Patents Assigned to Acelot, Inc.
  • Patent number: 12312296
    Abstract: Described herein, inter alia, are certain substituted piperazines, for example, having the Formula 182, and pharmaceutical compositions for the treatment and prevention of diseases related to the formation of A?42 oligomers in a subject. It further provides a method of reducing formation of or disrupting A?42 oligomers in a subject, the method comprising the step of administering to the subject in need thereof a therapeutically effective amount of a pharmaceutical composition.
    Type: Grant
    Filed: February 2, 2023
    Date of Patent: May 27, 2025
    Assignee: ACELOT, INC.
    Inventors: Ambuj K. Singh, Christian A. Lang
  • Patent number: 11827582
    Abstract: The present disclosure provides small molecule drugs and pharmaceutical compositions for the treatment and prevention of diseases related to the formation of A?42 oligomers in a subject. It further provides a method of reducing formation of or disrupting A?42 oligomers in a subject, the method comprising the step of administering to the subject in need thereof a therapeutically effective amount of a pharmaceutical composition.
    Type: Grant
    Filed: March 31, 2020
    Date of Patent: November 28, 2023
    Assignee: ACELOT, INC.
    Inventors: Ambuj K. Singh, Christian A. Lang
  • Publication number: 20230331658
    Abstract: The present invention provides small molecule drugs and pharmaceutical compositions for the treatment and prevention of diseases related to the formation of A?42 oligomers in a subject. It further provides a method of reducing formation of or disrupting A?42 oligomers in a subject, the method comprising the step of administering to the subject in need thereof a therapeutically effective amount of a pharmaceutical composition.
    Type: Application
    Filed: February 2, 2023
    Publication date: October 19, 2023
    Applicant: ACELOT, INC.
    Inventors: Ambuj K. Singh, Christian A. Lang
  • Publication number: 20210052519
    Abstract: The present invention provides small molecule drugs and pharmaceutical compositions for the treatment and prevention of diseases related to the formation of certain types of oligomers in a subject. More specifically, the drugs and compositions reduce or prevent the formation of oligomers formed from tau protein, TDP-43, Huntingtin's protein and/or alpha-synuclein. It further provides a method of reducing formation of or disrupting TDP-43, alpha-synuclein, Huntingtin's protein and/or tau protein oligomers in a subject, the method comprising the step of administering to the subject in need thereof a therapeutically effective amount of a pharmaceutical composition.
    Type: Application
    Filed: July 31, 2020
    Publication date: February 25, 2021
    Applicant: ACELOT,INC
    Inventors: Ambuj K. SINGH, Christian A. LANG
  • Patent number: 10703711
    Abstract: The present invention provides small molecule drugs and pharmaceutical compositions for the treatment and prevention of diseases related to the formation of A?42 oligomers in a subject. It further provides a method of reducing formation of or disrupting A?42 oligomers in a subject, the method comprising the step of administering to the subject in need thereof a therapeutically effective amount of a pharmaceutical composition.
    Type: Grant
    Filed: November 5, 2018
    Date of Patent: July 7, 2020
    Assignee: Acelot, Inc.
    Inventors: Ambuj K. Singh, Christian A. Lang