Patents Assigned to Academic Pharmaceuticals, Inc.
  • Ultra short acting anti-arrhythmic agents
    Patent number: 11731938
    Abstract: Some aspects provide novel dofetilide derivatives and pharmaceutical compositions containing the same that are useful as pharmaceutical agents in the treatment of supraventricular and ventricular arrhythmias.
    Type: Grant
    Filed: December 22, 2021
    Date of Patent: August 22, 2023
    Assignee: Academic Pharmaceuticals Inc
    Inventors: John Somberg, Robert J Chorvat
  • Method of initiating or escalating dofetilide dose and formulations therefor
    Patent number: 11364213
    Abstract: The present invention provides a novel method of initiating or escalating dofetliide dosage with the goal of maximizing patient safety while shortening the time period required for electrocardiographic monitoring from three days to one day.
    Type: Grant
    Filed: June 24, 2019
    Date of Patent: June 21, 2022
    Assignee: Academic Pharmaceuticals Inc
    Inventor: John Somberg
  • Parenteral dextrose formulation of clopidogrel
    Patent number: 8513278
    Abstract: Described herein are ways to solubilize clopidogrel for parenteral administration containing clopidogrel and D50W, which is useful in the prevention of platelet aggregation in acute coronary syndrome, acute myocardial infarction or to prevent platelet facilitated thrombosis following coronary angioplasty and/or coronary stenting.
    Type: Grant
    Filed: November 26, 2012
    Date of Patent: August 20, 2013
    Assignee: Academic Pharmaceuticals, Inc.
    Inventor: John C Somberg
  • Formulation of aspirin that is stable and showing minimal hydrolysis for parenteral administration for the treatment of cardiovascular and other disease states
    Patent number: 8481600
    Abstract: Disclosed herein are ways to solubilize aspirin for parenteral administration containing aspirin and a diluent NNDMA (N,N-Dimethylacetamide) useful in the treatment of acute coronary syndromes as well as other disease states. The solution so constituted is stable at room temperature for prolonged periods without decomposition and avoids significant hydrolysis of the aspirin and thus the loss of the anti-platelet action when stored.
    Type: Grant
    Filed: May 26, 2009
    Date of Patent: July 9, 2013
    Assignee: Academic Pharmaceuticals, Inc.
    Inventors: John Charin Somberg, Vasant V Ranade
  • Optically active isomers of quinine and quinidine and their respective biological action
    Patent number: 6844355
    Abstract: The present invention provides methods for purifying, identifying and using optically active isomers of quinine and quinidine as well as compositions comprising such optically active isomers. Such optically active isomers having desired actions on cardiac sodium and potassium channel function substantially separable from undesirable effects on GI motility can be useful for more effective therapy of cardiac arrhythmias. Also disclosed are methods for assaying the levels of such isomers present in the biological fluids.
    Type: Grant
    Filed: December 22, 2000
    Date of Patent: January 18, 2005
    Assignee: Academic Pharmaceuticals, Inc.
    Inventors: John C. Somberg, Vasant Ranade
  • Parenteral solutions containing 7-halo-1,2,3,4-tetrahydro-3-aryl-6-quinazoline sulfonamides
    Patent number: 5684009
    Abstract: Disclosed herein are parenteral solutions containing 7-halo-1,2,3,4-tetrahydro-3-aryl-6-quinazoline sulfonamides in Bis-Tris buffer useful in the treatment of hypertension, heart disease and heart failure and renal disease. Also disclosed are methods for preparing such solutions.
    Type: Grant
    Filed: September 1, 1994
    Date of Patent: November 4, 1997
    Assignee: Academic Pharmaceuticals, Inc.
    Inventor: Vasant Ranade
  • Parenteral solutions containing amiodarone in acetate buffer solution
    Patent number: 5234949
    Abstract: Disclosed herein are parenteral solutions containing 3-diethylaminoethoxybenzoyl-benzofurans, such as amiodarone, in acetate buffer useful in the treatment of arrhythmias.
    Type: Grant
    Filed: April 1, 1992
    Date of Patent: August 10, 1993
    Assignee: Academic Pharmaceuticals, Inc.
    Inventors: Seymour Ehrenpreis, John C. Somberg