Abstract: The invention relates to (S)-acyl-4?-phosphopantetheine derivatives, methods of their synthesis, and related medical uses of such compounds. Preferred medical uses relate to the treatment of neurodegenerative diseases, such as PKAN.
Type:
Grant
Filed:
October 29, 2014
Date of Patent:
May 8, 2018
Assignees:
ACIES BIO D.O.O., RIJKSUNIVERSITEIT GRONINGEN, ACADEMISCH ZIEKENHUIS GRONINGEN
Inventors:
Branko Jenko, Gregor Kosec, Hrvoje Petkovic, Ajda Podgorsek Berke, Jerca Pahor, Alen Cusak, Oda Cornelia Maria Sibon, Balaji Srinivasan
Abstract: The invention provides a fungal cell, such as a yeast cell, capable of growing in co-cultivation with Propionibacterium. Also provided are methods of producing such cells and fermentation processes using the fungal cell of the invention and Propionibacterium in co-cultivation. Such co-cultivation significantly reduces the chemical oxygen demand load of the waste fermentation broth.
Type:
Grant
Filed:
May 8, 2015
Date of Patent:
April 10, 2018
Assignees:
Acies Bio d.o.o., Arima d.o.o
Inventors:
Mirjan Svagelj, Stefan Fujs, Gregor Kosec, Hrvoje Petkovic