Patents Assigned to Academisch Medisch Centrum Bij De Universiteit Van Amsterdam
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Patent number: 10774308Abstract: The invention provides a method for influencing the stability of an antibody producing cell, comprising directly or indirectly influencing the amount of BCL6 and/or Blimp 1 expression product within said antibody producing cell. Stable antibody producing cells and cell lines are also provided, as well as methods for producing antibodies using such cells and/or cell lines.Type: GrantFiled: August 28, 2018Date of Patent: September 15, 2020Assignees: ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM, AIMM THERAPEUTICS B.V.Inventor: Hergen Spits
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Patent number: 10273454Abstract: The invention provides a method for influencing the stability of an antibody producing cell, comprising directly or indirectly influencing the amount of BCL6 and/or Blimp 1 expression product within said antibody producing cell. Stable antibody producing cells and cell lines are also provided, as well as methods for producing antibodies using such cells and/or cell lines.Type: GrantFiled: June 2, 2017Date of Patent: April 30, 2019Assignee: ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAMInventors: Hergen Spits, Ferenc A. Scheeren, Tim Beaumont, Sean A. Diehl
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Patent number: 10077427Abstract: The invention provides a method for influencing the stability of an antibody producing cell, comprising directly or indirectly influencing the amount of BCL6 and/or Blimp 1 expression product within said antibody producing cell. Stable antibody producing cells and cell lines are also provided, as well as methods for producing antibodies using such cells and/or cell lines.Type: GrantFiled: March 26, 2015Date of Patent: September 18, 2018Assignees: ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM, AIMM THERAPEUTICS B.V.Inventor: Hergen Spits
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Patent number: 9826950Abstract: A method to adjust or tune mechanical settings of a mammography apparatus comprising an x-ray source, a paddle and a detector with a detector cover, wherein before executing an x-ray measurement a patient's breast is placed and compressed between the detector cover and the paddle, wherein prior to the x-ray measurement reaction forces between the mammography apparatus and the patient's breast are minimized. The invention relates further to a mammography apparatus comprising an x-ray source, a paddle and a detector with a detector cover, which apparatus is provided with at least one weighing means to measure the downwards forces exerted by (the part of) the apparatus above the weighing means towards the ground.Type: GrantFiled: October 27, 2014Date of Patent: November 28, 2017Assignee: Academisch Medisch Centrum bij de Universiteit van AmsterdamInventors: Gerardus Johannes Den Heeten, Cornelis Antonius Grimbergen, Christiaan Neeleman
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Patent number: 9822339Abstract: The invention provides a method for influencing the stability of an antibody producing cell, comprising directly or indirectly influencing the amount of BCL6 and/or Blimp 1 expression product within said antibody producing cell. Stable antibody producing cells and cell lines are also provided, as well as methods for producing antibodies using such cells and/or cell lines.Type: GrantFiled: August 26, 2015Date of Patent: November 21, 2017Assignees: ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM, AIMM THERAPEUTICS B.V.Inventors: Hergen Spits, Ferenc A. Scheeren, Tim Beaumont, Sean A. Diehl
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Patent number: 9743997Abstract: A mammography apparatus is provided for detecting malignant cells in a breast, comprising an x-ray source and an x-ray detector that cooperates with the x-ray source for providing an x-ray image of said breast, and further comprising a paddle for flattening the breast by pressing it against said x-ray detector, and comprising a contact area measuring device for measuring a contact area between the breast and the paddle, wherein the contact area measuring device is embodied with at least a first laminate of an electrically insulating material and an electrically low resistance material, which first laminate is provided on a side of the paddle facing the breast, and wherein the electrically low resistance material is sandwiched between the paddle and the insulating material.Type: GrantFiled: July 30, 2014Date of Patent: August 29, 2017Assignee: Academisch Medisch Centrum bij de Universiteit van AmsterdamInventors: Cornelis Antonius Grimbergen, Gerard Johan Den Heeten
