Abstract: Disclosed herein are devices for assessing drug dissolution, absorption and permeation, the devices comprising a chamber, a permeability barrier, and a securing cap, each in fluid communication with each other. The chamber comprises a reservoir and an extension. The permeability barrier is configured to hold cells, tissues, or artificial membranes, and the securing cap is configured to reversibly attach to the permeability barrier or the extension of the chamber. Also provided are systems for assessing drug dissolution, absorption and permeation, the systems comprising at least one of the devices for assessing drug dissolution, absorption and permeation, a dissolution vessel configured to hold a dissolution medium, and a stirring apparatus within the dissolution vessel. Methods for concomitant measuring of dissolution, absorption and/or permeation of a drug are also provided.

Abstract: Nucleic acids and vectors for interfering with the expression of membrane efflux transport proteins in cells that express such proteins are provided. Also provided are cells and cell lines comprising such nucleic acids and vectors. Methods for screening chemicals and biomolecules for gastrointestinal absorption in animals, and kits for practicing such methods are also provided.

Abstract: Nucleic acids and vectors for interfering with the expression of membrane efflux transport proteins in cells that express such proteins are provided. Also provided are cells and cell lines comprising such nucleic acids and vectors. Methods for screening chemicals and biomolecules for gastrointestinal absorption in animals, and kits for practicing such methods are also provided.

Abstract: Nucleic acids and vectors for interfering with the expression of membrane efflux transport proteins in cells that express such proteins are provided. Also provided are cells and cell lines comprising such nucleic acids and vectors. Methods for screening chemicals and biomolecules for gastrointestinal absorption in animals, and kits for practicing such methods are also provided.

Abstract: Nucleic acids and vectors for interfering with the expression of membrane efflux transport proteins in cells that express such proteins are provided. Also provided are cells and cell lines comprising such nucleic acids and vectors. Methods for screening chemicals and biomolecules for gastrointestinal absorption in animals, and kits for practicing such methods are also provided.

Abstract: Nucleic acids and vectors for interfering with the expression of membrane efflux transport proteins in cells that express such proteins are provided. Also provided are cells and cell lines comprising such nucleic acids and vectors. Methods for screening chemicals and biomolecules for gastrointestinal absorption in animals, and kits for practicing such methods are also provided.

Abstract: Nucleic acids and vectors for interfering with the expression of membrane efflux transport proteins in cells that express such proteins are provided. Also provided are cells and cell lines comprising such nucleic acids and vectors. Methods for screening chemicals and biomolecules for gastrointestinal absorption in animals, and kits for practicing such methods are also provided.