Patents Assigned to Academia Sinica
  • Patent number: 10967361
    Abstract: Disclosed herein are carbon doped tin disulphide (C—SnS2) and other SnS2 composites as visible light photocatalyst for CO2 reduction to solar fuels. The in situ carbon doped SnS2 photocatalyst provide higher efficiency than the undoped pure SnS2. Also disclosed herein are methods for preparing the catalysts.
    Type: Grant
    Filed: March 29, 2018
    Date of Patent: April 6, 2021
    Assignees: ACADEMIA SINICA, NATIONAL TAIWAN UNIVERSITY
    Inventors: Kuei-Hsien Chen, Indrajit Shown, Wei-Fu Chen, Li-Chyong Chen Lin
  • Patent number: 10971677
    Abstract: An electrically controlled nanomagnet and a spin orbit torque magnetic random access memory (SOT-MRAM) including the same are provided. The electrically controlled nanomagnet includes: a first spin-Hall material layer including a first spin-Hall material; a second spin-Hall material layer including a second spin-Hall material; and a first magnetic layer disposed between the first spin-Hall material layer and the second spin-Hall material layer, wherein the first spin-Hall material and the second spin-Hall material are substantially mirror image to each other.
    Type: Grant
    Filed: December 11, 2019
    Date of Patent: April 6, 2021
    Assignee: ACADEMIA SINICA
    Inventors: Hsin Lin, Shih-Yu Wu, Chuang-Han Hsu
  • Patent number: 10941130
    Abstract: This invention relates to a novel molten salt system in chemical transformation of saccharides and a method as well as an apparatus for multi carbon production by the molten salt system. It is found that an eutectic molten salt composition is advantageous for multi-carbon productions through chemical transformation under mild conditions. This invention further provides a method and an apparatus for preparing 5-hydroxymethylfurfural (HMF) and HMF-derived chemicals from saccharides by the said molten salt system.
    Type: Grant
    Filed: March 22, 2019
    Date of Patent: March 9, 2021
    Assignee: Academia Sinica
    Inventors: Po-Wen Chung, Prasenjit Bhaumik, Hao-Ju Chou
  • Publication number: 20210046479
    Abstract: Disclosed herein is an integrated microfluidic chip for detecting cancerous cells, particularly, cholangio-cancerous cells, from a biological sample. Also disclosed herein is a method of detecting cholangio-cancerous cells from a biological sample.
    Type: Application
    Filed: February 27, 2019
    Publication date: February 18, 2021
    Applicants: Academia Sinica, National Tsing Hua University
    Inventors: Shang-Cheng HUNG, Yen-Chun KO, Cheng-Fang TSAI, Gwo-Bin LEE, Wei-Chun TSAI
  • Patent number: 10918714
    Abstract: Glycosphingolipids (GSLs) bearing ?-glucose (?-Glc) that preferentially stimulate human invariant NKT (iNKT) cells are provided. GSLs with ?-glucose (?-Glc) that exhibit stronger induction in humans (but weaker in mice) of cytokines and chemokines and expansion and/or activation of immune cells than those with ?-galactose (?-Gal) are disclosed. GSLs bearing ?-glucose (?-Glc) and derivatives of ?-Glc with F at the 4 and/or 6 positions are provided. Methods for iNKT-independent induction of chemokines by the GSL with ?-Glc and derivatives thereof are disclosed. Methods for immune stimulation in humans using GSLs with ?-Glc and derivatives thereof are provided.
    Type: Grant
    Filed: October 30, 2018
    Date of Patent: February 16, 2021
    Assignee: ACADEMIA SINICA
    Inventors: Chi-Huey Wong, Alice L. Yu, Kun-Hsien Lin, Tai-Na Wu
  • Patent number: 10912832
    Abstract: Disclosed herein is a multiple drugs delivery system and its uses in treating diseases. The multiple drugs delivery system includes, an anti-PEG antibody for directing the PEGylated therapeutic to the treatment site; and a hydrogel for retaining the anti-PEG antibody and/or the PEGylated therapeutic at the treatment site for at least 3 days. The hydrogel is selected from the group consisting of hyaluronan (HA) or a derivative of HA, collagen, gelatin, fibronectin, fibrinogen, alginate, chitosan, and a synthetic biocompatible polymer. The anti-PEG antibody and the hydrogel are present in the mixture in a ratio from about 1:1 (v/v) to 1:100 (v/v). At least two dosages of the PEGylated therapeutic, which may be the same or different, are administered to the subject, with each dosage being given at about 1 hour to about 1 week apart. Accordingly, a novel method of treating a subject having cancer or ischemia disease is also provided.
    Type: Grant
    Filed: November 27, 2019
    Date of Patent: February 9, 2021
    Assignee: ACADEMIA SINICA
    Inventors: Patrick C. H. Hsieh, Pei-Jung Wu, Steve Roffler, Bill Cheng
  • Patent number: 10912777
    Abstract: A pharmaceutical composition comprising (i) a therapeutically effective amount of an inhibitor of the oncogene SLC29A2; and (ii) a pharmaceutically acceptable carrier, for use in suppressing proliferation, occurrence, and metastasis of cancer cells overexpressing the oncogene SLC29A2 in a cancer patient, and/or prolonging cancer patient survival. The inhibitor of the oncogene SLC29A2 may be at least one selected from the group consisting of dipyridamole, dilazep, draflzine, nitorbenzylthioinosine, and the derivatives thereof. The composition for use may further comprise sorafenib for the same use.
