Patents Assigned to Acambis Inc.
  • Patent number: 7569383
    Abstract: The invention provides chimeric flavivirus vectors including foreign peptides inserted into the envelope proteins of the vectors and methods of using these vectors.
    Type: Grant
    Filed: May 31, 2002
    Date of Patent: August 4, 2009
    Assignee: Acambis Inc.
    Inventors: Harold Kleanthous, Charles Miller, Larisa Oros
  • Patent number: 7507415
    Abstract: The invention provides chimeric flavivirus vaccines against West Nile virus and methods of using these vaccines to prevent or treat West Nile virus infection.
    Type: Grant
    Filed: November 17, 2003
    Date of Patent: March 24, 2009
    Assignee: Acambis Inc.
    Inventors: Juan Arroyo, Charles Miller, John Avram Catalan, Thomas P. Monath
  • Patent number: 7459160
    Abstract: The invention provides flavivirus vaccines and methods of making and using these vaccines.
    Type: Grant
    Filed: January 15, 2003
    Date of Patent: December 2, 2008
    Assignee: Acambis Inc.
    Inventors: Thomas P. Monath, Farshad Guirakhoo, Juan Arroyo, Konstantin Pugachev
  • Publication number: 20080193477
    Abstract: This invention relates to methods and kits for use in vaccination against dengue virus infection.
    Type: Application
    Filed: August 9, 2006
    Publication date: August 14, 2008
    Applicants: Acambis Inc., Sanofi Pasteur SA
    Inventors: Thomas P. Monath, Farshad Guirakhoo, Niranjan Kanesa-thasan, Thomas H. Ermak, Jean Lang, Remi Forrat
  • Publication number: 20080175862
    Abstract: The invention provides recombinant flavivirus vaccines that can be used in the prevention and treatment of flavivirus infection. The vaccines of the invention contain recombinant flaviviruses including attenuating mutations.
    Type: Application
    Filed: April 24, 2006
    Publication date: July 24, 2008
    Applicant: Acambis Inc.
    Inventors: Konstantin V. Pugachev, Farshad Guirakhoo, Thomas P. Monath
  • Patent number: 7361352
    Abstract: A chimeric, carboxy-terminal truncated hepatitis B virus nucleocapsid (HBc) protein is disclosed that contains an immunogen for inducing the production of antibodies to the influenza M2 protein. An immunogenic influenza sequence in two to four copies is preferably expressed at or near the N-terminus or in the HBc immunogenic loop sequence. The HBc chimer preferably contains an influenza-specific T cell epitope and is preferably engineered for both enhanced stability of self-assembled particles and enhanced yield of those chimeric particles. Methods of making and using the chimers are also disclosed.
    Type: Grant
    Filed: February 26, 2004
    Date of Patent: April 22, 2008
    Assignees: Acambis, Inc., Vlaams Interuniversitair Institutuut voor Biotechnologie
    Inventors: Ashley J. Birkett, Walter Fiers
  • Publication number: 20070269458
    Abstract: The invention provides attenuated Flavivirus vaccines, such as vaccines against Japanese encephalitis virus and West Nile virus, as well as methods of making and using these vaccines.
    Type: Application
    Filed: October 19, 2005
    Publication date: November 22, 2007
    Applicant: Acambis Inc.
    Inventors: Farshad Guirakhoo, Jian Liu, John Catalan, Thomas Monath, Konstantin Pugachev
  • Publication number: 20070231336
    Abstract: The invention provides active and passive immunization methods for preventing and treating Clostridium difficile infection, which involve percutaneous administration of C. difficile toxin-neutralizing polyclonal immune globulin, C. difficile toxoids, or combinations thereof. Also provided by the invention are C. difficile toxoids, C. difficile toxin-neutralizing polyclonal immune globulin, and methods of identifying subjects that produce C. difficile toxin-neutralizing polyclonal immune globulin.
    Type: Application
    Filed: May 30, 2007
    Publication date: October 4, 2007
    Applicant: Acambis Inc.
    Inventors: William Thomas, Paul Giannasca, Zhenxi Zhang, Wende Lei, Thomas Monath
  • Patent number: 7115270
    Abstract: The invention provides attenuated vaccinia virus vaccines that can be used in methods to prevent or treat small pox in patients, as well as methods of obtaining such vaccines.
    Type: Grant
    Filed: May 27, 2003
    Date of Patent: October 3, 2006
    Assignee: Acambis Inc.
    Inventors: Richard A. Weltzin, Thomas P. Monath
  • Patent number: 6969520
    Abstract: The invention provides active and passive immunization methods for preventing and treating Clostridium difficile infection, which involve percutaneous administration of C. difficile toxin-neutralizing polyclonal immune globulin, C. difficile toxoids, or combinations thereof. Also provided by the invention are C. difficile toxoids, C. difficile toxin-neutralizing polyclonal immune globulin, and methods of identifying subjects that produce C. difficile toxin-neutralizing polyclonal immune globulin.
