Patents Assigned to Academisch Ziekenhuis Leiden H.O.D.N.
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Publication number: 20240100339Abstract: The present invention relates to a system for use in the treatment or prevention of disease or symptoms thereof, the system comprising: at least one object, wherein the object is configured for being positioned in or adjacent to the pituitary gland or the pituitary stalk of a subject; and a device configured to generate at least one intermittent stimulating signal in the object, wherein the signal subsequently activates a release of biologically active agents.Type: ApplicationFiled: February 17, 2022Publication date: March 28, 2024Applicant: Academisch Ziekenhuis Leiden (H.O.D.N. LUMC)Inventor: Wouter R. VAN FURTH
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Publication number: 20230398081Abstract: The invention relates to an extrusion additive manufacturing method for forming a drug delivery device. The method includes providing a first drug delivery material containing a first major excipient with a first melting range and a first melting peak. The method further includes extruding the first delivery material at an extrusion temperature that is within the melting range of the first major excipient.Type: ApplicationFiled: October 22, 2021Publication date: December 14, 2023Applicants: DOSER IP B.V., ACADEMISCH ZIEKENHUIS LEIDEN H.O.D.N. LUMCInventors: Niels OUWERKERK, Kirsten Johanna Maria SCHIMMEL
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Publication number: 20230390558Abstract: The present invention relates to a system, its catheter and its method for providing electrical pulses and/or therapeutic or diagnostic liquids directly to a pituitary gland of a mammal. The catheter, containing an electrode or a microcannula or both, is moved through an endovascular route of a patient to his/her sinus cavernosus and then the distal end of the electrode or microcannula is moved through an opening in the distal end of the catheter and then through a perforation in the medial wall of the sinus cavernosus, to the pituitary gland.Type: ApplicationFiled: August 23, 2023Publication date: December 7, 2023Applicant: ACADEMISCH ZIEKENHUIS LEIDEN (H.O.D.N. LUMC)Inventors: Wouter R. VAN FURTH, Nienke R. BIERMASZ, Amir H. ZAMANIPOOR NAJAFABADI
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Patent number: 11820734Abstract: This invention relates to compounds that are useful as inhibitors, in particular as inhibitors of Cathepsin K (CatK), and to a method of inhibiting cathepsin activity, comprising administering a compound or formulation comprising a compound according to the invention.Type: GrantFiled: October 20, 2021Date of Patent: November 21, 2023Assignee: ACADEMISCH ZIEKENHUIS LEIDEN (H.O.D.N. LUMC)Inventors: Huib Ovaa, Maria Wilhelmina Elisabeth Mons, Stan Van Boeckel
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Patent number: 11771897Abstract: The present invention relates to a system, its catheter and its method for providing electrical pulses and/or therapeutic or diagnostic liquids directly to a pituitary gland of a mammal. The catheter, containing an electrode or a microcannula or both, is moved through an endovascular route of a patient to his/her sinus cavernosus and then the distal end of the electrode or microcannula is moved through an opening in the distal end of the catheter and then through a perforation in the medial wall of the sinus cavernosus, to the pituitary gland.Type: GrantFiled: November 14, 2018Date of Patent: October 3, 2023Assignee: ACADEMISCH ZIEKENHUIS LEIDEN (H.O.D.N. LUMC)Inventors: Wouter R. Van Furth, Nienke R. Biermasz, Amir H. Zamanipoor Najafabadi
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Publication number: 20230256075Abstract: The present invention relates to novel CD4+ and CD8+ T cell epitopes that are specific for HPV-specific E6 and E7 oncoproteins, to peptides comprising these novel T cell epitopes, and to (vaccine) compositions comprising these peptides for use in methods for the prevention and/or treatment of HPV related diseases. Preferred epitopes are recognized by a T cell that infiltrates a cervical neoplastic lesion or by a T cell from a draining lymph node, and are presented by an HLA-DQ or HLA-DP molecule, or an HLA-B.Type: ApplicationFiled: September 19, 2022Publication date: August 17, 2023Applicant: Academisch Ziekenhuis Leiden H.O.D.N. LUMCInventors: Sjoerd Henricus VAN DER BURG, Gemma G. KENTER, Cornelis Johannes Maria MELIEF
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Patent number: 11680088Abstract: The disclosure concerns snake-derived peptides and the useful application of such peptides to inhibit bacterial, fungal, viral and parasitic infections. The disclosed peptides are also useful for the treatment of an inflammatory condition or cancers.Type: GrantFiled: September 17, 2019Date of Patent: June 20, 2023Assignees: Universiteit Leiden, Academisch Ziekenhuis Leiden h.o.d.n. LUMCInventors: Harald Martijn Ijsbrand Kerkkamp, Michael Keith Richardson, Gilles Philippus van Wezel, Jan Wouter Drijfhout, Robert Alexander Cordfunke, Michella Manon Voet, Petrus Hendricus Nibbering
