Patents Assigned to ACADEMY OF MILITARY MEDICAL SCIENCES
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Publication number: 20210220353Abstract: The present application relates to a Favipiravir compound represented by Formula I, a geometric isomer, a pharmaceutically acceptable salt, a solvate and/or a hydrate thereof, and a pharmaceutical composition comprising the compound for treating a coronavirus infection.Type: ApplicationFiled: October 14, 2020Publication date: July 22, 2021Applicant: Academy of Military Medical SciencesInventors: Wu ZHONG, Ruiyuan CAO, Cheng CAO, Ting GAO, Gengfu XIAO, Zhihong HU, Manli WANG, Leike ZHANG, Song LI
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Patent number: 11066441Abstract: The present invention discloses a method for separating and purifying ?2-macroglobulin from Cohn Fraction IV precipitation, in which Cohn Fraction IV precipitation is treated by ammonium sulfate precipitation, zinc ion affinity chromatography, gel filtration, and ultrafiltration and concentration sequentially and thereby ?2-macroglobulin is obtained finally. With the method provided in the present invention, purified ?2-macroglobulin plasma protein that has a clinical application value is obtained, the Cohn Fraction IV precipitation is changed from a discarded material into a valuable material, and plasma is utilized comprehensively. In addition, the method is easy and simple to use, easy to scale up, and suitable for separation and purification of ?2-macroglobulin at a large scale.Type: GrantFiled: September 14, 2016Date of Patent: July 20, 2021Assignee: ACADEMY OF MILITARY MEDICAL SCIENCESInventors: Yuyuan Ma, Chaoji Huangfu, Xiong Zhao, Maomin LV, Jingang Zhang, Junting Jia
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Patent number: 10981873Abstract: Disclosed are a nicotinic acid or isonicotinic acid compound and a use thereof. The compound is the compound shown in Formula I, or a pharmaceutically acceptable salt, ester or solvate thereof. Efficacy tests demonstrate that the nicotinic acid compound can inhibit botulinum toxin endopeptidase activity in vitro, and has a significant protective effect on mice poisoned with botulinum toxin. On this basis, the compound may be used to prepare a drug preventing and/or treating botulinum toxin exposure and/or poisoning.Type: GrantFiled: September 8, 2017Date of Patent: April 20, 2021Assignee: ACADEMY OF MILITARY MEDICAL SCIENCESInventors: Hui Wang, Tao Li, Zhenyuan Miao, Jianxin Wang, Deyan Luo, Jie Huang, Chunlin Zhuang, Yuelin Wu
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Patent number: 10889575Abstract: The invention belongs to the field of medicine and chemical industry and relates to a 4,4-diphenylpiperidine compound or a pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising the same and uses thereof. In particular, the invention relates to a compound of Formula I or a pharmaceutically acceptable salt thereof, and to a pharmaceutical composition comprising the compound or a pharmaceutically acceptable salt thereof. In the present invention, the compound or pharmaceutically acceptable salt thereof and the pharmaceutical composition have significant activity in blocking an N-type calcium channel, and have good pharmacokinetic properties, can effectively relieve pain, and have a potential as a new medicament for prevention or treatment of pain, stroke, cerebral ischemia, alcohol addiction, alcoholism, kidney disease, addictive disorder caused by analgesic or tolerance disorder caused by analgesic.Type: GrantFiled: January 12, 2018Date of Patent: January 12, 2021Assignee: Academy of Military Medical SciencesInventors: Cheng Zhang, Haoshan Wang, Guoxing Dong, Ning Wu, Shuzhuo Zhang, Xiaomei Zhuang, Chong Pang, Juan Wang, Rifang Yang, Jianquan Zheng, Jin Li, Liuhong Yun
