Abstract: Provided herein are settable and non-settable compositions for use in surgical procedures comprising a variety of disclosed particles and optionally including previously unclotted, lyophilized, optionally crosslinked mammalian blood plasma. Also provided are related compositions, including surgical kits and packages, as well as methods of making and using the compositions.
Type:
Grant
Filed:
April 26, 2023
Date of Patent:
May 13, 2025
Assignee:
Abyrx, Inc.
Inventors:
Richard Kronenthal, John Pacifico, Aniq Darr
Abstract: Provided herein are bone hemostatic and adhesive compositions for use in surgical procedures comprising a variety of disclosed particles. Also provided are related compositions, including surgical hardware, surgical kits and packages, as well as methods of making and using the compositions.
Type:
Grant
Filed:
January 31, 2022
Date of Patent:
April 22, 2025
Assignee:
Abyrx, Inc.
Inventors:
John Pacifico, Aniq Darr, Richard L. Kronenthal
Abstract: The present disclosure provides methods of stabilizing surgical screws comprising the intraoperative mixing of reactive putties to yield a homogenous putty composition (HPC) into which the screw is inserted, wherein the HPC comprises a polyurethane or polyurethane urea copolymer, one or more particulate materials, and one or more additive materials.
Type:
Grant
Filed:
August 6, 2021
Date of Patent:
July 30, 2024
Assignee:
Abyrx, Inc.
Inventors:
Richard L. Kronenthal, Aniq Darr, John Pacifico
Abstract: Provided herein are settable and non-settable compositions for use in surgical procedures comprising a variety of disclosed particles and optionally including previously unclotted, lyophilized, optionally crosslinked mammalian blood plasma. Also provided are related compositions, including surgical kits and packages, as well as methods of making and using the compositions.
Type:
Grant
Filed:
May 30, 2018
Date of Patent:
June 13, 2023
Assignee:
Abyrx, Inc.
Inventors:
Richard Kronenthal, John Pacifico, Aniq Darr
Abstract: The present invention relates to water soluble and completely absorbable and/or physiologically degradable hemostatic compositions having a wax or wax-like base effective for tamponade hemostasis of bone or cartilage.
Type:
Grant
Filed:
October 30, 2019
Date of Patent:
May 9, 2023
Assignee:
Abyrx, Inc.
Inventors:
David Knaack, John Pacifico, Marci Wirtz, Richard L. Kronenthal, Frank Do, Aniq Darr
Abstract: The present invention relates to settable compositions for use in surgery. The invention also provides related compositions, including surgical kits and packages, as well as methods of making and using the settable compositions.
Type:
Grant
Filed:
October 30, 2019
Date of Patent:
August 30, 2022
Assignee:
Abyrx, Inc.
Inventors:
John Pacifico, Aniq Darr, Richard L. Kronenthal
Abstract: Provided herein are bio-absorbable, settable and homogenous multi-putty bone-adhesive compositions for medical use in tissue hemostasis, surgical repair and reconstruction. Also provided are improved methods of intraoperative use of said compositions for re-approximation of adjacent bone fragments to create a restored alignment and stabilize fracture line.
Type:
Grant
Filed:
November 7, 2018
Date of Patent:
November 2, 2021
Assignee:
Abyrx, Inc.
Inventors:
Richard L. Kronenthal, Aniq Darr, John Pacifico
Abstract: The disclosure relates to polyurethane and polyureaurethane based putty compositions which harden into a fully cured solid form at room temperature and body temperature and are suitable for use as a bone cement, bone substitute, hard tissue adhesive, or bone hemostatic agent.
Type:
Grant
Filed:
October 29, 2019
Date of Patent:
September 14, 2021
Assignee:
Abyrx, Inc.
Inventors:
Rao Bezwada, Aniq Darr, Richard L. Kronenthal, John Pacifico
Abstract: The invention relates to a device comprising a surgical material and a support material and related methods for the application of the surgical material to a wound or surgical site using the device.
Type:
Grant
Filed:
October 19, 2018
Date of Patent:
August 25, 2020
Assignee:
Abyrx, Inc.
Inventors:
John Pacifico, Frank Do, Richard L. Kronenthal, Aniq Darr
Abstract: The present invention relates to water soluble and completely absorbable and/or physiologically degradable hemostatic compositions having a wax or wax-like base effective for tamponade hemostasis of bone or cartilage.
Type:
Grant
Filed:
August 7, 2018
Date of Patent:
February 4, 2020
Assignee:
Abyrx, Inc.
Inventors:
David Knaack, John Pacifico, Marci Wirtz, Richard L. Kronenthal, Frank Do, Aniq Darr
Abstract: The disclosure relates to polyurethane and polyureaurethane based putty compositions which harden into a fully cured solid form at room temperature and body temperature and are suitable for use as a bone cement, bone substitute, hard tissue adhesive, or bone hemostatic agent.
