Patents Assigned to ABYRX, Inc.
  • Patent number: 10751036
    Abstract: The invention relates to a device comprising a surgical material and a support material and related methods for the application of the surgical material to a wound or surgical site using the device.
    Type: Grant
    Filed: October 19, 2018
    Date of Patent: August 25, 2020
    Assignee: Abyrx, Inc.
    Inventors: John Pacifico, Frank Do, Richard L. Kronenthal, Aniq Darr
  • Patent number: 10549009
    Abstract: The present invention relates to water soluble and completely absorbable and/or physiologically degradable hemostatic compositions having a wax or wax-like base effective for tamponade hemostasis of bone or cartilage.
    Type: Grant
    Filed: August 7, 2018
    Date of Patent: February 4, 2020
    Assignee: Abyrx, Inc.
    Inventors: David Knaack, John Pacifico, Marci Wirtz, Richard L. Kronenthal, Frank Do, Aniq Darr
  • Patent number: 10525160
    Abstract: The disclosure relates to polyurethane and polyureaurethane based putty compositions which harden into a fully cured solid form at room temperature and body temperature and are suitable for use as a bone cement, bone substitute, hard tissue adhesive, or bone hemostatic agent.
    Type: Grant
    Filed: July 17, 2018
    Date of Patent: January 7, 2020
    Assignee: Abyrx, Inc.
    Inventors: Rao Bezwada, Aniq Darr, Richard L. Kronenthal, John Pacifico
  • Patent number: 10517998
    Abstract: The present invention relates to settable compositions for use in surgery. The invention also provides related compositions, including surgical kits and packages, as well as methods of making and using the settable compositions.
    Type: Grant
    Filed: August 10, 2017
    Date of Patent: December 31, 2019
    Assignee: Abyrx, Inc.
    Inventors: John Pacifico, Aniq Darr, Richard L. Kronenthal
  • Patent number: 10517985
    Abstract: The present invention relates to water soluble and completely absorbable and/or physiologically degradable hemostatic compositions having a wax or wax-like base effective for tamponade hemostasis of bone or cartilage.
    Type: Grant
    Filed: August 7, 2018
    Date of Patent: December 31, 2019
    Assignee: Abyrx, Inc.
    Inventors: David Knaack, John Pacifico, Marci Wirtz, Richard L. Kronenthal, Frank Do, Aniq Darr
  • Patent number: 10201338
    Abstract: The invention relates to a device comprising a surgical material and a support material and related methods for the application of the surgical material to a wound or surgical site using the device.
    Type: Grant
    Filed: September 10, 2015
    Date of Patent: February 12, 2019
    Assignee: Abyrx, Inc.
    Inventors: John Pacifico, Frank Do, Richard L. Kronenthal, Aniq Darr
  • Patent number: 10046083
    Abstract: The disclosure relates to polyurethane and polyureaurethane based putty compositions which harden into a fully cured solid form at room temperature and body temperature and are suitable for use as a bone cement, bone substitute, hard tissue adhesive, or bone hemostatic agent.
    Type: Grant
    Filed: March 18, 2016
    Date of Patent: August 14, 2018
    Assignee: Abyrx, Inc.
    Inventors: Rao Bezwada, Aniq Darr, Richard L. Kronenthal, John Pacifico
  • Patent number: 9931468
    Abstract: A device is described that can accept two or more components for mixing and preparing a composition within the device. Once mixed and prepared, the device can deliver the composition to a surgical site. The composition can be a putty-like material that sets over time at the surgical site, such as a hemostatic device or a device for sealing a hole or cavity in bone.
    Type: Grant
    Filed: November 1, 2016
    Date of Patent: April 3, 2018
    Assignee: Abyrx Inc.
    Inventor: John Pacifico
  • Patent number: 9877761
    Abstract: Described herein are applicators for delivery of a viscous material to a bone surface and methods of use. The applicator includes an elongate handle portion and a tip coupled to a distal location of the handle portion and formed of an elastomeric material configured to conform to the bone surface. The tip includes a bend a distance away from the distal location, a contact surface distal to the bend and including one or more surface features configured to adhere to the viscous material, and a front end having a conic curvature. The bend is between about 20 degrees to about 40 degrees from a longitudinal axis of the tip.
    Type: Grant
    Filed: June 7, 2012
    Date of Patent: January 30, 2018
    Assignee: Abyrx Inc.
    Inventors: Jeffrey Kapec, Kazuna Tanaka, Yukiko Naoi, Marci Wirtz
  • Patent number: 9827349
    Abstract: The present invention relates to settable compositions for use in surgery. The invention also provides related compositions, including surgical kits and packages, as well as methods of making and using the settable compositions.
    Type: Grant
    Filed: November 25, 2014
    Date of Patent: November 28, 2017
    Assignee: Abyrx Inc.
    Inventors: John Pacifico, Aniq Darr, Richard L. Kronenthal
  • Patent number: 9314547
    Abstract: The present invention relates to absorbable polyurethane compositions suitable for use in bone repair or reconstruction. The present invention relates to the field of polyurethane-based cements, and putties for use in bone hemostasis, repair and reconstruction. The putty compositions may comprise a mixture of two or more individual putties formed through mixing of one or more reactive components and one or more additive (filler) components. Also disclosed herein are methods of using the putty compositions in medical applications to repair gaps or fractures, or to aid in tissue growth or adhesion.