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Publication number: 20200392188Abstract: The present invention relates to a nucleotide sequence as shown in SEQ ID NO: 1 for encoding a Marburg virus envelope glycoprotein, and to a human replication-deficient recombinant adenovirus capable of expressing the nucleotide sequence and a preparation method therefor, as well as an application thereof in the preparation of a vaccine against Marburg virus disease. The vaccine uses an E1 and E3 deleted replication-deficient human type-5 adenovirus as a vector, and HEK293 cells integrating an adenovirus E1 gene as a packaging cell line, and a protective antigen gene carried is a codon-optimized Marburg virus Angola strain envelope glycoprotein gene. After codon optimization of the envelope glycoprotein gene, significant expression of envelope glycoprotein can be detected in transfected cells.Type: ApplicationFiled: August 27, 2018Publication date: December 17, 2020Applicant: Academy of Military Medical Science, PLAInventors: Wei Chen, Shipo Wu, Lihua Hou, Yanbo Wen, Zhe Zhang, Busen Wang, Xiaohong Song, Jinlong Zhang, Ling Fu
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Patent number: 10844098Abstract: The invention provided a method for preparing a bacterial polysaccharide-modified recombinant fusion protein and use of the bacterial polysaccharide-modified recombinant fusion protein. The method comprises: co-expressing a recombinant fusion protein and the Neisseria meningitidis O-oligosaccharyltransferase PglL in an O-antigen ligase gene-defective bacterium, and linking a polysaccharides endogenous or exogenous for the bacterium to the recombinant fusion protein by the O-oligosaccharyltransferase PglL, to obtain the bacterial polysaccharide-modified recombinant fusion protein. The protein can be used for preparing antibodies against bacterial polysaccharides and vaccines.Type: GrantFiled: September 1, 2015Date of Patent: November 24, 2020Assignee: Institute of Biotechnology, Academy of Military Medical Sciences, ChinaInventors: Jun Wu, Chao Pan, Peng Sun, Hengliang Wang, Bo Liu, Zhehui Peng, Li Zhu, Shaohong Chang, Xin Gong, Erling Feng, Bin Wang, Ming Zeng
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Patent number: 10786481Abstract: Disclosed are hydroquinone compounds, preparation methods therefor, and uses thereof in anti-tumor or immunomodulation. The structural formula of the hydroquinone compounds are shown by formula I, wherein X is C?O or CH2; Y is NH, O or absent; R is a substituted or unsubstituted alkyl group having at least one carbon atom, a substituted or unsubstituted cycloalkyl group having at least three carbon atoms, a substituted or unsubstituted alkenyl group or alkynyl group having at least two carbon atoms; and a substituted or unsubstituted aryl group or heteroaryl group containing at least four carbon atoms. The compounds provided slowly release 2-tert-butyl-4-methoxyphenol in vivo and maintain stable plasma concentration of 2-tert-butyl-4-methoxyphenol (T½=12˜24 h). The compounds provided by the present invention protect the phenolic hydroxyl group of 2-tert-butyl-4-methoxyphenol, avoid environmental oxidation and increase the environmental stability of drugs containing the compounds.Type: GrantFiled: February 22, 2017Date of Patent: September 29, 2020Assignees: BIOMEDICAL ANAYLSIS CENTER, ACADEMY OF MILITARY MEDICAL SCIENCES, INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY, ACADEMY OF MILITARY MEDICAL SCIENCESInventors: Xuemin Zhang, Xinhua He, Tao Zhou, Zhenggang Liu, Tao Li
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Patent number: 10780154Abstract: The present invention discloses a Salmonella paratyphi A with an O-antigen having an extended carbohydrate chain and uses thereof. The method comprises the following steps: inactivating an cld gene encoding an enzyme controlling chain length of O-antigen of a Salmonella paratyphi A strain to obtain a Salmonella paratyphi A with deletion of cld gene; allowing overexpression of cldLT2 gene encoding an enzyme controlling chain length of O-antigen of Salmonella typhimurium in Salmonella paratyphi A deficient in the cld gene encoding an enzyme controlling chain length of O-antigen, so as to extend carbohydrate chain length of O-antigen. Both of the Salmonella paratyphi A O-polysaccharide-recombinant fusion protein conjugate vaccines rCTB45733-OPSSpty50973 and rEPA4573-OPSSpty50973 as prepared by using Salmonella paratyphi A with an O-antigen having an extended carbohydrate chain can induce mice to generate specific antibodies against Salmonella paratyphi A, and their antibody titers are significantly improved.Type: GrantFiled: September 7, 2015Date of Patent: September 22, 2020Assignee: Institute of Biotechnology, Academy of Military Medical Sciences, ChinaInventors: Jun Wu, Hengliang Wang, Peng Sun, Bo Liu, Li Zhu, Chao Pan, Tiantian Wang, Xin Gong, Shaohong Chang, Erling Feng
