Patents Assigned to Academia Sinica
  • Publication number: 20240110916
    Abstract: Disclosed herein is a method for identifying and treating an early-stage hepatocellular carcinoma (HCC) in a subject. The method mainly includes determining the level of serum amyloid A (SAA) protein, and providing anti-cancer treatment based on the determined level of SAA protein. According to some embodiments of the present disclosure, the anti-cancer treatment is provided when the determined level of SAA protein is lower than that of a first control sample, or when the determined level of SAA protein is higher than that of a second control sample. In some embodiments, the first control sample is derived from a subject having a late stage HCC, and the second control sample is derived from a subject having a liver disease that is any of hepatitis, liver cirrhosis, or a combination thereof.
    Type: Application
    Filed: January 21, 2022
    Publication date: April 4, 2024
    Applicant: Academia Sinica
    Inventors: Yun-Ru CHEN, Jin-Lin WU, Pei-Jer CHEN, Tung-Hung SU
  • Publication number: 20240110139
    Abstract: A surface coating comprising a hydrophilic polymer and polyelectrolyte multilayers. Also, a cell culture system including a cell culture article having a surface coated with the surface coating. Also, methods of preparing the surface coatings and systems.
    Type: Application
    Filed: December 30, 2021
    Publication date: April 4, 2024
    Applicant: ACADEMIA SINICA
    Inventor: YING-CHIH CHANG
  • Patent number: 11932973
    Abstract: A method for manufacturing a polymer-based fibrous scaffold is disclosed. The method includes the following step: providing an electrospinning device comprising a collector; and injecting a polymer solution into the electrospinning device to produce a single jet fiber, wherein the single jet fiber is piled on the collector to form a fibrous scaffold.
    Type: Grant
    Filed: October 27, 2021
    Date of Patent: March 19, 2024
    Assignee: ACADEMIA SINICA
    Inventors: Chia-Fu Chou, Balchandar Navaneethan
  • Patent number: 11918641
    Abstract: The present disclosure relates to a chimeric influenza virus hemagglutinin (HA) polypeptide, comprising one or more stem domain sequence, each having at least 60% homology with a stem domain consensus sequence of H1 subtype HA (H1 HA) and/or H5 subtype HA (H5 HA), fused with one or more globular head domain sequence, each having at least 60% homology with a globular head domain consensus sequence of H1 subtype HA (H1 HA) or H5 subtype HA (H5 HA).
    Type: Grant
    Filed: May 7, 2021
    Date of Patent: March 5, 2024
    Assignee: ACADEMIA SINICA
    Inventors: Chi-Huey Wong, Hsin-Yu Liao, Shih-Chi Wang, Yi-An Ko, Kuo-I Lin, Che Ma, Ting-Jen Cheng
  • Patent number: 11919886
    Abstract: The present disclosure provides compounds of Formulas (I), (II), and pharmaceutically acceptable salts thereof. The compounds described herein are useful in treating proliferative diseases, for example, cancer (e.g., lung cancer), and infectious diseases (e.g., bacterial infections).
    Type: Grant
    Filed: July 12, 2022
    Date of Patent: March 5, 2024
    Assignees: Academia Sinica, National Taiwan University
    Inventors: Chi-Huey Wong, Pan-Chyr Yang, Rong-Jie Chein, Szu-Hua Pan, Ting-Jen R. Cheng
  • Patent number: 11918000
    Abstract: The present disclosure relates to fungi, a culture filtrate thereof and a polysaccharide and their applications in inducing or priming plant resistance to viruses. Aspects of the present disclosure provides a cultured filtrate, derived from a fungus belonging to the genus Trichosporon, induces strong resistance to various viruses on different plants.
    Type: Grant
    Filed: June 5, 2019
    Date of Patent: March 5, 2024
    Assignee: ACADEMIA SINICA
    Inventors: Hsin-Hung Yeh, Yi-Shu Chiu
  • Patent number: 11918975
    Abstract: Disclosed is a modified carbonaceous material, which includes hexagonal carbon networks in a layered stacking structure and acidic functional groups bonded to the hexagonal carbon networks and mainly existing at edges of the layered carbonaceous structure. Accordingly, the close proximity of acid moiety at the edges can resemble the center of hydrolysis enzymes, resulting in enhancement of hydrolytic efficiency. Additionally, the acid-functionalized carbonaceous material can also be applied in the capture and storage of carbon dioxide due to its unexpectedly higher capacity for CO2 molecular.