    Type: Grant
    Filed: December 19, 2017
    Date of Patent: February 9, 2021
    Assignee: ACADEMIA SINICA
    Inventors: Yuh-Shan Jou, Roger Shen
  • Publication number: 20210030825
    Abstract: A method for treating breast cancer and/or treating breast cancer metastasis in a subject in need of such treatment including administering to said subject an effective amount of Crassocephalum rabens extract and optionally a pharmaceutically acceptable carrier or excipient.
    Type: Application
    Filed: May 29, 2018
    Publication date: February 4, 2021
    Applicant: ACADEMIA SINICA
    Inventors: LIE-FEN SHYUR, MARIA KARMELLA APAYA, MENG-TING CHANG
  • Patent number: 10894037
    Abstract: Disclosed herein are novel uses of a compound of formula (I) as an inhibitor of bacterial two component signal transduction system (TCS), A-L-B-L-A??(I) wherein, A is a moiety having a negative charge; L is —(C2H5—O)n—CH2— or a moiety consists of a carbocyclyl and a heterocyclyl respectively having 5 to 10 ring atoms and coupling together, in which n is 0 or 1; and B is a 5 to 10-membered carbocyclyl or heterocyclyl. The compound of formula (I) may suppress or inhibit the growth of bacteria, including the notorious multi-drug resistant bacteria.
    Type: Grant
    Filed: December 27, 2018
    Date of Patent: January 19, 2021
    Assignee: ACADEMIA SINICA
    Inventors: Chinpan Chen, Tien-Sheng Tseng, Keng-Chang Tsai
  • Patent number: 10889611
    Abstract: Disclosed herein are novel sialyltransferase inhibitors, and compositions and methods for treating diseases and/or conditions associated with the activation of sialyltransferase, such as a cancer, an immune disease or an inflammatory disease.
    Type: Grant
    Filed: August 26, 2016
    Date of Patent: January 12, 2021
    Assignee: Academia Sinica
    Inventors: Wen-Shan Li, Wen-Chun Hung, Chia-Ning Shen
  • Patent number: 10882890
    Abstract: Bipartite molecules comprising a peptide affinity moiety and at least one charged moiety and uses thereof in reducing formation of abnormal protein aggregate and treating diseases associated with such abnormal protein aggregate, including neurodegenerative disease characterized by formation of protein aggregates.
    Type: Grant
    Filed: July 24, 2015
    Date of Patent: January 5, 2021
    Assignee: ACADEMIA SINICA
    Inventors: Benjamin Pang-Hsien Tu, Rita Py Chen, Joseph Jen-Tse Huang, Yijuang Chern, Yu-Song Jang, Xiang-Me Lai, Tai-Yan Liao, Te-Hsien Kung
  • Patent number: 10865397
    Abstract: Disclosed herein are recombinant polynucleotide sequences, vectors, host cells and methods for producing astaxanthin. The recombinant polynucleotide sequence is designed to provide a higher level of astaxanthin precursors via a shorter metabolic pathway, and thereby attains higher level of end products (e.g., astaxanthin) with desired stereoisomeric form and/or esterified form.
    Type: Grant
    Filed: November 26, 2018
    Date of Patent: December 15, 2020
    Assignee: ACADEMIA SINICA
    Inventors: Jui-Jen Chang, Caroline Thia, Hao-Yeh Lin, Yu-Ju Lin, Chieh-Chen Huang, Wen-Hsiung Li
  • Patent number: 10835493
    Abstract: Proteo-microparticles such as proteoliposomes comprising a microparticle (e.g., a liposome) and platelet membrane proteins, wherein the proteo-microparticles are capable of binding to monocytes, neutrophils, or other circulating blood cells capable of migrating to an injured site. Also provided herein are uses of the proteoliposomes for delivering a therapeutic agent via monocytes to an injured site.
    Type: Grant
    Filed: April 20, 2016
    Date of Patent: November 17, 2020
    Assignee: ACADEMIA SINICA
    Inventors: Patrick C. H. Hsieh, Bill Cheng
  • Publication number: 20200339584
    Abstract: Disclosed herein are novel bifunctional compounds and their uses for the treatment and/or prophylaxis of cancers. The bifunctional compound disclosed herein has the structure of formula (I).
