Abstract: Provided herein are methods for converting CBD to a product mixture comprising ?8-THC, ?9-THC, or a combination thereof. The methods provided herein may comprise one or more of (1) a contacting step wherein a starting material comprising CBD, a catalyst comprising a zeolite, and optionally a solvent are added to a reaction vessel, thereby forming a reaction mixture; (2) a conversion step wherein at least a portion of the CBD is converted to THC, thereby forming a product mixture; and (3) optionally, a separation step wherein at least a portion of the catalyst is removed from the product mixture. Advantageously, the methods do not require the use of catalysts or other reagents that are hazardous to human health.

Abstract: Provided herein are methods for converting CBD to a product mixture comprising ?8-THC, ?9-THC, or a combination thereof. The methods provided herein may comprise one or more of (1) a contacting step wherein a starting material comprising CBD, a carboxylic acid catalyst, and optionally a solvent are added to a reaction vessel, thereby forming a reaction mixture; (2) a conversion step wherein at least a portion of the CBD is converted to THC, thereby forming a product mixture; and (3) optionally, a separation step wherein at least a portion of the carboxylic acid catalyst is removed from the product mixture. In preferred embodiments, the methods utilize a carboxylic acid that is commonly used as a food additive and is generally recognized as safe for human consumption. The methods provided herein do not require the use of catalysts or other reagents that are hazardous to human health.

Abstract: Provided herein are methods for converting CBD to a product mixture comprising ?8-THC, ?9-THC, or a combination thereof. The methods provided herein may comprise one or more of (1) a contacting step wherein a starting material comprising CBD, a catalyst comprising an iron (III) salt, and optionally a solvent are added to a reaction vessel, thereby forming a reaction mixture; (2) a conversion step wherein at least a portion of the CBD is converted to THC, thereby forming a product mixture; and (3) optionally, a separation step wherein at least a portion of the catalyst is removed from the product mixture. Advantageously, the methods utilize a catalyst comprising iron (III) sulfate, which is commonly used as a food additive and is generally recognized as safe for human consumption, and do not require the use of catalysts or other reagents that are hazardous to human health.