    Type: Grant
    Filed: June 18, 2019
    Date of Patent: March 5, 2024
    Assignee: ACADEMIA SINICA
    Inventors: Jia-Hui Wang, Hao-Ju Chou, Po-Wen Chung
  • Publication number: 20240032825
    Abstract: The PPG based NIBG neural network prediction system of the present invention comprises a neural network configured to predict BG level of a subject based on PPG signal obtained from the subject wherein the subject is not undergoing medical treatment and the neural network is trained using training data from subjects not undergoing medical treatment. In another embodiment, the PPG based NIBG neural network prediction system of the present invention predicts BG level of a subject based on HbA1c of the subject measured using conventional finger prick method as well as PPG signal obtained from the subject wherein the subject is not undergoing medical treatment and the neural network is trained using training data from subjects not undergoing medical treatment.
    Type: Application
    Filed: July 29, 2022
    Publication date: February 1, 2024
    Applicant: Academia Sinica
    Inventors: Fu-Liang Yang, Justin Chu
  • Patent number: 11884739
    Abstract: The present disclosure relates to a novel class of anti-CD20 monoclonal antibodies comprising a homogeneous population of anti-CD20 IgG molecules having the same N-glycan on each of Fc. The antibodies of the invention can be produced from anti-CD20 monoclonal antibodies by Fc glycoengineering. Importantly, the antibodies of the invention have improved therapeutic values with increased ADCC activity and increased Fc receptor binding affinity compared to the corresponding monoclonal antibodies that have not been glycoengineered.
    Type: Grant
    Filed: March 24, 2021
    Date of Patent: January 30, 2024
    Assignee: ACADEMIA SINICA
    Inventors: Chi-Huey Wong, Chung-Yi Wu, Ming-Hung Tsai
  • Patent number: 11879006
    Abstract: Disclosed herein is a recombinant antibody exhibiting binding affinity and/or neutralizing activity to porcine epidemic diarrhea virus (PEDV). According to some embodiments of the present disclosure, the PEDV is genotype 1 (G1) or genotype 2b (G2b) PEDV. Also disclosed herein are methods of diagnosing and treating PEDV infection by use of the present recombinant antibody.
    Type: Grant
    Filed: June 28, 2022
    Date of Patent: January 23, 2024
    Assignee: Academia Sinica
    Inventors: Shang-Te Danny Hsu, Hui-Wen Chang, Chia-Yu Chang
  • Patent number: 11872260
    Abstract: This disclosure is directed to essential oils, and methods of their use in treating skin conditions. The skin conditions include those involving HRASQ61L mutant keratinocyte activity, wherein the essential oil inhibits said activity to treat and/or prevent skin cancer. Particularly, the present invention denotes to and composition for inhibiting and prevent skin carcinogenesis or BRAF inhibitor, a type of anti-cancer drug induced cutaneous side effect.
    Type: Grant
    Filed: September 27, 2019
    Date of Patent: January 16, 2024
    Assignee: ACADEMIA SINICA
    Inventors: Lie-Fen Shyur, Chih-Ting Chang, Yuhsin Chen
  • Patent number: 11866489
    Abstract: An isolated anti-SCUBE2 antibody or a binding fragment thereof is disclosed. The anti-SCUBE2 antibody comprises an antigen binding region that specifically binds to a target domain located within SCUBE2 (SEQ ID NO: 66) and exhibits a property of inhibiting VEGF-induced angiogenesis. The target domain is selected from the group consisting of the EGF-like motifs 4 to 6 ranging from a.a. position 175 to 323, or the spacer region ranging from a.a. position 441 to 659, or the first cys-rich motif ranging from a.a. position 668 to 725 of SCUBE2 (SEQ ID NO: 66). The anti-SCUBE2 antibody or binding fragment thereof is for use in treating a disease associated with VEGF-induced angiogenesis, or for use in treating a tumor or inhibiting tumor angiogenesis and cancer cell growth in a subject in need thereof.
    Type: Grant
    Filed: June 8, 2021
    Date of Patent: January 9, 2024
    Assignee: ACADEMIA SINICA
    Inventors: Ruey-Bing Yang, Yuh-Charn Lin
  • Patent number: 11866485
    Abstract: The present disclosure relates to an antibody or antigen-binding fragment thereof that specifically binds to a spike protein of SARS-CoV-2. The present disclosure also relates to a pharmaceutical composition, a method for treating and/or preventing diseases and/or disorders caused by a coronavirus in a subject in need thereof, and a method for detecting a coronavirus in a sample.
    Type: Grant
    Filed: October 3, 2022
    Date of Patent: January 9, 2024
    Assignee: ACADEMIA SINICA
    Inventors: Kuo-I Lin, Che Ma, Chi-Huey Wong, Szu-Wen Wang, Yi-Hsuan Chang, Xiaorui Chen, Han-Yi Huang
  • Patent number: 11858965
    Abstract: The present disclosure relates to a recombinant protein comprising a plurality of type II cohesin repeats. The present disclosure provides a recombinant cellulosome complex comprising: the recombinant protein comprising a plurality of type II cohesin repeats; a recombinant cellulosome complex integrating protein A comprising a plurality of type I cohesin repeats, a plurality of cellulose-binding modules and a type II dockerin; and a plurality of recombinant enzymes each comprising a type I dockerin. A cell, a method for digesting a cellulose and a method for producing ethanol are also provided.
