Patents Assigned to Acadia Pharmacueticals Inc.
  • Methods of identifying inverse agonists of the serotonin 2A receptor
    Patent number: 6358698
    Abstract: The present invention relates to a method of identifying compounds which act as inverse agonists of the 5-HT2A receptor, the method comprising contacting a constitutively active 5-HT2A receptor with at least one test compound and determining any decrease in the level of basal activity of the receptor so as to identify a test compound which is an inverse agonist of the 5-HT2A receptor. Such inverse agonists may be used in the treatment of schizophrenia and related psychoses.
    Type: Grant
    Filed: October 6, 1999
    Date of Patent: March 19, 2002
    Assignee: Acadia Pharmacueticals Inc.
    Inventors: David Weiner, Mark R. Brann