Abstract: This invention relates to matrix patches for the topical (i.e., transdermal) delivery of piroxicam and methods for the treatment of acute and chronic pain and inflammation therewith, particularly pain and inflammation caused by sports injuries or other muscle aches or injuries requiring the application of analgesic and/or anti-inflammation medication, in this instance, piroxicam.

Abstract: The present invention provides a fullerene suspension and a method for producing a fullerene suspension having high dispersion stability without any chemical compound. Also, the fullerene suspension and its producing method makes it possible to be applied in various fields including the field of medical and pharmaceutical science and the field of foods and environment, in which the fullerene suspension obtained by the prior methods had not been applied. The fullerene is ground to form nanoparticles by irradiating a fullerene in a poor solvent with a laser. The pulse laser having a width of several-ten femtoseconds to several-hundred nanoseconds is appropriately applied.

Abstract: This invention relates to topical pharmaceutical preparations and methods for the treatment of acute and chronic pain and inflammation therewith. The preparations have a saturated solution of an active pharmaceutical ingredient in a solvent therefor in intimate combination and contact with a suspension of nanoparticles of the active pharmaceutical ingredient in the solvent, and a pharmaceutically acceptable carrier therefor, and are administered topically.

Abstract: A method of producing a medicinal nanoparticle suspension is provided, wherein a medicinal ingredient added in a suspending solution is ground to form nanoparticles of the medicinal ingredient by irradiating the suspending solution with a laser. The process is implemented after adding a poorly water-soluble or water-insoluble medicinal ingredient of a drug in a poor solvent to form the suspending solution.