Patents Assigned to AccuRna, Inc.
  • Composition for mRNA delivery
    Patent number: 10232054
    Abstract: A polyion complex of mRNA and a polycationic polymer, and a composition and a pharmaceutical composition for mRNA delivery are provided. The polyion complex of mRNA and the polycationic polymer can deliver mRNA into cells in the body of a subject almost without inducing inflammation. The polyion complex can then cause mRNA to be uniformly expressed in cells in the body of the subject. The pharmaceutical composition containing the polyion complex is suitable for use in treating a disease whose condition rapidly progresses or an acute disease.
    Type: Grant
    Filed: February 12, 2014
    Date of Patent: March 19, 2019
    Assignee: AccuRna, Inc.
    Inventors: Kazunori Kataoka, Keiji Itaka, Takehiko Ishii, Hirokuni Uchida, Satoshi Uchida, Miyuki Baba
  • POLYION COMPLEX CAPABLE OF EFFICIENTLY DELIVERING MRNA INTO LIVING BODY, AND DRUG AND METHOD FOR TREATING ARTHROPATHY IN WHICH SAID COMPLEX IS USED
    Publication number: 20190008980
    Abstract: The present invention provides a polyion complex which can efficiently deliver mRNA into a living body as well as a therapeutic agent and a therapeutic method of arthropathy in which the polyion complex is used. For example, there is provided a polyion complex comprising a cationic polymer and mRNA, wherein the cationic polymer is a polymer comprising a cationic unnatural amino acid as a monomer unit and the cationic unnatural amino acid is an amino acid having a group represented by —(NH—(CH2)2)p—NH2, wherein p is 2, 3 or 4, as a side chain.
    Type: Application
    Filed: July 29, 2016
    Publication date: January 10, 2019
    Applicant: AccuRna, Inc.
    Inventors: Keiji ITAKA, Shinsuke OHBA, Yuichi TEI, Kazunori KATAOKA
  • METHOD FOR IMPROVING PROTEIN EXPRESSION, AND COMPOSITION FOR PROTEIN EXPRESSION
    Publication number: 20170183389
    Abstract: The present invention provides a method for improving protein expression and a composition for protein expression. The composition is a composition for use in expressing a target protein, the composition comprising an mRNA encoding the target protein, wherein 80% or more of the mRNA molecules contained in the composition have a sequence consisting substantially of poly(A) having a length of 230 to 250 nucleotides on the 3?-end side of the protein-coding region thereof.
    Type: Application
    Filed: April 23, 2015
    Publication date: June 29, 2017
    Applicant: ACCURNA, INC.
    Inventors: Keiji ITAKA, Kazunori KATAOKA, Masaru IKEGAMI, Satoshi UCHIDA, Hirokuni UCHIDA, Kazuya NAGATA
  • COMPOSITION FOR mRNA DELIVERY
    Publication number: 20170173182
    Abstract: A polyion complex of mRNA and a polycationic polymer, and a composition and a pharmaceutical composition for mRNA delivery are provided. The polyion complex of mRNA and the polycationic polymer can deliver mRNA into cells in the body of a subject almost without inducing inflammation. The polyion complex can then cause mRNA to be uniformly expressed in cells in the body of the subject. The pharmaceutical composition containing the polyion complex is suitable for use in treating a disease whose condition rapidly progresses or an acute disease.
    Type: Application
    Filed: February 12, 2014
    Publication date: June 22, 2017
    Applicant: AccuRna, Inc.
    Inventors: Kazunori KATAOKA, Keiji ITAKA, Takehiko ISHII, Hirokuni UCHIDA, Satoshi UCHIDA, Miyuki BABA