Abstract: The invention provides a method for influencing the stability of an antibody producing cell, comprising directly or indirectly influencing the amount of BCL6 and/or Blimp 1 expression product within said antibody producing cell. Stable antibody producing cells and cell lines are also provided, as well as methods for producing antibodies using such cells and/or cell lines.
Type:
Grant
Filed:
December 9, 2005
Date of Patent:
April 14, 2015
Assignees:
Academish Medisch Centrum Bij de Universiteit van Amsterdam, AIMM Therapeutics B.V.