    Type: Grant
    Filed: May 21, 2021
    Date of Patent: January 2, 2024
    Assignee: ACADEMIA SINICA
    Inventors: Wen-Hsiung Li, Anandharaj Marimuthu, Jui-Jen Chang, Yu-Ju Lin, Rizwana Parveen Rani Mohamed Gobil, Chieh-Chen Huang
  • Patent number: 11859237
    Abstract: A method for sizing a DNA molecule is disclosed, which comprises the following steps of: providing a DNA sizing device, comprising: a cover substrate; a substrate disposed on the cover substrate and comprising a first hole and a second hole; and a first slit-like channel disposed between the cover substrate and the substrate, wherein two ends of the first slit-like channel respectively connects to the first hole and the second hole; loading a sample comprising a DNA molecule to the first slit-like channel through the first hole, wherein the DNA molecule moves in a direction from the first hole to the second hole; detecting and recording an intensity and an area of a distribution of the DNA molecule; and analyzing the intensity and the area to obtain the size of a DNA molecule.
    Type: Grant
    Filed: November 8, 2019
    Date of Patent: January 2, 2024
    Assignee: ACADEMIA SINICA
    Inventors: Chia-Fu Chou, Jia-Wei Yeh, Yii-Lih Lin
  • Publication number: 20230381761
    Abstract: Disclosed herein are novel catalysts for producing remdesivir in one-pot manner, in which a diastereomerically enriched form of an intermediate, which following acidic hydrolysis would give rise to the desired remdesivir, was produced with the aid of the disclosed novel catalysts. Also disclosed herein is an improved process for the preparation of remdesivir without the need to separate one of the enantiomers while minimizing the formation of undesired isomers, thus offers economic advantages for operation on a commercial scale.
    Type: Application
    Filed: October 7, 2021
    Publication date: November 30, 2023
    Applicant: Academia Sinica
    Inventors: Shang-Cheng HUNG, Chi-Huey WONG, Veeranjaneyulu GANNEDI, Bharath Kumar VILLURI, Nimmakayala Sivakumar REDDY, Chiao-Chu KU
  • Patent number: 11826307
    Abstract: An external counter pulsation system (ECP) and method for using the system to improve circulation as well as cardiovascular related diseases. The ECP system of the present invention comprises a helical air bladder for modulating blood flow of major veins and arteries of the thigh. High efficiency is realized with the helical shape of the air bladder to lower the cost, weight and size of the ECP of the present invention.
    Type: Grant
    Filed: September 14, 2020
    Date of Patent: November 28, 2023
    Assignee: Academia Sinica
    Inventors: Fu-Liang Yang, Chang-Kuei Chung
  • Publication number: 20230365640
    Abstract: Disclosed herein is a CLEC2 fusion protein comprising a first polypeptide and a second polypeptide coupled to the upstream of the first polypeptide. According to embodiments of the present disclosure, the first and the second polypeptides respectively comprise the amino acid sequences of SEQ ID NOs: 1 and 2. Also disclosed therein are uses of the CLEC2 fusion protein in treating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and treating influenza virus infection.
    Type: Application
    Filed: September 29, 2021
    Publication date: November 16, 2023
    Applicant: Academia Sinica
    Inventors: Shie-Liang HSIEH, Pei-Shan SUNG
  • Patent number: 11813317
    Abstract: Provided is a method for preventing or treating a metabolic disorder, including administering to a subject a therapeutically effective amount of TRABID protein or a functionally related variant thereof, or a nucleic acid encoding TRABID protein or a functionally related variant thereof. Also provided is a method for reducing fat accumulation through TRABID-induced deubiquitination to promote autophagy activity and lipid metabolism.
    Type: Grant
    Filed: December 2, 2021
    Date of Patent: November 14, 2023
    Assignees: Academia Sinica, National Yang Ming Chiao Tung University
    Inventors: Ruey-Hwa Chen, Yu-Hsuan Chen, Tzu-Yu Huang, Wen-Hsin Li, Ting-Fen Tsai, Zhao-Qing Shen
  • Patent number: 11813326
    Abstract: This disclosure provides treatment kit that are capable of modulating the immune response. The treatment kit may also be used enhance the immunogenicity of antigens released from cell debris. Also provided are methods of using the treatment kit.
    Type: Grant
    Filed: January 3, 2019
    Date of Patent: November 14, 2023
    Assignee: ACADEMIA SINICA
    Inventors: Che-Ming Jack Hu, Saborni Chattopadhyay