Patents Assigned to Academisch Ziekenhuis Leiden a/u Leiden University Medical Center
  • Modulation of ciliogenesis
    Patent number: 11077131
    Abstract: The disclosure is based on the finding that compounds capable of binding to (or interacting with) chromatin binding/remodelling complexes (for example Polycomb group PRC1 and Trithorax group MLL) and/or modulation of the same can be used to modulate (for example switch on/off) ciliogenesis as may occur, for example, in the human pulmonary bronchial epithelium. Provided are compounds, compositions, methods and medicaments which may be used to treat and/or prevent diseases and/or conditions associated with aberrant or defective ciliogenesis.
    Type: Grant
    Filed: November 17, 2016
    Date of Patent: August 3, 2021
    Assignee: Academisch Ziekenhuis Leiden a/u Leiden University Medical Center
    Inventor: Ronald Karel Louisa Van Brempt