Abstract: There is provided a collimator apparatus including a first collimator configured to prevent a leakage of radiation, wherein a target for converting electron beam emitted from an electron beam source into the radiation is disposed in the first collimator, and a second collimator, wherein the radiation passes through the second collimator along a central axis of the second collimator, the second collimator being disposed in an inner space formed in the first collimator, a gap between a surface of the inner space and the second collimator being provided, wherein the second collimator swings within the inner space of the first collimator.

Abstract: A radiation emitting apparatus includes a radiation source to generate radiation, a first collimator to define a maximum radiation field of the radiation; a second collimator to regulate the radiation field and direction of irradiation; a swing portion that swings in two directions orthogonal to each other; a displacement detector to detect displacement of the second collimator relative to a reference point; a drive mechanism to drive the swing portion; a control unit to control the drive mechanism; and a storage unit included in the control unit to store one or more parameters related to mechanical movement of the swing portion. The control unit generates feedforward control information based on an inputted target swing angle, a detected displacement, and the one or more parameters stored in the storage unit, and outputs a drive signal containing the feedforward control information to the drive mechanism.

Abstract: A phantom for simulating motions of both the body surface and the internal organs simultaneously, having a structure comprising of a body cell 12 and an internal organ part cell 2. The body cell 12 simulates a body. The internal organ part cell 2 is installed inside a body cell 12 and contains internal organ cells 11a and 11b which simulate internal organs like lung and others. Each of the body cell 12, the internal organ part cell 2 and the internal organ cells 11a and 11b has elastic surface and is able to expand like a balloon. Each cell is provided with a protrusion 170 for connecting a tube 40 to pass fluid.

Abstract: A radiation therapy apparatus includes a manipulator; a radiation head; a correction unit; and first and second controllers. The manipulator includes an arm movable about n axes (where n is 6 or more). The radiation head, supported by the arm, is configured to emit radiation. The correction unit continuously corrects positional coordinates of the radiation head on the manipulator so that radiation emitted from the radiation head is directed onto a reference point while the radiation head is moved along a predetermined route on a virtual sphere having the reference point as its center. The first controller controls the manipulator so that the radiation head is moved along the route using the corrected positional coordinates. The second controller causes the radiation head to emit radiation toward the reference point as the radiation head passes through radiation emission points on the route.

Abstract: A radiation emitting apparatus includes a radiation source to generate radiation, a first collimator to define a maximum radiation field of the radiation; a second collimator to regulate the radiation field and direction of irradiation; a swing portion that swings in two directions orthogonal to each other; a displacement detector to detect displacement of the second collimator relative to a reference point; a drive mechanism to drive the swing portion; a control unit to control the drive mechanism; and a storage unit included in the control unit to store one or more parameters related to mechanical movement of the swing portion. The control unit generates feedforward control information based on an inputted target swing angle, a detected displacement, and the one or more parameters stored in the storage unit, and outputs a drive signal containing the feedforward control information to the drive mechanism.

Abstract: There is provided a collimator apparatus including a first collimator configured to prevent a leakage of radiation, wherein a target for converting electron beam emitted from an electron beam source into the radiation is disposed in the first collimator, and a second collimator, wherein the radiation passes through the second collimator along a central axis of the second collimator, the second collimator being disposed in an inner space formed in the first collimator, a gap between a surface of the inner space and the second collimator being provided, wherein the second collimator swings within the inner space of the first collimator.

Abstract: A radiation therapy apparatus including a robot supporting a robot head; a therapeutic radiation source attached to the robot head; a collimator for adjusting a radiation field shape of therapeutic radiation radiated from the therapeutic radiation source; a first therapeutic radiation detector attached to the robot head; a couch configured to support a patient lying supine thereon; a second therapeutic radiation detector for detecting the therapeutic radiation, disposed opposite the first therapeutic radiation detector with the couch disposed therebetween; at least two X-ray sources and detectors for position detection of a marker and/or a treatment target; an image processor for reconstructing an image of the treatment target; and a CPU that computes the intensity, irradiation direction, dose, and dose distribution of the therapeutic radiation, and dose absorbed by the treatment target, radiation field shape, and position of the treatment target in real time for feedback to a next irradiation.