    Type: Grant
    Filed: December 16, 2003
    Date of Patent: November 29, 2005
    Assignee: Acambis Inc.
    Inventors: William D. Thomas, Jr., Paul J. Giannasca, Zhenxi Zhang, Wende Lei, Thomas P. Monath
  • Patent number: 6962708
    Abstract: A chimeric live, infectious, attenuated virus containing a yellow fever virus, in which the nucleotide sequence for a prM-E protein is either deleted, truncated, or mutated, so that functional prM-E protein is not expressed, and integrated into the genome of the yellow fever virus, a nucleotide sequence encoding a prM-E protein of a second, different flavivirus, so that the prM-E protein of the second flavivirus is expressed.
    Type: Grant
    Filed: July 23, 1998
    Date of Patent: November 8, 2005
    Assignees: Acambis, Inc., St. Louis University
    Inventors: Thomas J. Chambers, Thomas P. Monath, Farshad Guirakhoo, Juan Arroyo
  • Patent number: 6878372
    Abstract: The invention provides methods of preventing and treating flavivirus infection in animals.
    Type: Grant
    Filed: October 21, 2002
    Date of Patent: April 12, 2005
    Assignee: Acambis Inc.
    Inventors: Thomas P. Monath, Juan Arroyo
  • Patent number: 6723325
    Abstract: The invention provides attenuated vaccinia virus vaccines that can be used in methods to prevent or treat small pox in patients, as well as methods of obtaining such vaccines.
    Type: Grant
    Filed: April 23, 2001
    Date of Patent: April 20, 2004
    Assignee: Acambis, Inc.
    Inventors: Richard A. Weltzin, Thomas P. Monath
  • Patent number: 6696281
    Abstract: A chimeric live, infectious, attenuated virus containing a yellow fever virus, in which the nucleotide sequence for a prM-E protein is either deleted, truncated, or mutated, so that functional prM-E protein is not expressed, and integrated into the genome of the yellow fever virus, a nucleotide sequence encoding a prM-E protein of a second, different flavivirus, so that the prM-E protein of the second flavivirus is expressed.
    Type: Grant
    Filed: December 1, 1999
    Date of Patent: February 24, 2004
    Assignees: Acambis, Inc., St. Louis University
    Inventors: Thomas J. Chambers, Thomas P. Monath, Farshad Guirakhoo
  • Patent number: 6682883
    Abstract: The invention provides methods and kits for use in diagnosing flavivirus infection.
    Type: Grant
    Filed: July 19, 2001
    Date of Patent: January 27, 2004
    Assignee: Acambis, Inc.
    Inventors: Thomas P. Monath, Richard D. Nichols, Jr.
  • Patent number: 6680168
    Abstract: The invention provides active and passive immunization methods for preventing and treating Clostridium difficile infection, which involve percutaneous administration of C. difficile toxin-neutralizing polyclonal immune globulin, C. difficile toxoids, or combinations thereof. Also provided by the invention are C. difficile toxoids, C. difficile toxin-neutralizing polyclonal immune globulin, and methods of identifying subjects that produce C. difficile toxin-neutralizing polyclonal immune globulin.
    Type: Grant
    Filed: March 22, 2001
    Date of Patent: January 20, 2004
    Assignee: Acambis, Inc.
    Inventors: William D. Thomas, Jr., Paul J. Giannasca, Zhenxi Zhang, Wende Lei, Thomas P. Monath
  • Patent number: 6585975
    Abstract: The invention provides a method of immunization against Helicobacter, involving mucosal administration of an attenuated Salmonella vector including a nucleic acid molecule encoding a Helicobacter antigen, and parenteral administration of a soluble Helicobacter antigen, co-administered with a suitable parenteral adjuvant. Also provided by the invention are attenuated Salmonella vectors for use in this method.
    Type: Grant
    Filed: November 1, 1999
    Date of Patent: July 1, 2003
    Assignee: Acambis, Inc.
    Inventors: Harold Kleanthous, Patricia Londono-Arcila, Donna Freeman, Cynthia K. Lee, Thomas P. Monath
  • Patent number: 6576244
    Abstract: This invention provides methods of inducing a protective or therapeutic immune response to Helicobacter infection in a mammal by parenterally administering to the mammal one or more Helicobacter antigens and an adjuvant selected from one or more of LT, CT, LTB, and CTB.
    Type: Grant
    Filed: June 18, 1999
    Date of Patent: June 10, 2003
    Assignee: Acambis, Inc.
    Inventors: Richard A. Weltzin, Bruno Guy