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Patent number: 9127251Abstract: The invention provides a method for influencing the stability of an antibody producing cell, comprising directly or indirectly influencing the amount of BCL6 and/or Blimp 1 expression product within said antibody producing cell. Stable antibody producing cells and cell lines are also provided, as well as methods for producing antibodies using such cells and/or cell lines.Type: GrantFiled: December 8, 2006Date of Patent: September 8, 2015Assignees: ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM, AIMM THERAPEUTICS B.V.Inventors: Hergen Spits, Ferenc A. Scheeren, Tim Beaumont, Sean A. Diehl
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Patent number: 9050009Abstract: Mammography-apparatus for detecting malignant cells in a breast comprising an x-ray source and an x-ray detector that cooperates with the x-ray source for providing an x-ray image of said breast, and further comprising a paddle for flattening the breast by pressing it against said x-ray detector, wherein at least one sensor is applied for measuring a parameter that is used for determining the pressure at which the paddle compresses the breast, and wherein a control system is provided which controls the actuation of the paddle depending on the pressure that is applied to the breast, wherein there is a contact area measuring unit for measuring the contact area between the breast and the paddle.Type: GrantFiled: August 2, 2012Date of Patent: June 9, 2015Assignee: Academisch Medisch Centrum bij de Universiteit van AmsterdamInventors: Gerard Johan Den Heeten, Cornelis Antonius Grimbergen
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Patent number: 8981057Abstract: The invention relates to the fields of molecular biology, medicine, virology and vaccine development. Because the different forms of the presently available vaccines all have their specific drawbacks, there is a need for alternative vaccine strategies. The current invention provides means and methods for such alternative vaccine strategies.Type: GrantFiled: March 7, 2011Date of Patent: March 17, 2015Assignee: Academisch Medisch Centrum Bij De Universiteit Van AmsterdamInventor: Rogier Willem Sanders
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Patent number: 8524194Abstract: The invention is directed to radiolabelled MMP selective compounds, a processes for the preparation thereof, and uses thereof. The derivatives of the invention have formula (I) wherein Y represents O, CH2, (CH2)2, S, NH, or C(?O)NH; X represents 1-5 substituents, wherein said substituents can be the same or different and wherein at least one of said substituents comprises a radioisotope suitable for PET and/or SPECT and/or a ?-emitter; Z is S; Q is chosen from the group consisting of 3-pyridyl and carboxyl; and R is chosen from the group consisting of C(?O)—NH—OH, (II), (III, (IV). The MMP selective compounds of the invention are selective for MMPs and can be used for the identification and treatment of unstable atherosclerotic plaques.Type: GrantFiled: May 14, 2009Date of Patent: September 3, 2013Assignee: Academisch Medisch Centrum Bij de Universiteit van AmsterdamInventors: Bertha Louise Frederike Van Eck-Smit, Victorine Augustine Pinas, Albert Dirk Windhorst
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Publication number: 20130139274Abstract: The invention relates to the fields of molecular biology, medicine, virology and vaccine development. Because the different forms of the presently available vaccines all have their specific drawbacks, there is a need for alternative vaccine strategies. The current invention provides means and methods for such alternative vaccine strategies.Type: ApplicationFiled: March 7, 2011Publication date: May 30, 2013Applicant: ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAMInventor: Rogier Willem Sanders
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Publication number: 20130079384Abstract: The invention relates to medicine, in particular to internal medicine and/or cardiology. The present invention provides means and methods for typing a sample and identifying and/or treating a patient suffering from or at risk of suffering from cardiovascular disease by measuring mi RNA present in a sample of said patient. The present invention further provides means and methods for identifying new cardiovascular disease therapies.Type: ApplicationFiled: April 21, 2011Publication date: March 28, 2013Applicant: Academisch Medisch Centrum bij de Universiteit van AmsterdamInventors: Esther Elisa Johanna Maria Creemers, Sara Johanna Pinto-Sietsma