    Type: Application
    Filed: November 16, 2018
    Publication date: October 29, 2020
    Applicant: Academia Sinica
    Inventors: Te-Chang LEE, Tsann-Long SU, Tai-Lin CHEN
  • Patent number: 10804431
    Abstract: Current-injecting nanorod LEDs are demonstrated to emit linear polarized light that is detected from the backside of the sample. The polarization ratio of the electroluminescence reaches 71% when the length of the minor axis is as small as 150 nm. Electromagnetic simulation confirms the occurrence of the polarization selectivity especially when the length of the minor axis is down to 150 nm. The destructive interference between the light directly from light source and the reflected light by the top metal interface is the origin of the selectivity. Emission with the polarization perpendicular to the nanorods is extracted out of the nanorods and the remaining light with the other polarization transmits to the substrate. The linearly polarized light can be also detected from the front side of the sample if the conductive pad is transparent. The simulation also suggests that it is possible to obtain circularly or elliptically polarized light by tuning the height of the nanorods.
    Type: Grant
    Filed: January 9, 2019
    Date of Patent: October 13, 2020
    Assignee: ACADEMIA SINICA
    Inventor: Yun-Chorng Chang
  • Patent number: 10793628
    Abstract: Methods and compositions for treatment and therapy of cancer are provided. Specifically, antagonists specific for interleukin-17 receptor B (IL-17RB) and its ligand IL-17B are provided. Potent neutralizing antibodies specific for IL-17RB and methods for their manufacture and use are disclosed. The invention also relates to antisense, RNAi and shRNA compositions for the prevention and treatment of cancer, in particular breast cancer and pancreatic cancer.
    Type: Grant
    Filed: June 30, 2015
    Date of Patent: October 6, 2020
    Assignee: Academia Sinica
    Inventors: Wen-Hwa Lee, Jin-Yuh Shew, Che Ma, Chia-Lin Chen, Wen-Hsin Lee, Chun-Kai Huang, Heng-Hsiung Wu
  • Patent number: 10796788
    Abstract: This invention discloses a method for constructing a set of database of one or more saccharides, a logical procedure for automatic determination of sequential mass spectra, and a method, program and system for determination the structures of oligosaccharides and glycoconjugates by the set of database. In one aspect, the sequential mass spectra measured by the method, program or system of the invention maybe instructed according to the logical procedure automatically or manually determined. By comparing the sequential mass spectra to the set of database, the structure of the carbohydrate comprising linkage position, anomeric configuration, composed monosaccharide and branch location of the carbohydrate sample can be identified. In another aspect, the method, program may be used to control one or more mass spectrometer automatically or manually.
    Type: Grant
    Filed: June 18, 2018
    Date of Patent: October 6, 2020
    Assignee: Academia Sinica
    Inventors: Chi-Kung Ni, Shang-Ting Tsai, Hsu-Chen Hsu, Chia-Yen Liew, Shih-Pei Huang
  • Publication number: 20200299249
    Abstract: This invention relates to a novel molten salt system in chemical transformation of saccharides and a method as well as an apparatus for multi carbon production by the molten salt system. It is found that an eutectic molten salt composition is advantageous for multi-carbon productions through chemical transformation under mild conditions. This invention further provides a method and an apparatus for preparing 5-hydroxymethylfurfural (HMF) and HMF-derived chemicals from saccharides by the said molten salt system.
    Type: Application
    Filed: March 22, 2019
    Publication date: September 24, 2020
    Applicant: ACADEMIA SINICA
    Inventors: Po-Wen CHUNG, Prasenjit BHAUMIK, Hao-Ju CHOU
  • Publication number: 20200299329
    Abstract: Disclosed herein is a biomolecule comprising a synthetic peptide for targeting thrombus, a pharmaceutical composition comprising the same, and uses thereof in the treatment of thromboembolism-related diseases. According to embodiments of the present disclosure, the synthetic peptide having the amino acid sequence of SEQ ID NO: 1, 2, or 3 exhibits a binding affinity and specificity to thrombus. Thus, the synthetic peptide may serve as a targeting element for delivering a therapeutic agent (e.g., an anticoagulant agent or a thrombolytic agent) to the thrombus thereby improving the therapeutic safety and efficacy of the therapeutic agent.
    Type: Application
    Filed: March 19, 2020
    Publication date: September 24, 2020
    Applicant: Academia Sinica
    Inventors: Han-Chung WU, Yuan-Sung KUO
  • Patent number: 10784343
    Abstract: The present invention discloses a Nanowire Field Effect Transistor Detection Device and the Detection Method thereof. The Nanowire Field Effect Transistor Detection Device of the present invention comprises: gate oxide, SiNW chip, surface oxide, and surface molecule layer. The circuit structure of the Nanowire Field Effect Transistor Detection Device comprises a first resistor, a second resistor, a first capacitor, a second capacitor, a third capacitor, a fourth capacitor, an AC voltage source, and an ammeter. In addition, the present invention provides a method for attaching the probe Ni-NTA to the Nanowire Field Effect Transistor Detection Device. Furthermore, the present invention provides a method for attaching the isooctyl trimethoxysilane molecule to the Nanowire Field Effect Transistor Detection Device.
    Type: Grant
    Filed: December 28, 2017
    Date of Patent: September 22, 2020
    Assignee: ACADEMIA SINICA
    Inventors: Chii Dong Chen, Li Chu Tsai, Chia Jung Chu, Ying Pin Wu