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Patent number: 10759822Abstract: Disclosed in the present invention is a compound of Formula (I), a geometric or optical isomer, a pharmaceutically acceptable salt, a solvate or a polymorph thereof. Also disclosed in the present invention is a composition comprising the compound of Formula (I), the geometric or optical isomer, the pharmaceutically acceptable salt, the solvate or the polymorph thereof. Also disclosed in the present invention is a use of the compound of Formula (I), the geometric or optical isomer, the pharmaceutically acceptable salt, the solvate or the polymorph thereof in the treatment of a disease or disorder such as a hypoglutamatergic condition, a neurodegenerative disease or respiratory depression, particularly in the treatment of a disease or disorder associated with AMPA receptor.Type: GrantFiled: April 11, 2017Date of Patent: September 1, 2020Assignee: Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. ChinaInventors: Song Li, Xinbo Zhou, Dian Xiao, Wu Zhong, Junhai Xiao, Zhibing Zheng, Xingzhou Li, Yunde Xie, Xiaokui Wang
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Patent number: 10709777Abstract: The present invention discloses a Salmonella paratyphi A with an O-antigen having an extended carbohydrate chain and uses thereof. The method comprises the following steps: inactivating an cld gene encoding an enzyme controlling chain length of O-antigen of a Salmonella paratyphi A strain to obtain a Salmonella paratyphi A with deletion of cld gene; allowing overexpression of cldLT2 gene encoding an enzyme controlling chain length of O-antigen of Salmonella typhimurium in Salmonella paratyphi A deficient in the cld gene encoding an enzyme controlling chain length of O-antigen, so as to extend carbohydrate chain length of O-antigen. Both of the Salmonella paratyphi A O-polysaccharide-recombinant fusion protein conjugate vaccines rCTB45733-OPSSpty50973 and rEPA4573-OPSSpty50973 as prepared by using Salmonella paratyphi A with an O-antigen having an extended carbohydrate chain can induce mice to generate specific antibodies against Salmonella paratyphi A, and their antibody titers are significantly improved.Type: GrantFiled: September 7, 2015Date of Patent: July 14, 2020Assignee: Institute of Biotechnology, Academy of Military Medical Sciences, ChinaInventors: Jun Wu, Peng Sun, Bo Liu, Shaohong Chang, Xin Gong, Hengliang Wang, Li Zhu, Chao Pan, Erling Feng
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Patent number: 10705005Abstract: The present invention discloses a unit for validating an in situ decontamination effect, including a connecting end. A left end of the connecting end is in communication with any space that needs gas decontamination. A right end of the connecting end is connected to a closed isolation damper. A right end of the closed isolation damper is connected to a hollow decontamination validation chamber. A sealing cover is sleeved over an outer wall of the decontamination validation chamber. A mesh cup is placed inside the decontamination validation chamber, and the mesh cup is used for placing a bioindicator. In addition, the present invention further discloses a device for filtering biologically contaminated air, including a unit for validating an in situ decontamination effect and a hollow box installed with a high efficiency particulate air (HEPA) filter. The unit for validating an in situ decontamination effect is in communication with the hollow box.Type: GrantFiled: March 9, 2018Date of Patent: July 7, 2020Assignee: Institute of Medical Equipment, Academy of Military Medical Sciences, PLAInventors: Jiancheng Qi, Zongxing Zhang, Ying Yi, Jinhui Wu