    Type: Grant
    Filed: September 5, 2012
    Date of Patent: April 19, 2016
    Assignee: Abyrx Inc.
    Inventors: Rao Bezwada, Aniq Darr, Richard L. Kronenthal, John Pacifico
  • Patent number: 8852199
    Abstract: A bone adhesive application device has a pliable structure with an application surface upon which a bone adhesive may be applied. The application surface has a surface energy substantially equal to or less than a surface energy of the bone adhesive to reduce adhesion between the bone adhesive and the bone adhesive application device. The bone adhesive application device may be included in a kit for repairing bone defects having a bone adhesive formed from a reactive biocompatible polyurethane material. The bone adhesive may be applied to a bone defect by positioning the pliable structure over at least a portion of the bone defect, delivering the bone adhesive to the bone defect and removing the pliable structure from the bone adhesive.
    Type: Grant
    Filed: August 6, 2010
    Date of Patent: October 7, 2014
    Assignee: ABYRX, Inc.
    Inventors: Richard J. Deslauriers, Steven Joseph Beer, Eric Kolb, Joseph Jannetty
  • Publication number: 20140275287
    Abstract: The present invention relates to water soluble and completely absorbable and/or physiologically degradable hemostatic compositions having a wax or wax-like base effective for use in tamponade hemostasis of bone or cartilage.
    Type: Application
    Filed: November 1, 2012
    Publication date: September 18, 2014
    Applicant: ABYRX, INC.
    Inventors: David Knaack, John Pacifico, Marci Wirtz, Richard L. Kronenthal, Frank Do, Aniq Darr
  • Publication number: 20140213688
    Abstract: The present invention relates to absorbable polyurethane compositions suitable for use in bone repair or reconstruction. The present invention relates to the field of polyurethane-based cements, and putties for use in bone hemostasis, repair and reconstruction. The putty compositions may comprise a mixture of two or more individual putties formed through mixing of one or more reactive components and one or more additive (filler) components. Also disclosed herein are methods of using the putty compositions in medical applications to repair gaps or fractures, or to aid in tissue growth or adhesion.
    Type: Application
    Filed: September 5, 2012
    Publication date: July 31, 2014
    Applicant: ABYRX, INC.
    Inventors: Rao Bezwada, Aniq Darr, Richard L. Kronenthal, John Pacifico
  • Patent number: 8668697
    Abstract: A method for closing a sternum separated into at least a first sternum portion and a second sternum portion includes preparing at least one cut surface of at least one of the first or second sternum portions to have an adhesive applied thereon. The adhesive is applied to at least a portion of the at least one cut surface. The at least one cut surface is approximated to a second cut surface of the other of the first sternum portion or second sternum portion. As the adhesive cures, it bonds with the first cut surface and the second cut surface. Preparing the at least one cut surface may remove contaminants that could inhibit adhesion of the adhesive. The adhesive may be applied through adhesive injection holes formed along an incision separating the first and second sternum portions. Devices for preparing the cut surfaces and applying the adhesive are also provided.
    Type: Grant
    Filed: August 24, 2010
    Date of Patent: March 11, 2014
    Assignee: ABYRX, Inc.
    Inventors: Richard J. Deslauriers, Eric Kolb
  • Publication number: 20140066523
    Abstract: The invention provides moldable drug delivery carriers made up of a suspension of a solid phase and an organic liquid phase for the sustained release of a therapeutic agent. The invention also provides multiphase drug delivery systems made up of a granular hydrophobic solid phase, an organic liquid phase and a hydrogel, for sustained drug delivery at varying rates over the life of the composition.
    Type: Application
    Filed: May 1, 2012
    Publication date: March 6, 2014
    Applicant: ABYRX, Inc.
    Inventors: David Knaack, Ankur Gandhi, Jordan Katz, Marci Wirtz, Richard L. Kronenthal
  • Patent number: 8603528
    Abstract: At least three component, body-implantable, absorbable, biocompatible, putty, and non-putty pain-relieving compositions for use in surgery comprising in intimate admixture: an analgesic having local pain-relieving activity for internal relief of pain, a finely powdered bulking material, preferably less than 50 microns, e.g. the metal salts of fatty acid, hydroxyapatite, DBM, polyglycolide, polylactide, polycaprolactones, absorbable glasses, gelatin, collagens, mono, and polysaccharides starches. An organic liquid capable of solubilizing, dispensing or suspending the analgesic, such as esters of monohydric alcohols with aliphatic monocarboxylic acids; C2-C18 monohydric alcohols with polycarboxylic acids; C8-C30 monohydric alcohols; tocopherol and esters thereof with mono or polycarboxylic acids; free carboxylic acids such as oleic, capric, and lauric; dialkyl ethers and ketones; polyhydroxy compounds and esters and ethers thereof; random or block copolymers of ethylene oxide and propylene oxide.
    Type: Grant
    Filed: July 25, 2006
    Date of Patent: December 10, 2013
    Assignee: ABYRX, Inc.
    Inventor: Richard L. Kronenthal