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Patent number: 11661602Abstract: The invention relates to antisense molecules and methods for modulating splicing of polyomavirus T antigen pre-mRNA. In one aspect the invention relates to an antisense oligonucleotide 12 to 30, preferably 17, 18, 19 or 20 to 30 nucleobases in length which comprises a sequence that is the reverse complement of a contiguous stretch of at least 12 nucleobases of a polyomavirus T-antigen pre-mRNA and which antisense oligonucleotide can modulate splicing of said T-antigen pre-mRNA in a cell.Type: GrantFiled: March 1, 2019Date of Patent: May 30, 2023Assignee: ACADEMISCH ZIEKENHUIS LEIDEN H.O.D.N. LUMCInventors: Eric Peter Van Der Veer, Anton Jan Van Zonneveld, Jurriën Prins
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Publication number: 20230075084Abstract: The present invention relates to an automated stimulation device for inducing a tactile inter-stimulus onset asynchrony (ISOA) effect in a subject suffering from apnea, bradycardia and/or hypoxia, the device comprising at least two actuators configured for contacting a body portion of the subject, and interspaced for producing an apparent tactile movement in the subject upon sequential induction of actuation, wherein the duration of the actuations and the overlap in actuation time between the at least two actuators is controlled to attain an inter stimulus onset asynchrony (ISOA).Type: ApplicationFiled: February 15, 2021Publication date: March 9, 2023Applicant: ACADEMISCH ZIEKENHUIS LEIDEN (H.O.D.N. LUMC)Inventors: Arjan Benedictus Te Pas, Sophie Josephine Elisabeth Cramer, Stuart Brian Hooper
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Patent number: 11525140Abstract: The present disclosure provides methods for transfecting plants and for expressing RNA or polypeptide molecules in plants. In particular, plants having reduced POLQ expression and/or activity are transfected in order to reduce random integration events. The disclosure further provides transfected plants and plant progeny produced by the methods disclosed herein.Type: GrantFiled: March 23, 2017Date of Patent: December 13, 2022Assignees: UNIVERSITEIT LEIDEN, ACADEMISCH ZIEKENHUIS LEIDEN H.O.D.N. LUMCInventors: Marcel Tijsterman, Maartje Van Kregten, Paul Hooykaas
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Publication number: 20220305102Abstract: Novel nucleic acid sequences, vectors, modified cells, peptides and pharmaceutical compositions are provided that are useful in the treatment of human subjects having a ?NPM1 positive haematological malignancy. Corresponding methods and uses are also provided.Type: ApplicationFiled: May 13, 2022Publication date: September 29, 2022Applicant: ACADEMISCH ZIEKENHUIS LEIDEN (H.O.D.N. LEIDS UNIVERSITAIR MEDISCH CENTRUM)Inventors: Marieke GRIFFIOEN, J. H. Frederik FALKENBURG
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Publication number: 20220227705Abstract: This invention relates to compounds that are useful as inhibitors, in particular as inhibitors of Cathepsin K (CatK), and to a method of inhibiting cathepsin activity, comprising administering a compound or formulation comprising a compound according to the invention.Type: ApplicationFiled: October 20, 2021Publication date: July 21, 2022Applicant: ACADEMISCH ZIEKENHUIS LEIDEN (H.O.D.N. LUMC)Inventors: Huib OVAA, Maria Wilhelmina Elisabeth MONS, Stan VAN BOECKEL
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Patent number: 11352389Abstract: Novel nucleic acid sequences, vectors, modified cells, peptides and pharmaceutical compositions are provided that are useful in the treatment of human subjects having a ?NPM1 positive haematological malignancy. Corresponding methods and uses are also provided.Type: GrantFiled: June 28, 2018Date of Patent: June 7, 2022Assignee: Academisch Ziekenhuis Leiden (h.o.d.n. Leids Universitair Medisch Centrum)Inventors: Marieke Griffioen, J. H. Frederik Falkenburg
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Publication number: 20220087981Abstract: The present invention relates to active agents or compounds as well as pharmaceutical compositions comprising said compounds, which are capable of reducing or inhibiting or blocking the enzymatic activity of the glutaminyl-peptide cyclotransferase (QPCT) protein, the glutaminyl-peptide cyclotransferase-like protein (QPCTL) protein, or combinations thereof or are capable of reducing or inhibiting the expression of QPCT gene, the QPCTL gene, or combinations thereof. Also provided are methods for screening or selecting for said compounds. The present invention further relates to a pharmaceutical composition comprising a first active agent for use in a method of treating a condition in a subject that would benefit from reducing the signaling or the binding between SIRP? and CD47 in the subject (e.g. cancer), wherein the method of treating comprises reducing expression or enzymatic activity of QPCTL, QPCT, or combinations thereof in the cell with CD47 on the surface.Type: ApplicationFiled: April 23, 2021Publication date: March 24, 2022Applicants: Stichting Het Nederlands Kanker Instituut-Antoni Van Leeuwenhoek Ziekenhuis, Academisch Ziekenhuis Leiden H.O.D. N. LUMCInventors: Matthijs Raaben, Ferenc Alexander Scheeren, Meike Emma Willemijn Logtenberg, Thijn Reinout Brummelkamp, Antonius Nicolaas Maria Schumacher, Jeannette Henrica Wilhelmina Leusen