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Publication number: 20130028373Abstract: Mammography-apparatus for detecting malignant cells in a breast comprising an x-ray source and an x-ray detector that cooperates with the x-ray source for providing an x-ray image of said breast, and further comprising a paddle for flattening the breast by pressing it against said x-ray detector, wherein at least one sensor is applied for measuring a parameter that is used for determining the pressure at which the paddle compresses the breast, and wherein a control system is provided which controls the actuation of the paddle depending on the pressure that is applied to the breast, wherein there is a contact area measuring unit for measuring the contact area between the breast and the paddle.Type: ApplicationFiled: August 2, 2012Publication date: January 31, 2013Applicant: Academisch Medisch Centrum bij de Universiteit van AmsterdamInventors: Gerard Johan Den Heeten, Cornelis Antonius Grimbergen
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Publication number: 20110245666Abstract: A mammography-apparatus for detecting malignant cells in a breast comprising an X-ray source, an X-ray detector and a paddle for pressing the breast against said X-ray detector, wherein the mammography-apparatus further comprises a non-focussed laser-beam source for pulsed laser-light, which during use is aimed at the breast, and said apparatus comprises at least one non-contact ultrasound detector for contact-free detection of an ultrasound originating from said breast so as to screen the occurrence or non-occurrence of said malignant cells.Type: ApplicationFiled: April 8, 2011Publication date: October 6, 2011Applicant: Academisch Medisch Centrum bij de Universiteit van AmsterdamInventors: Gerhard Johan Den Heeten, Cornelis Antonius Grimbergen
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Patent number: 7964406Abstract: The invention provides a method for producing a stabilized cell of interest, said method comprising providing a stem cell and/or a precursor cell of said cell of interest with a nucleic acid sequence which, when present in said cell of interest, is capable of stabilizing said cell of interest, providing a non-human animal with said stem cell and/or precursor cell, allowing generation of said cell of interest in said animal, and obtaining said cell of interest. Said animal is preferably provided with a human stem cell and/or human precursor cell, allowing production of a human cell line.Type: GrantFiled: August 10, 2005Date of Patent: June 21, 2011Assignee: Academisch Medisch Centrum Bij De Universiteit Van AmsterdamInventors: Hergen Spits, Benjamin Berkhout, Jurgen E. Seppen, David M. Markusic, Kees Weijer
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Publication number: 20110077702Abstract: The invention provides means and methods for providing a cell with a spontaneous electrical activity and means and methods for increasing the depolarization rate of a cell having a spontaneous electrical activity. Means and methods are provided comprising: providing a cell with a compound capable of providing and/or increasing a pacemaker current If, and diminishing electrical coupling between said cell and surrounding cells and/or reducing the inward rectifier current IK1 of said cell, and or increasing the availability of INa at depolarized potentials, preferably using overexpression of additional sodium channels.Type: ApplicationFiled: September 27, 2010Publication date: March 31, 2011Applicant: Academisch Medisch Centrum Bij de Universiteit van AmsterdamInventors: Gerard J.J. Boink, Hanno L. Tan, Jacques De Bakker Milo Thomas
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Publication number: 20100255523Abstract: Described are methods for determining a concentration of a substance in a compartment comprising exciting an endogenous compound, or a functional part, derivative, analogue or precursor thereof, measuring the lifetime of the luminescence and/or transient absorption exhibited by the compound, functional part, derivative, analogue and/or precursor, and correlating the lifetime with the concentration of the substance.Type: ApplicationFiled: September 10, 2009Publication date: October 7, 2010Applicant: Academisch Medisch Centrum BIJ De Universiteit Van AmsterdamInventors: Egbert G. Mik, Michiel Sinaasappel
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Publication number: 20100093038Abstract: The invention provides a method for influencing the stability of an antibody producing cell, comprising directly or indirectly influencing the amount of BCL6 and/or Blimp 1 expression product within said antibody producing cell. Stable antibody producing cells and cell lines are also provided, as well as methods for producing antibodies using such cells and/or cell lines.Type: ApplicationFiled: December 9, 2005Publication date: April 15, 2010Applicants: Academisch Medisch Centrum bij de Universiteit van Amsterdam, AIMM Therapeutics B.V.Inventor: Hergen Spits