Abstract: Nucleic acids and vectors for interfering with the expression of membrane efflux transport proteins in cells that express such proteins are provided. Also provided are cells and cell lines comprising such nucleic acids and vectors. Methods for screening chemicals and biomolecules for gastrointestinal absorption in animals, and kits for practicing such methods are also provided.
Type:
Application
Filed:
November 9, 2007
Publication date:
May 29, 2008
Applicant:
Absorption Systems LP
Inventors:
Albert J. Owen, Ismael J. Hidalgo, Jibin Li, Wei Zhang