Patents Assigned to Acedemisch Ziekenhuis Leiden h.o.d.n. LUMC
  • MOLECULE FOR TREATING AN INFLAMMATORY DISORDER
    Publication number: 20120259002
    Abstract: The invention provides two types of oligonucleotides for treating an inflammatory disorder: an oligonucleotide which is able of altering the splicing of a pre-mRNA encoding a C5 in order to decrease the amount of a C5a and an oligonucleotide which is able of altering the splicing of a pre-mRNA encoding a IL-1RAcP in order to increase the amount of a soluble IL-1RAcP. The invention further provides the use of said oligonucleotides for preventing or treating an inflammatory disorder.
    Type: Application
    Filed: June 21, 2012
    Publication date: October 11, 2012
    Applicants: Acedemisch Ziekenhuis Leiden h.o.d.n. LUMC, Prosensa Technologies B.V.
    Inventors: Garrit-Jan Boudewijn Van Ommen, Annemieke Aartsma-Rus, Judith Christina Theodora Van Deutekom, Josephus Johannes De Kimpe, Joseph Stephan Verbeek, Aliye Seda Ylmaz-Elis