Abstract: The present invention relates to compounds showing pharmacological activity towards the subunit ?2?#of voltage-gated calcium channels (VGCC), especially the ?2?-1 subunit of voltage-gated calcium channels. More particularly, the invention relates to alkylaminoproline derivatives having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain and/or as neuroprotective agents.

Abstract: The present invention relates to a procedure for finishing stainless steel parts. The finishing process of the invention is particularly useful for stainless steel parts of complex structure such as those produced by additive manufacturing of metals.

Abstract: The present invention relates to compounds showing pharmacological activity towards the subunit ?2? # of voltage-gated calcium channels (VGCC), especially the ?2?-1 subunit of voltage-gated calcium channels. More particularly, the invention relates to alkylaminoproline derivatives having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain and/or as neuroprotective agents.

Abstract: The present invention relates to a method for polishing parts made of aluminum, and more specifically parts made of aluminum with a high content of silicon and produced by additive manufacturing.

Abstract: The present invention refers to a method for polishing polyamide objects obtained by additive manufacturing or 3D printing techniques, which comprises immersion of the polyamide object in a mixture of formic acid and dichloromethane at room temperature for a period of time comprised between 5 seconds and 6 minutes. This method allows effectively elimination or reduction of the roughness of the polyamide objects obtained by additive manufacturing or 3D printing techniques, for example, obtained by techniques such as the Selective Laser Sintering (SLS) with a simple procedure which does not require neither high temperatures nor extended treatment times. The present invention also refers to the object obtainable according to such method.

Abstract: A functionalized lithium anode for batteries, which is obtainable according to a specific process using diazonium salts. The embodiments also relate to the use of that lithium anode in cells, to a cell including that lithium anode, to the use of that cell in an electronic device, and to an electronic device including that cell.

Abstract: The present invention relates to piperazinyl and piperidinyl quinazolin-4(3H)-one derivatives having pharmacological activity towards the ?2? subunit, in particular the ?2?-1 subunit, of the voltage-gated calcium channel, in particular having dual pharmacological activity towards both the ?2? subunit, in particular the ?2?-1 subunit, of the voltage-gated calcium channel and the ?-opioid receptor. The present invention also relates to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.

Abstract: Liquid treatment filter with magnetite nanoparticles and corresponding methods. Liquid treatment filter comprising a support made of a polymeric material having at least one functional group of the group made up of carboxyl and thiol, loaded with SPION (SuperParamagnetic Iron Oxide Nanoparticles). The support is advantageously made of fibres of hydrolysed polyacrylonitrile of general formula wherein n has a value comprised between 0.01 and 1, and wherein the method for manufacturing comprises: [a] a step of electrospinning in which a solution of polyacrylonitrile is prepared in a solvent with a polyacrylonitrile content comprised between 5 and 80% by weight, with respect to the total weight of the solution, [b] a step of hydrolysis of the PAN fibres formed in step [a], and [c] a step of loading the fibres with SPION.