Abstract: A lower leg prosthesis, for an amputee who has at least one leg having a leg stump, has a distal end and a proximal end. The distal end is connectable to an artificial foot. The proximal end is connectable to the leg stump via a stump socket. A use condition of the lower leg prosthesis includes the distal end being connected to the artificial foot and the proximal end being connected to the leg stump via the stump socket.

Abstract: The invention relates to novel therapeutic compounds, more in particular to biologically active analogs and uses thereof as medicament, for instance for the treatment of atrial fibrillation. Provided is a compound of the general formula (formula I) wherein R1 is H or a saturated or unsaturated aliphatic moiety comprising 1 to 8 C-atoms; and X is selected from the group consisting of moieties X1, X2, X3, X4, X5 and X6. Exemplary uses include the prevention or therapeutic treatment of a HSF1-mediated disease.

Abstract: The invention relates to the field of medicine. In particular, it relates to recombinant cationic polypeptides and their use as biolubricant. Provided is a biolubricant substance comprising the amino acid sequence[(GKGVP)9]n, wherein n is ?5.

Abstract: A tracheostoma valve (1) comprises a main air passage structure provided with a main valve arrangement. The tracheostoma valve is switchable in response to a spurt of inhalation air from a breathing condition into a speaking condition, while the tracheostoma valve is switchable in response to a spurt of exhalation air from said speaking condition into said breathing condition. The main valve arrangement comprises an at least partly flexible bistable wall portion which has a circumferential bordering edge. At least part of the bordering edge forms a hinging means around which the bistable wall portion is hingeable between a first stable position in which an orifice of the main air passage structure is being blocked, and a second stable position in which said orifice is released.

Abstract: The present invention relates to methods for providing polymeric composites with bone forming, such as with osteogenic and/or osteoinductive and/or osteoconductive, properties. The present invention further relates to polymeric composites provided by the present method and the use of thereof for bone implants, or grafts, specifically the use thereof for orbital floor reconstruction. Specifically, the present invention relates to methods for providing a composite with bone forming properties, the method comprises the steps of: a) providing a liquid, or liquefied, polymeric composition of homopolymers or copolymers of 1,3-trimethylene carbonate (TMC); b) adding to said liquid, or liquefied, polymeric composition one or more agents with osteogenic and/or osteoinductive and/or osteoconductive properties thereby providing a dispersion of said agents in said liquid or liquefied polymeric composition; and c) crosslinking the product obtained, thereby providing a composite with bone forming properties.

Abstract: The invention provides a use of a substance that is capable of enhancing the amount and/or activity of DnaJB8, or a functional part, derivative and/or analogue thereof, for counteracting protein aggregation.

Abstract: A leg support instrument is designed to be fastened, in a table fastening condition, to a longitudinal side of an operating table. The instrument comprises a first frame part provided with fastening means having a table engaging portion. The instrument also comprises a second frame part with adjustable support means fastened thereto for supporting a lower leg of a person. A first hinge having a first axis of rotation connects the first frame part to the second frame part. In the table fastening condition, different distances can be set between the table engaging portion and the first axis of rotation. The instrument comprises aligning means for aligning a position of the first axis of rotation depending on a position of a person lying on the operating table. The aligning means are designed for projecting a light beam extending in line with the first axis of rotation on the lying person.

Abstract: An osseointegration system for a long bone comprises a sleeve system comprising at least two osseointegrated sleeves being mutually uncoupled in the sense that respective ones of the sleeves do not prevent one another to perform transverse displacements relative to one another; a stem arranged for being, in said operation condition, received within the at least two osseointegrated sleeves in such manner that at least low amplitude to-and-fro axial sliding displacements of the stem relative to said sleeves are allowed; at least one fitting collar; and retaining means arranged for realizing that in said operation condition the stem is retained by the long bone.

Abstract: The present invention relates to the use of a mutant TRAIL protein to treat various cancers in mammals. The invention provides a variant TRAIL protein, which has superior selectivity for the death receptor 5, for treating a mammal diagnosed with cancer.

Abstract: The invention relates to the processing of a biological sample for histological analysis. In particular, it relates to a rapid automated processing system that can be operated with continuous throughput and that eliminates the use of toxic solvents such as xylene. Provided is a method for processing a biological sample for histological analysis, comprising contacting the sample with a composition comprising a supercritical or near supercritical fluid followed by impregnating the sample under a pressure of more than 1 bar with an embedding medium, preferably paraffin.

Abstract: The invention relates to the processing of a biological sample for histological analysis. In particular, it relates to a rapid automated processing system that can be operated with continuous throughput and that eliminates the use of toxic solvents such as xylene. Provided is a method for processing a biological sample for histological analysis, comprising contacting the sample with a composition comprising a supercritical or near supercritical fluid followed by impregnating the sample under a pressure of more than 1 bar with an embedding medium, preferably paraffin.

Abstract: The carbon dioxide tension in the wall of the stomach or gastrointestinal tract is determined by inserting into the stomach a semipermeable balloon filled with a saline solution. The result obtained from analyzing the carbon dioxide fraction in the saline solution is multiplied by a correction factor to obtain a stabilized measured value for the carbon dioxide fraction relating to the blood flowing through the wall of the stomach or the gastrointestinal tract, which stabilized measured value corresponds to a measured carbon dioxide fraction pertaining to a retention time of an hour or more, and multiplying the carbon dioxide tension PaCO.sub.2 in the arterial blood with a first factor F.sub.1 to obtain a first correction product, and multiplying the stabilized value of the carbon dioxide tension PiCO.sub.2 in the blood flowing through the wall of the stomach or the gastrointestinal tract by a second factor F.sub.

Abstract: A temporomandibular joint prosthesis comprising a cranial prosthesis-part comprising a support surface adapted to be seated against bone tissue in the area of and/or adjacent to the natural glenoid fossa and/or the articular eminence and a mandibular prosthesis-part adapted to be pivotable relative to the cranial prosthesis-part when in implanted condition. The mandibular prosthesis-part is pivotable about a center of rotation which is located in such a position relative to the support surface of the cranial prosthesis-part, that in implanted condition the center of rotation is located substantially inferior to the center of the natural mandibular condyle.The prosthesis allows a natural combination of rotation and translation of the mandibular condyle in spite of the loss of the function of the lateral pterygoid muscles.