Abstract: Specific conjugates containing auristatins and a binding protein or peptide, and processes for making them, are described. The conjugates use specific linker technology which gives advantages over known antibody-drug conjugates. Also described are specific conjugates of drugs and a binding protein or peptide in which more than one copy of the drug is present.
Type:
Application
Filed:
September 17, 2021
Publication date:
March 3, 2022
Applicant:
ABZENA (UK) LIMITED
Inventors:
John BURT, Antony GODWIN, Mark FRIGERIO, George BADESCU