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Patent number: 11246947Abstract: The present invention relates to a Crumbs homologue (CRB) therapeutic for use as a medicament or in a method of treatment or prophylaxis, for example in the treatment or prophylaxis of a retinal disorder due to mutations in the Crumbs homologue-1 (CRB1) gene, such as Leber's congenital amaurosis 8 (LCA8) or retinitis pigmentosa 12 (RP12). In particular, the present invention relates to a recombinant viral vector comprising CRB2 or modified non-toxic forms of either CRB1 or CRB3 that resemble CRB2.Type: GrantFiled: August 5, 2014Date of Patent: February 15, 2022Assignee: Academisch Ziekenhuis Leiden H.O.D. N. Leids Universitair Medisch CentrumInventors: Jan Wijnholds, Lucie Pierrette Francoise Pellissier
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Patent number: 11174224Abstract: This invention relates to compounds that are useful as inhibitors, in particular as inhibitors of Cathepsin K (CatK), and to a method of inhibiting cathepsin activity, comprising administering a compound or formulation comprising a compound according to the invention.Type: GrantFiled: December 5, 2018Date of Patent: November 16, 2021Assignee: ACADEMISCH ZIEKENHUIS LEIDEN (H.O.D.N. LUMC)Inventors: Huib Ovaa, Maria Wilhelmina Elisabeth Mons, Stan Van Boeckel
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Publication number: 20210085809Abstract: The present invention relates to a vaccine composition for use in in vivo administration, comprising a (attenuated) pathogen or commensal modified to be a pre-targeting vector, the pre-targeting vector comprising one or more pendent reactive moieties able to form a high affinity interaction with a complementary moiety residing on an immunogenic conjugate component.Type: ApplicationFiled: July 27, 2018Publication date: March 25, 2021Applicant: ACADEMISCH ZIEKENHUIS LEIDEN (h.o.d.n. LUMC)Inventors: Fijs W. B. VAN LEEUWEN, Meta ROESTENBERG
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Publication number: 20200385341Abstract: This invention relates to compounds that are useful as inhibitors, in particular as inhibitors of Cathepsin K (CatK), and to a method of inhibiting cathepsin activity, comprising administering a compound or formulation comprising a compound according to the invention.Type: ApplicationFiled: December 5, 2018Publication date: December 10, 2020Applicant: ACADEMISCH ZIEKENHUIS LEIDEN (H.O.D.N. LUMC)Inventors: Huib OVAA, Maria Wilhelmina Elisabeth MONS, Stan VAN BOECKEL
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Publication number: 20200378968Abstract: The present invention relates to a method for labeling or targeting cells whose plasma membrane has lost integrity, such as dead cells, such as for discriminating between live cells and cells whose plasma membrane has lost integrity; to an embodiment of the method for determining one or more values of one or more parameters of cells of a biological sample; to use of the method in an assay for screening drugs for therapy such as cancer therapy; to use of the method to monitor and/or determine the effectiveness of a therapy; to an assay kit; to a complex; to the complex for use as a medicament; to the complex for use in treatment of cancer(s) and/or plaque(s) and/or regeneration and/or supporting the immune system; and, to a dead cell.Type: ApplicationFiled: April 10, 2020Publication date: December 3, 2020Applicants: HQ Medical Netherlands B.V., Publiekrechtelijk rechtspersoon Academisch Ziekenhuis Leiden h.o.d.n. LUMCInventors: Markwin Hendrik Maring, Clemens Waltherus Gerardus Löwik, Ermond Reijer Van Beek
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Publication number: 20200289640Abstract: The present invention relates to novel CD4+ and CD8+ T cell epitopes that are specific for HPV-specific E6 and E7 oncoproteins, to peptides comprising these novel T cell epitopes, and to (vaccine) compositions comprising these peptides for use in methods for the prevention and/or treatment of HPV related diseases. Preferred epitopes are recognized by a T cell that infiltrates a cervical neoplastic lesion or by a T cell from a draining lymph node, and are presented by an HLA-DQ or HLA-DP molecule, or an HLA-B.Type: ApplicationFiled: May 27, 2020Publication date: September 17, 2020Applicant: Academisch Ziekenhuis Leiden H.O.D.N. LUMCInventors: Sjoerd Henricus Van Der Burg, Gemma G. Kenter, Cornelis Johannes Maria Melief