Abstract: The present invention relates to surface-located polypeptides of Campylobacter jejuni and their use in vaccination against Campylobacter. The invention furthermore relates to the use in vaccination of polynucleotides, expression vectors, recombinant viruses or recombinant cells expressing these surface-located polypeptides. Moreover, the invention relates to the use of antibodies against the surface-located polypeptides for anti-Campylobacter therapy. Finally, methods for detection of Campylobacter and for identifying anti-Campylobacter agents through the surface-located polypeptides is disclosed.
Type:
Application
Filed:
November 19, 2004
Publication date:
August 2, 2007
Applicant:
ACE BioSciences A/S
Inventors:
Petra Schrotz-King, Janne Skaarup Crawford, Pia Nyborg Nielsen, Tatyana Prokhorova
Abstract: The present invention relates to extracellular polypeptides of Aspergillus fumigatus, to fragments of these polypeptides, to compositions comprising such polypeptides and fragments and to exposed domains and epitopes of these polypeptides. The invention also relates to the use of these polypeptides and fragments for immunisation and for production of antibodies, and to antibodies that recognise and bind the polypeptides. Furthermore, the invention relates to methods of identifying binding partners and inhibitors, and to methods of preventing, treating and diagnosing Aspergillus infections.
Type:
Application
Filed:
June 10, 2004
Publication date:
October 26, 2006
Applicant:
ACE BioSciences A/S
Inventors:
Andrew Roche, Martin Hansen, Inge Villsen, Petra Schrotz-King, Jeannette Henningsen, Trine Jørgensen