Patents Assigned to Acetylon Pharmaceuticals
  • Reverse amide compounds as protein deacetylase inhibitors and methods of use thereof
    Patent number: 8609678
    Abstract: The present invention relates to “reverse amide” compounds comprising a zinc chelator group, and the use of such compounds in the inhibition of HDAC6 and in the treatment of various diseases, disorders or conditions related to HDAC6.
    Type: Grant
    Filed: April 2, 2012
    Date of Patent: December 17, 2013
    Assignee: Acetylon Pharmaceuticals
    Inventors: John H. Van Duzer, Ralph Mazitschek, Walter Ogier, James E. Bradner, Guoxiang Huang, Dejian Xie, Nan Yu
  • SPECIFIC REGULATION OF CYTOKINE LEVELS BY HDAC6 INHIBITORS
    Publication number: 20130225543
    Abstract: The invention provides for methods of treating a disease using HDAC6 inhibitors that modulate the extracellular level of a subset of cytokines. The invention also provides for compositions for treating a disease associated with a modulation in the extracellular level of a subset of cytokines.
    Type: Application
    Filed: February 5, 2013
    Publication date: August 29, 2013
    Applicant: Acetylon Pharmaceuticals
    Inventors: Simon S. Jones, Matthew Blair Jarpe
  • Reverse amide compounds as protein deacetylase inhibitors and methods of use thereof
    Patent number: 8394810
    Abstract: The present invention relates to novel “reverse amide” compounds comprising a zinc chelator group, and the use of such compounds in the inhibition of HDAC6 and in the treatment of various diseases, disorders or conditions related to HDAC6.
    Type: Grant
    Filed: January 21, 2011
    Date of Patent: March 12, 2013
    Assignee: Acetylon Pharmaceuticals
    Inventors: John H. van Duzer, Ralph Mazitschek, Walter Ogier, James E. Bradner, Guoxiang Huang, Dejian Xie, Nan Yu
  • PYRIMIDINE HYDROXY AMIDE COMPOUNDS AS PROTEIN DEACETYLASE INHIBITORS AND METHODS OF USE THEREOF
    Publication number: 20120121502
    Abstract: The present invention relates to novel pyrimidine hydroxy amide compounds, and the use of such compounds in the inhibition of HDAC6 and in the treatment of various diseases, disorders or conditions related to HDAC6.
    Type: Application
    Filed: November 15, 2011
    Publication date: May 17, 2012
    Applicant: ACETYLON PHARMACEUTICALS
    Inventors: John H. van Duzer, Ralph Mazitschek, Yanbing Ding, Nan Yu, Yun Cao, Yong Liu
  • Reverse amide compounds as protein deacetylase inhibitors and methods of use thereof
    Patent number: 8148526
    Abstract: The present invention relates to novel “reverse amide” compounds comprising a zinc chelator group, and the use of such compounds in the inhibition of HDAC6 and in the treatment of various diseases, disorders or conditions related to HDAC6.
    Type: Grant
    Filed: December 2, 2011
    Date of Patent: April 3, 2012
    Assignee: Acetylon Pharmaceuticals
    Inventors: John H. van Duzer, Ralph Mazitschek, Walter Ogier, James E. Bradner, Guoxiang Huang, Dejian Xie, Nan Yu
  • REVERSE AMIDE COMPOUNDS AS PROTEIN DEACETYLASE INHIBITORS AND METHODS OF USE THEREOF
    Publication number: 20110300134
    Abstract: The present invention relates to novel “reverse amide” compounds comprising a zinc chelator group, and the use of such compounds in the inhibition of HDAC6 and in the treatment of various diseases, disorders or conditions related to HDAC6.
    Type: Application
    Filed: January 21, 2011
    Publication date: December 8, 2011
    Applicant: ACETYLON PHARMACEUTICALS
    Inventors: John H. van Duzer, Ralph Mazitschek, Walter Ogier, James E. Bradner, Guoxiang Huang, Dejian Xie, Nan Yu