Abstract: A method for changing at least one biological property of a biological tissue, the method having the steps of providing a biological tissue having at least a first layer; evaluating the topography, biomechanical and fundamental properties of the biological tissue by layer; and orienting a matrix complex in the biological tissue, wherein the matrix complex has matrices that are balanced in a mathematical relationship, wherein each of the matrices comprises a perforation formation in the tissue, and wherein the mathematical relationship comprises a mathematical algorithm.