 15, 2007
    Date of Patent: October 19, 2010
    Assignee: Abraxis BioScience, LLC
    Inventors: Chunlin Tao, Hongna Han, Xiaowen Sun, Neil Desai, Patrick Soon-Shiong
  • Dicarbonyl derivatives and methods of use
    Patent number: 7799954
    Abstract: Derivatives of dicarbonyl compounds having antitumor and antibiotic activity which can be used as anticancer agents.
    Type: Grant
    Filed: November 14, 2007
    Date of Patent: September 21, 2010
    Assignee: Abraxis BioScience, LLC
    Inventors: Chunlin Tao, Qinwei Wang, Vuong Trieu, Neil Desai, Patrick Soon-Shiong
  • COMPOSITIONS AND METHODS OF DELIVERY OF PHARMACOLOGICAL AGENTS
    Publication number: 20100226996
    Abstract: The present invention relates to a pharmaceutical composition comprising a pharmaceutical agent and a pharmaceutically acceptable carrier, which carrier comprises a protein, for example, human serum albumin and/or deferoxamine. The human serum albumin is present in an amount effective to reduce one or more side effects associated with administration of the pharmaceutical composition. The invention also provides methods for reducing one or more side effects of administration of the pharmaceutical composition, methods for inhibiting microbial growth and oxidation in the pharmaceutical composition, and methods for enhancing transport and binding of a pharmaceutical agent to a cell.
    Type: Application
    Filed: October 26, 2006
    Publication date: September 9, 2010
    Applicant: Abraxis BioScience, Inc.
    Inventors: Neil P. Desai, Patrick Soon-Shiong, Vuong Trieu
  • Methods and compositions for treating proliferative diseases
    Patent number: 7780984
    Abstract: The present invention provides combination therapy methods of treating proliferative diseases (such as cancer) comprising a first therapy comprising administering to an individual an effective amount of a taxane in a nanoparticle composition, and a second therapy which may include, for example, radiation, surgery, administration of chemotherapeutic agents, or combinations thereof. Also provided are methods of administering to an individual a drug taxane in a nanoparticle composition based on a metronomic dosing regime.
    Type: Grant
    Filed: July 20, 2007
    Date of Patent: August 24, 2010
    Assignee: Abraxis Bioscience, LLC
    Inventors: Neil P. Desai, Patrick Soon-Shiong, Tapas K. De
  • Compositions comprising poorly water soluble pharmaceutical agents and antimicrobial agents
    Patent number: 7771751
    Abstract: The present invention provides compositions comprising a poorly water soluble pharmaceutical agent, a carrier protein, and an antimicrobial agent, wherein significant microbial growth is inhibited in the composition. The amount of the antimicrobial agent in the composition may be below the level that induces a toxicological effect or at a level where a potential side effect can be controlled or tolerated. Also provided are compositions comprising a poorly water soluble pharmaceutical agent, a carrier protein, a sugar, and optionally an antimicrobial agent. Methods of using the compositions are also provided.
    Type: Grant
    Filed: August 30, 2006
    Date of Patent: August 10, 2010
    Assignee: Abraxis Bioscience, LLC
    Inventors: Neil P. Desai, Raj Selvaraj, Andrew Yang, Patrick Soon-Shiong
  • Combinations and modes of administration of therapeutic agents and combination therapy
    Patent number: 7758891
    Abstract: The present invention provides combination therapy methods of treating proliferative diseases (such as cancer) comprising a first therapy comprising administering to an individual an effective amount of a taxane in a nanoparticle composition, and a second therapy which may include, for example, radiation, surgery, administration of chemotherapeutic agents, or combinations thereof. Also provided are methods of administering to an individual a drug taxane in a nanoparticle composition based on a metronomic dosing regime.
    Type: Grant
    Filed: December 12, 2008
    Date of Patent: July 20, 2010
    Assignee: Abraxis Bioscience, LLC
    Inventors: Neil P. Desai, Patrick Soon-Shiong