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Patent number: 10697022Abstract: Disclosed is a kit for detecting drug resistance of cetuximab in the treatment of metastatic colorectal cancer. The kit comprises a substance used for detecting gene mutations in Exon 19 of the PIK3CA gene, and may further comprise a specification recording the following contents: if Exon 19 in the PIK3CA gene of a patient with metastatic colorectal cancer as a subject to be tested, who is intended to receive cetuximab treatment or is receiving cetuximab treatment and does not have drug resistance, has at least one of K944N, F930S, V955G, V955I, and K966E mutations, the subject to be tested will develop drug resistance or will be a candidate to develop drug resistance when receiving or continuing to receive cetuximab for treating metastatic colorectal cancer.Type: GrantFiled: November 6, 2015Date of Patent: June 30, 2020Assignee: AFFILIATED HOSPITAL, ACADEMY OF MILITARY MEDICAL SCIENCESInventors: Jianming Xu, Yan Wang, Yan Wang
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Patent number: 10647690Abstract: The present invention relates to a 2,3-epoxy succinyl derivative, a preparation method and a use thereof, in particular, the present invention relates to a compound represented by Formula (1), a racemate or an optical isomer thereof, a solvate thereof, or a pharmaceutically acceptable salt thereof. The compound according to the present invention has good inhibitory activity and/or selectivity against cathepsin, especially Cathepsin B, can be used in the treatment of multiple diseases associated with cathepsin, for example, osteoporosis, rheumatoid arthritis and osteoarthritis that are associated with Cathepsin K, Ebola virus infection, a degenerative disease and an autoimmune disease that are associated with Cathepsin L, S, especially Cathepsin B-related tumor diseases, such as gastric cancer, cervical cancer, lung cancer, breast cancer, prostate cancer, bladder cancer, colon cancer, neuroglioma, and melanoma.Type: GrantFiled: March 2, 2017Date of Patent: May 12, 2020Assignee: Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. ChinaInventors: Song Li, Junhai Xiao, Xiaoye Zhang, Hongliang Wang, Wu Zhong, Zhibing Zheng, Yunde Xie, Xingzhou Li, Xinbo Zhou, Xiaokui Wang
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Patent number: 10611742Abstract: The present invention relates to a compound represented by Formula I, a racemate or optical isomer thereof, or a pharmaceutically acceptable salt, a solvate or a hydrate thereof, a pharmaceutical composition comprising the compound, and a use thereof in the manufacture of a medicament for preventing and/or treating a disease or disorder associated with a viral infection.Type: GrantFiled: November 24, 2016Date of Patent: April 7, 2020Assignee: Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. ChinaInventors: Song Li, Junhai Xiao, Libao Xu, Ruiyuan Cao, Fangyuan Cao, Hongliang Wang, Wu Zhong, Zhibing Zheng, Yunde Xie, Xingzhou Li, Xinbo Zhou, Xiaokui Wang
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Publication number: 20190358203Abstract: The present invention relates to a pharmaceutical composition, comprising Tecovirimat, cyclodextrin and an additive, and optionally a pharmaceutically acceptable excipient. The present invention also relates to a method for preparing the pharmaceutical composition. The composition improves the solubility of Tecovirimat in water by using cyclodextrin and meglumine in combination, as compared with the solubility of Tecovirimat in water by using cyclodextrin or meglumine alone.Type: ApplicationFiled: July 4, 2017Publication date: November 28, 2019Applicant: Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L..A. ChinaInventors: Wu ZHONG, Meiyan YANG, Wei GONG, Yuli WANG, Chunsheng GAO, Xinbo ZHOU, Song LI
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Publication number: 20190359604Abstract: The invention belongs to the field of medicine and chemical industry and relates to a 4,4-diphenylpiperidine compound or a pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising the same and uses thereof. In particular, the invention relates to a compound of Formula I or a pharmaceutically acceptable salt thereof, and to a pharmaceutical composition comprising the compound or a pharmaceutically acceptable salt thereof. In the present invention, the compound or pharmaceutically acceptable salt thereof and the pharmaceutical composition have significant activity in blocking an N-type calcium channel, and have good pharmacokinetic properties, can effectively relieve pain, and have a potentialas a new medicament for prevention or treatment of pain, stroke, cerebral ischemia, alcohol addiction, alcoholism, kidney disease, addictive disorder caused by analgesic or tolerance disorder caused by analgesic.Type: ApplicationFiled: January 12, 2018Publication date: November 28, 2019Applicant: Academy of Military Medical SciencesInventors: Cheng Zhang, Haoshan WANG, Guoxing DONG, Ning WU, Shuzhuo ZHANG, Xiaomei ZHUANG, Chong PANG, Juan WANG, Rifang YANG, Jianquan ZHENG, Jin LI, Liuhong YUN
