Patents Assigned to Academia Sinica, Taiwan
  • Five-membered iminocyclitol derivatives as selective and potent glycosidase inhibitors: new structures for antivirals and osteoarthritis therapeutics
    Patent number: 8273788
    Abstract: Novel 5-membered iminocyclitol derivatives were found to be a potent and selective inhibitors of the glycoprotein processing ?- and ?-glucosidase which were further found to be active antiviral agents against Japanese encephalitis virus, dengue virus serotype 2 (DEN-2), human SARS coronavirus and human ?-hexosaminidase, a new target for development of osteoarthritis therapeutics.
    Type: Grant
    Filed: February 24, 2011
    Date of Patent: September 25, 2012
    Assignee: Academia Sinica, Taiwan
    Inventors: Pi-Hui Liang, Yi-Ling Lin, Chi-Huey Wong
  • Protein expression system involving mutated severe respiratory syndrome-associated coronavirus 3C-like protease
    Patent number: 8053222
    Abstract: A mutated severe acute respiratory syndrome-associated coronavirus 3C-like protease and use thereof for cleaving a protein that includes a cleavage site recognizable by the mutated protease to yield a polypeptide fragment of interest.
    Type: Grant
    Filed: February 12, 2009
    Date of Patent: November 8, 2011
    Assignee: Academia Sinica, Taiwan
    Inventors: Po-Huang Liang, Chih-Jung Kuo, Yan-Ping Shih
  • SUMO fusion protein expression system for producing native proteins
    Patent number: 8034910
    Abstract: A simple and efficient SUMO fusion protein expression system for producing native proteins.
    Type: Grant
    Filed: May 6, 2009
    Date of Patent: October 11, 2011
    Assignee: Academia Sinica, Taiwan
    Inventor: Ting-Fang Wang
  • Heterarylbenzene compounds
    Publication number: 20030111956
    Abstract: A method of preparing a compound of formula I is described.
    Type: Application
    Filed: December 11, 2002
    Publication date: June 19, 2003
    Applicant: Academia Sinica, a Taiwan research institution
    Inventors: Jiann T?apos;Suen Lin, Iuan-Yuan Wu, Yu-Tai Tao, E. Balasubramaniam
  • HS-40 enhancer-containing vector
    Publication number: 20020108134
    Abstract: A viral expression vector having a nucleic acid which includes (1) a transcriptional start site; (2) a promoter operably linked to the transcriptional start site; and (3) an enhancer operably linked to the promoter, the enhancer comprising the DNA sequence of SEQ ID NO:1 or the RNA equivalent thereof.
    Type: Application
    Filed: October 15, 2001
    Publication date: August 8, 2002
    Applicant: Academia Sinica, a Taiwan corporation
    Inventor: Chen-Kun James Shen
  • Nucleic acid bulge-detecting agent
    Publication number: 20020095029
    Abstract: This invention relates to a metal complex of formula (I). The metal complex is capable of cleaving a bulge-containing nucleic acid at the bulge site with high specificity.
    Type: Application
    Filed: January 2, 2002
    Publication date: July 18, 2002
    Applicant: Academia Sinica, a Taiwan corporation
    Inventors: Chien-Chung Cheng, Wen Jwu Wang