Type:
Grant
Filed:
July 17, 2018
Date of Patent:
January 7, 2020
Assignee:
Abyrx, Inc.
Inventors:
Rao Bezwada, Aniq Darr, Richard L. Kronenthal, John Pacifico
Abstract: The present invention relates to settable compositions for use in surgery. The invention also provides related compositions, including surgical kits and packages, as well as methods of making and using the settable compositions.
Type:
Grant
Filed:
August 10, 2017
Date of Patent:
December 31, 2019
Assignee:
Abyrx, Inc.
Inventors:
John Pacifico, Aniq Darr, Richard L. Kronenthal
Abstract: The present invention relates to water soluble and completely absorbable and/or physiologically degradable hemostatic compositions having a wax or wax-like base effective for tamponade hemostasis of bone or cartilage.
Type:
Grant
Filed:
August 7, 2018
Date of Patent:
December 31, 2019
Assignee:
Abyrx, Inc.
Inventors:
David Knaack, John Pacifico, Marci Wirtz, Richard L. Kronenthal, Frank Do, Aniq Darr
Abstract: The invention relates to a device comprising a surgical material and a support material and related methods for the application of the surgical material to a wound or surgical site using the device.
Type:
Grant
Filed:
September 10, 2015
Date of Patent:
February 12, 2019
Assignee:
Abyrx, Inc.
Inventors:
John Pacifico, Frank Do, Richard L. Kronenthal, Aniq Darr
Abstract: The disclosure relates to polyurethane and polyureaurethane based putty compositions which harden into a fully cured solid form at room temperature and body temperature and are suitable for use as a bone cement, bone substitute, hard tissue adhesive, or bone hemostatic agent.
Type:
Grant
Filed:
March 18, 2016
Date of Patent:
August 14, 2018
Assignee:
Abyrx, Inc.
Inventors:
Rao Bezwada, Aniq Darr, Richard L. Kronenthal, John Pacifico
Abstract: A device is described that can accept two or more components for mixing and preparing a composition within the device. Once mixed and prepared, the device can deliver the composition to a surgical site. The composition can be a putty-like material that sets over time at the surgical site, such as a hemostatic device or a device for sealing a hole or cavity in bone.
Abstract: Described herein are applicators for delivery of a viscous material to a bone surface and methods of use. The applicator includes an elongate handle portion and a tip coupled to a distal location of the handle portion and formed of an elastomeric material configured to conform to the bone surface. The tip includes a bend a distance away from the distal location, a contact surface distal to the bend and including one or more surface features configured to adhere to the viscous material, and a front end having a conic curvature. The bend is between about 20 degrees to about 40 degrees from a longitudinal axis of the tip.
Type:
Grant
Filed:
June 7, 2012
Date of Patent:
January 30, 2018
Assignee:
Abyrx Inc.
Inventors:
Jeffrey Kapec, Kazuna Tanaka, Yukiko Naoi, Marci Wirtz
Abstract: The present invention relates to settable compositions for use in surgery. The invention also provides related compositions, including surgical kits and packages, as well as methods of making and using the settable compositions.
Type:
Grant
Filed:
November 25, 2014
Date of Patent:
November 28, 2017
Assignee:
Abyrx Inc.
Inventors:
John Pacifico, Aniq Darr, Richard L. Kronenthal
Abstract: The present invention relates to absorbable polyurethane compositions suitable for use in bone repair or reconstruction. The present invention relates to the field of polyurethane-based cements, and putties for use in bone hemostasis, repair and reconstruction. The putty compositions may comprise a mixture of two or more individual putties formed through mixing of one or more reactive components and one or more additive (filler) components. Also disclosed herein are methods of using the putty compositions in medical applications to repair gaps or fractures, or to aid in tissue growth or adhesion.
Type:
Grant
Filed:
September 5, 2012
Date of Patent:
April 19, 2016
Assignee:
Abyrx Inc.
Inventors:
Rao Bezwada, Aniq Darr, Richard L. Kronenthal, John Pacifico
Abstract: A bone adhesive application device has a pliable structure with an application surface upon which a bone adhesive may be applied. The application surface has a surface energy substantially equal to or less than a surface energy of the bone adhesive to reduce adhesion between the bone adhesive and the bone adhesive application device. The bone adhesive application device may be included in a kit for repairing bone defects having a bone adhesive formed from a reactive biocompatible polyurethane material. The bone adhesive may be applied to a bone defect by positioning the pliable structure over at least a portion of the bone defect, delivering the bone adhesive to the bone defect and removing the pliable structure from the bone adhesive.
Type:
Grant
Filed:
August 6, 2010
Date of Patent:
October 7, 2014
Assignee:
ABYRX, Inc.
Inventors:
Richard J. Deslauriers, Steven Joseph Beer, Eric Kolb, Joseph Jannetty