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Patent number: 10450358Abstract: Provided are a platelet-derived growth factor B derivative, the encoding nucleic acid molecule thereof, and a vector and host cell having the nucleic acid molecule. Also provided are a preparation method for the mutant, and the use of the mutant in preparing medications for promoting cell division, cell proliferation, wound healing, skin regeneration, bone and tooth defect regeneration, and joint repair.Type: GrantFiled: July 16, 2015Date of Patent: October 22, 2019Assignee: Institute of Biotechnology Academy of Military Medical Sciences P.L.A. ChinaInventors: Wei Chen, Xiaopeng Zhang, Changming Yu, Ling Fu, Mengmeng Dai, Jun Zhang, Junjie Xu, Lihua Hou, Jianmin Li
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Publication number: 20190241522Abstract: Disclosed are a nicotinic acid or isonicotinic acid compound and a use thereof. The compound is the compound shown in Formula I, or a pharmaceutically acceptable salt, ester or solvate thereof. Efficacy tests demonstrate that the nicotinic acid compound can inhibit botulinum toxin endopeptidase activity in vitro, and has a significant protective effect on mice poisoned with botulinum toxin. On this basis, the compound may be used to prepare a drug preventing and/or treating botulinum toxin exposure and/or poisoning.Type: ApplicationFiled: September 8, 2017Publication date: August 8, 2019Applicant: Academy of Military Medical SciencesInventors: Hui WANG, Tao LI, Zhenyuan MIAO, Jianxin WANG, Deyan LUO, Jie HUANG, Chunlin ZHUANG, Yuelin WU
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Publication number: 20190233383Abstract: The present invention pertains to field of pharmaceutical chemicals, and relates to thiazole inner salt compounds, preparation methods and uses thereof. Specifically, the present invention relates to a compound of Formula I, hydrates or pharmaceutically acceptable salts thereof. The compound of Formula I of the present invention is a potent cross-linking protein cleavage agent, has a stable structure, good physical and chemical properties, and good pharmacological activities, and is suitable for large scale production to obtain samples with stable, controllable and reliable quality, thereby being suitable for pharmaceutical development.Type: ApplicationFiled: April 12, 2019Publication date: August 1, 2019Applicant: Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. ChinaInventors: Song LI, Wu ZHONG, Shuang CAO, Lili WANG, Zhibing ZHENG, Junhai XIAO, Xinbo ZHOU
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Patent number: 10335417Abstract: The invention belongs to the technical field of medicines. In particular, the invention relates to a thiazideamide derivative compound or a pharmaceutically acceptable salt or solvate thereof, a pharmaceutical composition comprising the compound or a pharmaceutically acceptable salt or solvate thereof, a method for preparing the compound or a pharmaceutically acceptable salt or solvate thereof, and a use of the compound or a pharmaceutically acceptable salt or solvate thereof. For example, the compound or a pharmaceutically acceptable salt or solvate thereof according to the invention can be used to prevent and/or treat a neurodegenerative disease or a neuropathic disease caused by a physical trauma or a related disease.Type: GrantFiled: June 28, 2016Date of Patent: July 2, 2019Assignee: Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. ChinaInventors: Song Li, Junhai Xiao, Boqun Lyu, Hongqiang Wang, Wu Zhong, Lili Wang, Zhibing Zheng, Yunde Xie, Xinbo Zhou, Xingzhou Li, Xiaokui Wang