Abstract: An X-ray collimator for controlling an X-ray radiation field, having a lower base member, a pair of regulating members, a pair of surrounding members having substantially U-shaped forms in planar view, N columnar members surrounded by the pair of surrounding members (where N is 4, 6, or 8), a guiding member, a pair of moving members moving parallel to the opposed surfaces of the regulating members, an upper base member, a first motor for horizontally moving the pair of moving members, and a second motor for moving the columnar members. The first motor is driven to horizontally move the pair of moving members over the same distance in opposite directions. The second motor is configured to move one of the columnar members along an internal surface of the surrounding member surrounding the columnar member, thereby moving the other N?1 columnar members sequentially.

Abstract: A radiation therapy apparatus including a robot supporting a robot head; a therapeutic radiation source attached to the robot head; a collimator for adjusting a radiation field shape of therapeutic radiation radiated from the therapeutic radiation source; a first therapeutic radiation detector attached to the robot head; a couch configured to support a patient lying supine thereon; a second therapeutic radiation detector for detecting the therapeutic radiation, disposed opposite the first therapeutic radiation detector with the couch disposed therebetween; at least two X-ray sources and detectors for position detection of a marker and/or a treatment target; an image processor for reconstructing an image of the treatment target; and a CPU that computes the intensity, irradiation direction, dose, and dose distribution of the therapeutic radiation, and dose absorbed by the treatment target, radiation field shape, and position of the treatment target in real time for feedback to a next irradiation.

Abstract: An X-ray collimator for controlling an X-ray radiation field, having a lower base member, a pair of regulating members, a pair of surrounding members having substantially U-shaped forms in planar view, N columnar members surrounded by the pair of surrounding members (where N is 4, 6, or 8), a guiding member, a pair of moving members moving parallel to the opposed surfaces of the regulating members, an upper base member, a first motor for horizontally moving the pair of moving members, and a second motor for moving the columnar members. The first motor is driven to horizontally move the pair of moving members over the same distance in opposite directions. The second motor is configured to move one of the columnar members along an internal surface of the surrounding member surrounding the columnar member, thereby moving the other N?1 columnar members sequentially.

Abstract: An X-ray treatment apparatus comprises a low energy X-ray generator for detecting a marker, a marker sensor detecting a position of the marker fixed in the patient to a couch, and both low energy X-ray generator and the marker sensor are installed in the couch, a high energy X-ray generator for treatment, a X-ray sensor for treatment detecting the high energy X-ray for treatment. An X-ray treatment method using the X-ray treatment apparatus comprises the steps of detecting a position of a marker by the marker sensor, irradiating to a lesion the high energy X-ray for treatment, detecting the penetrated high energy X-ray for treatment by the X-ray sensor for treatment, modifying the beam profile, the dosage or/and the radiation direction of the X-ray for treatment according to the latest data of the sensors, performing the next radiation for the lesion.

Abstract: An X-ray treatment apparatus comprises a low energy X-ray generator for detecting a marker, a marker sensor detecting a position of the marker fixed in the patient to a couch, and both low energy X-ray generator and the marker sensor are installed in the couch, a high energy X-ray generator for treatment, a X-ray sensor for treatment detecting the high energy X-ray for treatment. An X-ray treatment method using the X-ray treatment apparatus comprises the steps of detecting a position of a marker by the marker sensor, irradiating to a lesion the high energy X-ray for treatment, detecting the penetrated high energy X-ray for treatment by the X-ray sensor for treatment, modifying the beam profile, the dosage or/and the radiation direction of the X-ray for treatment according to the latest data of the sensors, performing the next radiation for the lesion.

Abstract: The present invention provides compounds of formula (I): where X is R1—(CR3R4)nOC(O)—; R1—(CR3R4)nC(O)—; R1—C(O)NH(CR3R4)nOC(O)—; R1—C(O)NH(CR3R4)nC(O)—; R1—C(O)(CR3R4)nOC(O)—; or R1—C(O)(CR3R4)nC(O)—; where R1 is optionally substituted C5-10 aryl or heteroaryl; OH or NH2; where R3 and R4 are independently H or methyl; and n is 0 to 6; and Y is —CF3 or one of: where R2 is C1-8 alkyl optionally substituted with halo or —OH; —(CR6R7)p—C5-6 aryl optionally substituted with halo, —OH, C1-8 alkyl, C1-8 haloalkyl, —(CH2)mC(O)NH2 or —(CH2)mOCH3; where R6 and R7 are independently H or methyl; m is 0 to 4, and p is 0 or 1 or a pharmaceutically acceptable salt, ester, metabolite or prodrug thereof